登録情報 データベース : PDB / ID : 5yy4 構造の表示 ダウンロードとリンクタイトル Crystal structure of the scFv antibody 4B08 with sulfated epitope peptide 要素C-C chemokine receptor type 5 scFv 4B08 詳細キーワード IMMUNE SYSTEM / Antibody / Biomolecular recognition / MD simulations / Thermodynamics機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
chemokine (C-C motif) ligand 5 binding / negative regulation of macrophage apoptotic process / chemokine receptor activity / signaling / C-C chemokine receptor activity / phosphatidylinositol-4,5-bisphosphate phospholipase C activity / C-C chemokine binding / response to cholesterol / Chemokine receptors bind chemokines / release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ... chemokine (C-C motif) ligand 5 binding / negative regulation of macrophage apoptotic process / chemokine receptor activity / signaling / C-C chemokine receptor activity / phosphatidylinositol-4,5-bisphosphate phospholipase C activity / C-C chemokine binding / response to cholesterol / Chemokine receptors bind chemokines / release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / dendritic cell chemotaxis / Interleukin-10 signaling / Binding and entry of HIV virion / cellular defense response / coreceptor activity / cell chemotaxis / calcium-mediated signaling / chemotaxis / calcium ion transport / MAPK cascade / cell-cell signaling / actin binding / virus receptor activity / positive regulation of cytosolic calcium ion concentration / cellular response to lipopolysaccharide / G alpha (i) signalling events / cell surface receptor signaling pathway / endosome / immune response / G protein-coupled receptor signaling pathway / inflammatory response / external side of plasma membrane / apoptotic process / cell surface / identical protein binding / plasma membrane / cytoplasm 類似検索 - 分子機能 CC chemokine receptor 5 / Chemokine receptor family / : / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Immunoglobulins / Immunoglobulin-like ... CC chemokine receptor 5 / Chemokine receptor family / : / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性生物種 Mus musculus (ハツカネズミ)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.59 Å 詳細データ登録者 Caaveiro, J.M.M. / Miyanabe, K. / Tsumoto, K. 資金援助 日本, 2件 詳細 詳細を隠す組織 認可番号 国 Japan Society for the Promotion of Science 25249115 日本 Japan Society for the Promotion of Science 15K06962 日本
引用ジャーナル : Biochemistry / 年 : 2018タイトル : Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody著者 : Miyanabe, K. / Yamashita, T. / Abe, Y. / Akiba, H. / Takamatsu, Y. / Nakakido, M. / Hamakubo, T. / Ueda, T. / Caaveiro, J.M.M. / Tsumoto, K. 履歴 登録 2017年12月7日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2018年7月18日 Provider : repository / タイプ : Initial release改定 1.1 2018年7月25日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title 改定 1.2 2018年8月1日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2023年11月22日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession改定 1.4 2024年10月16日 Group : Structure summaryカテゴリ : pdbx_entry_details / pdbx_modification_feature
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