+Open data
-Basic information
Entry | Database: PDB / ID: 6dwn | ||||||
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Title | Structure of Human Cytochrome P450 1A1 with Erlotinib | ||||||
Components | Cytochrome P450 1A1 | ||||||
Keywords | OXIDOREDUCTASE / ligand | ||||||
Function / homology | Function and homology information arachidonate monooxygenase activity / ethylene metabolic process / flavonoid 3'-monooxygenase activity / insecticide metabolic process / dibenzo-p-dioxin catabolic process / long-chain fatty acid omega-hydroxylase activity / oxidoreductase activity, acting on diphenols and related substances as donors / long-chain fatty acid omega-1 hydroxylase activity / 9-cis-retinoic acid biosynthetic process / hydroperoxy icosatetraenoate dehydratase ...arachidonate monooxygenase activity / ethylene metabolic process / flavonoid 3'-monooxygenase activity / insecticide metabolic process / dibenzo-p-dioxin catabolic process / long-chain fatty acid omega-hydroxylase activity / oxidoreductase activity, acting on diphenols and related substances as donors / long-chain fatty acid omega-1 hydroxylase activity / 9-cis-retinoic acid biosynthetic process / hydroperoxy icosatetraenoate dehydratase / hydroperoxy icosatetraenoate dehydratase activity / Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) / omega-hydroxylase P450 pathway / coumarin metabolic process / response to 3-methylcholanthrene / maternal process involved in parturition / flavonoid metabolic process / porphyrin-containing compound metabolic process / response to iron(III) ion / long-chain fatty acid metabolic process / Biosynthesis of protectins / epoxygenase P450 pathway / tissue remodeling / response to nematode / vitamin D 24-hydroxylase activity / estrogen 16-alpha-hydroxylase activity / estrogen 2-hydroxylase activity / lipid hydroxylation / demethylase activity / vitamin D metabolic process / Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) / hepatocyte differentiation / steroid biosynthetic process / Xenobiotics / amine metabolic process / response to arsenic-containing substance / camera-type eye development / digestive tract development / response to vitamin A / long-chain fatty acid biosynthetic process / hydrogen peroxide biosynthetic process / response to herbicide / estrogen metabolic process / retinol metabolic process / response to food / unspecific monooxygenase / aromatase activity / nitric oxide metabolic process / positive regulation of G1/S transition of mitotic cell cycle / steroid metabolic process / cellular response to organic cyclic compound / response to immobilization stress / response to hyperoxia / fatty acid metabolic process / cellular response to copper ion / Hsp70 protein binding / monooxygenase activity / xenobiotic metabolic process / PPARA activates gene expression / Hsp90 protein binding / oxygen binding / response to lipopolysaccharide / oxidoreductase activity / response to hypoxia / mitochondrial inner membrane / iron ion binding / intracellular membrane-bounded organelle / endoplasmic reticulum membrane / heme binding / enzyme binding Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3 Å | ||||||
Authors | Bart, A.G. / Scott, E.E. | ||||||
Funding support | United States, 1items
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Citation | Journal: J. Biol. Chem. / Year: 2018 Title: Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands. Authors: Bart, A.G. / Scott, E.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6dwn.cif.gz | 871.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6dwn.ent.gz | 593 KB | Display | PDB format |
PDBx/mmJSON format | 6dwn.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6dwn_validation.pdf.gz | 3 MB | Display | wwPDB validaton report |
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Full document | 6dwn_full_validation.pdf.gz | 3 MB | Display | |
Data in XML | 6dwn_validation.xml.gz | 65.3 KB | Display | |
Data in CIF | 6dwn_validation.cif.gz | 84.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/dw/6dwn ftp://data.pdbj.org/pub/pdb/validation_reports/dw/6dwn | HTTPS FTP |
-Related structure data
Related structure data | 6dwmC 4i8vS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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