登録情報 | データベース: PDB / ID: 5zoj |
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タイトル | Crystal structure of human SMAD2-MAN1 complex |
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要素 | - Inner nuclear membrane protein Man1
- Mothers against decapentaplegic homolog 2
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キーワード | DNA BINDING PROTEIN / Transcription / Complex / TGF-beta signaling |
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機能・相同性 | 機能・相同性情報
zygotic specification of dorsal/ventral axis / regulation of binding / homomeric SMAD protein complex / paraxial mesoderm morphogenesis / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / nodal signaling pathway / SMAD protein complex / endoderm formation ...zygotic specification of dorsal/ventral axis / regulation of binding / homomeric SMAD protein complex / paraxial mesoderm morphogenesis / activin responsive factor complex / SMAD4 MH2 Domain Mutants in Cancer / SMAD2/3 MH2 Domain Mutants in Cancer / nodal signaling pathway / SMAD protein complex / endoderm formation / heteromeric SMAD protein complex / co-SMAD binding / Depolymerization of the Nuclear Lamina / odontoblast differentiation / determination of left/right asymmetry in lateral mesoderm / secondary palate development / Nuclear Envelope Breakdown / nuclear envelope organization / pericardium development / FOXO-mediated transcription of cell cycle genes / regulation of transforming growth factor beta receptor signaling pathway / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / Transcriptional regulation of pluripotent stem cells / embryonic foregut morphogenesis / primary miRNA processing / transforming growth factor beta receptor binding / Germ layer formation at gastrulation / pulmonary valve morphogenesis / type I transforming growth factor beta receptor binding / Formation of definitive endoderm / signal transduction involved in regulation of gene expression / activin receptor signaling pathway / SMAD protein signal transduction / negative regulation of activin receptor signaling pathway / Signaling by Activin / Initiation of Nuclear Envelope (NE) Reformation / Formation of axial mesoderm / positive regulation of BMP signaling pathway / U1 snRNP binding / Signaling by NODAL / response to cholesterol / embryonic cranial skeleton morphogenesis / RHOD GTPase cycle / I-SMAD binding / pancreas development / aortic valve morphogenesis / insulin secretion / RND1 GTPase cycle / nuclear inner membrane / RND2 GTPase cycle / RND3 GTPase cycle / anterior/posterior pattern specification / ureteric bud development / endocardial cushion morphogenesis / organ growth / adrenal gland development / TGF-beta receptor signaling activates SMADs / SMAD binding / R-SMAD binding / mesoderm formation / negative regulation of BMP signaling pathway / RHOG GTPase cycle / anatomical structure morphogenesis / RAC2 GTPase cycle / RAC3 GTPase cycle / phosphatase binding / cell fate commitment / cis-regulatory region sequence-specific DNA binding / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / positive regulation of epithelial to mesenchymal transition / gastrulation / RAC1 GTPase cycle / transforming growth factor beta receptor signaling pathway / Downregulation of TGF-beta receptor signaling / post-embryonic development / cellular response to glucose stimulus / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / negative regulation of transforming growth factor beta receptor signaling pathway / lung development / tau protein binding / chromatin DNA binding / disordered domain specific binding / double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / nuclear membrane / DNA-binding transcription factor binding / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / cell population proliferation / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / Ub-specific processing proteases / intracellular signal transduction / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription類似検索 - 分子機能 MAN1, RNA recognition motif / MAN1, winged-helix domain / Man1/Src1, C-terminal / Man1-Src1p-C-terminal domain / Tumour Suppressor Smad4 - #10 / LEM domain / LEM domain / LEM domain profile. / in nuclear membrane-associated proteins / LEM/LEM-like domain superfamily ...MAN1, RNA recognition motif / MAN1, winged-helix domain / Man1/Src1, C-terminal / Man1-Src1p-C-terminal domain / Tumour Suppressor Smad4 - #10 / LEM domain / LEM domain / LEM domain profile. / in nuclear membrane-associated proteins / LEM/LEM-like domain superfamily / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / Tumour Suppressor Smad4 / SMAD/FHA domain superfamily / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Mothers against decapentaplegic homolog 2 / Inner nuclear membrane protein Man1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.794 Å |
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データ登録者 | Miyazono, K. / Ohno, Y. / Ito, T. / Tanokura, M. |
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資金援助 | 日本, 3件 組織 | 認可番号 | 国 |
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Japan Society for the Promotion of Science | 15K14708 | 日本 | Japan Society for the Promotion of Science | 17K19581 | 日本 | Japan Society for the Promotion of Science | 23228003 | 日本 |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2018 タイトル: Structural basis for receptor-regulated SMAD recognition by MAN1 著者: Miyazono, K.I. / Ohno, Y. / Wada, H. / Ito, T. / Fukatsu, Y. / Kurisaki, A. / Asashima, M. / Tanokura, M. |
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履歴 | 登録 | 2018年4月13日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2018年10月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年11月14日 | Group: Data collection / Database references / Structure summary カテゴリ: citation / citation_author / entity Item: _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ..._citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation_author.name / _entity.formula_weight |
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改定 1.2 | 2018年12月26日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年3月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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