Entry | Database: PDB / ID: 6aex |
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Title | Crystal structure of unoccupied murine uPAR |
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Components | Urokinase plasminogen activator surface receptor |
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Keywords | CELL INVASION / uPAR / TFPDs |
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Function / homology | Function and homology information
Attachment of GPI anchor to uPAR / Dissolution of Fibrin Clot / positive regulation of homotypic cell-cell adhesion / mesenchymal cell differentiation / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / epithelial cell differentiation involved in prostate gland development / regulation of fibrinolysis / protein complex involved in cell-matrix adhesion / serine-type endopeptidase complex ...Attachment of GPI anchor to uPAR / Dissolution of Fibrin Clot / positive regulation of homotypic cell-cell adhesion / mesenchymal cell differentiation / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / epithelial cell differentiation involved in prostate gland development / regulation of fibrinolysis / protein complex involved in cell-matrix adhesion / serine-type endopeptidase complex / positive regulation of epidermal growth factor receptor signaling pathway / positive regulation of release of cytochrome c from mitochondria / regulation of cell adhesion / negative regulation of intrinsic apoptotic signaling pathway / Neutrophil degranulation / positive regulation of protein phosphorylation / protein domain specific binding / external side of plasma membrane / signaling receptor binding / negative regulation of apoptotic process / enzyme binding / cell surface / extracellular region / plasma membraneSimilarity search - Function CD59 antigen, conserved site / Ly-6 / u-PAR domain signature. / Ly-6 antigen / uPA receptor -like domain / u-PAR/Ly-6 domain / Ly-6 antigen/uPA receptor-like / Snake toxin-like superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.393 Å |
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Authors | Min, L. / Huang, M. |
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Funding support | China, 4items Organization | Grant number | Country |
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National Natural Science Foundation of China | 31370737 | China | National Natural Science Foundation of China | 31400637 | China | National Natural Science Foundation of China | 31570745 | China | National Natural Science Foundation of China | 31670739 | China |
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Citation | Journal: Febs Lett. / Year: 2019 Title: Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit. Authors: Liu, M. / Lin, L. / Hoyer-Hansen, G. / Ploug, M. / Li, H. / Jiang, L. / Yuan, C. / Li, J. / Huang, M. |
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History | Deposition | Aug 6, 2018 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Jul 17, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 29, 2020 | Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 1.2 | Nov 22, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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