Entry | Database: PDB / ID: 6cht |
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Title | HNF4alpha in complex with the corepressor EBP1 fragment |
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Components | - Hepatocyte nuclear factor 4-alpha
- Proliferation-associated protein 2G4
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Keywords | TRANSCRIPTION / HNF4alpha / EBP1 / nuclear receptor / co-repressor / protein-protein interaction / gene regulation / insulin secretion / diabetes |
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Function / homology | Function and homology information
regulation of growth hormone receptor signaling pathway / ornithine metabolic process / regulation of gastrulation / Nephron development / sex differentiation / phospholipid homeostasis / signal transduction involved in regulation of gene expression / lipid homeostasis / triglyceride homeostasis / Regulation of gene expression in beta cells ...regulation of growth hormone receptor signaling pathway / ornithine metabolic process / regulation of gastrulation / Nephron development / sex differentiation / phospholipid homeostasis / signal transduction involved in regulation of gene expression / lipid homeostasis / triglyceride homeostasis / Regulation of gene expression in beta cells / regulation of insulin secretion / regulation of lipid metabolic process / response to glucose / xenobiotic metabolic process / cholesterol homeostasis / fatty acid binding / regulation of circadian rhythm / lipid metabolic process / positive regulation of cell differentiation / Nuclear Receptor transcription pathway / negative regulation of cell growth / nuclear receptor activity / rhythmic process / rRNA processing / transcription corepressor activity / azurophil granule lumen / blood coagulation / sequence-specific double-stranded DNA binding / glucose homeostasis / regulation of translation / DNA-binding transcription activator activity, RNA polymerase II-specific / nucleic acid binding / RNA polymerase II-specific DNA-binding transcription factor binding / transcription cis-regulatory region binding / transcription by RNA polymerase II / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / ribonucleoprotein complex / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / signaling receptor binding / negative regulation of DNA-templated transcription / chromatin binding / ubiquitin protein ligase binding / regulation of transcription by RNA polymerase II / Neutrophil degranulation / positive regulation of DNA-templated transcription / chromatin / negative regulation of apoptotic process / nucleolus / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / DNA binding / RNA binding / zinc ion binding / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / cytoplasmSimilarity search - Function : / : / PA2G4 family / : / Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site / Methionine aminopeptidase subfamily 2 signature. / : / Peptidase M24 / Metallopeptidase family M24 / Creatinase/aminopeptidase-like ...: / : / PA2G4 family / : / Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site / Methionine aminopeptidase subfamily 2 signature. / : / Peptidase M24 / Metallopeptidase family M24 / Creatinase/aminopeptidase-like / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Ligand-binding domain of nuclear hormone receptor / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.174 Å |
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Authors | Chi, Y.I. / Singh, P. / Lee, I.K. |
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Funding support | United States, 1items Organization | Grant number | Country |
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American Diabetes Association | 7-08-CD-03 | United States |
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Citation | Journal: J.Biol.Chem. / Year: 2019 Title: ErbB3-binding protein 1 (EBP1) represses HNF4 alpha-mediated transcription and insulin secretion in pancreatic beta-cells. Authors: Han, E.H. / Singh, P. / Lee, I.K. / Urrutia, R. / Chi, Y.I. |
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History | Deposition | Feb 22, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Feb 27, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 16, 2019 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Oct 4, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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