Entry Database : PDB / ID : 6e7i Structure visualization Downloads & linksTitle Human ppGalNAcT2 I253A/L310A Mutant with EA2 and UDP ComponentsEA2 Polypeptide N-acetylgalactosaminyltransferase 2 DetailsKeywords TRANSFERASE / glycosyltransferase / glycosylation / bump-hole / galnacFunction / homology Function and homology informationFunction Domain/homology Component
protein O-linked glycosylation via threonine / protein O-linked glycosylation via serine / polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / protein O-linked GalNAcylation / O-linked glycosylation of mucins / regulation of sensory perception of pain / peptidase inhibitor activity / Golgi stack / protein O-linked glycosylation ... protein O-linked glycosylation via threonine / protein O-linked glycosylation via serine / polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / protein O-linked GalNAcylation / O-linked glycosylation of mucins / regulation of sensory perception of pain / peptidase inhibitor activity / Golgi stack / protein O-linked glycosylation / COPI-independent Golgi-to-ER retrograde traffic / Golgi cisterna membrane / endopeptidase inhibitor activity / positive regulation of immunoglobulin production / protein maturation / manganese ion binding / carbohydrate binding / Golgi membrane / endoplasmic reticulum membrane / perinuclear region of cytoplasm / Golgi apparatus / extracellular region / membrane Similarity search - Function N-acetylgalactosaminyltransferase / Glycosyltransferase 2-like / Glycosyl transferase family 2 / Ricin-type beta-trefoil lectin domain / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A ... N-acetylgalactosaminyltransferase / Glycosyltransferase 2-like / Glycosyl transferase family 2 / Ricin-type beta-trefoil lectin domain / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A / Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A / Nucleotide-diphospho-sugar transferases / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.8 Å DetailsAuthors Bertozzi, C.R. / Schumann, B. / Agbay, A.J. Funding support United States, 1items Details Hide detailsOrganization Grant number Country Howard Hughes Medical Institute (HHMI) NIH R01 CA200423 United States
CitationJournal : Mol.Cell / Year : 2020Title : Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells.Authors: Schumann, B. / Malaker, S.A. / Wisnovsky, S.P. / Debets, M.F. / Agbay, A.J. / Fernandez, D. / Wagner, L.J.S. / Lin, L. / Li, Z. / Choi, J. / Fox, D.M. / Peh, J. / Gray, M.A. / Pedram, K. / ... Authors : Schumann, B. / Malaker, S.A. / Wisnovsky, S.P. / Debets, M.F. / Agbay, A.J. / Fernandez, D. / Wagner, L.J.S. / Lin, L. / Li, Z. / Choi, J. / Fox, D.M. / Peh, J. / Gray, M.A. / Pedram, K. / Kohler, J.J. / Mrksich, M. / Bertozzi, C.R. History Deposition Jul 26, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 29, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Sep 23, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Oct 11, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 1.3 Oct 16, 2024 Group : Structure summary / Category : pdbx_entry_details / pdbx_modification_feature
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