登録情報 | データベース: PDB / ID: 5x79 |
---|
タイトル | Human GST Pi conjugated with novel inhibitor, GS-ESF |
---|
要素 | Glutathione S-transferase P |
---|
キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / GSTP / covalent inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |
---|
機能・相同性 | 機能・相同性情報
S-nitrosoglutathione binding / nitric oxide storage / negative regulation of smooth muscle cell chemotaxis / negative regulation of leukocyte proliferation / TRAF2-GSTP1 complex / dinitrosyl-iron complex binding / common myeloid progenitor cell proliferation / cellular response to cell-matrix adhesion / hepoxilin biosynthetic process / glutathione derivative biosynthetic process ...S-nitrosoglutathione binding / nitric oxide storage / negative regulation of smooth muscle cell chemotaxis / negative regulation of leukocyte proliferation / TRAF2-GSTP1 complex / dinitrosyl-iron complex binding / common myeloid progenitor cell proliferation / cellular response to cell-matrix adhesion / hepoxilin biosynthetic process / glutathione derivative biosynthetic process / response to L-ascorbic acid / linoleic acid metabolic process / Glutathione conjugation / negative regulation of monocyte chemotactic protein-1 production / nitric oxide binding / JUN kinase binding / glutathione peroxidase activity / Paracetamol ADME / oligodendrocyte development / negative regulation of stress-activated MAPK cascade / negative regulation of JNK cascade / prostaglandin metabolic process / negative regulation of interleukin-1 beta production / cellular response to glucocorticoid stimulus / regulation of stress-activated MAPK cascade / Detoxification of Reactive Oxygen Species / negative regulation of acute inflammatory response / glutathione transferase / negative regulation of vascular associated smooth muscle cell proliferation / glutathione transferase activity / negative regulation of tumor necrosis factor production / protein serine/threonine kinase inhibitor activity / animal organ regeneration / negative regulation of tumor necrosis factor-mediated signaling pathway / response to amino acid / toxic substance binding / regulation of ERK1 and ERK2 cascade / negative regulation of MAPK cascade / negative regulation of fibroblast proliferation / negative regulation of canonical NF-kappaB signal transduction / glutathione metabolic process / xenobiotic metabolic process / cellular response to epidermal growth factor stimulus / positive regulation of superoxide anion generation / fatty acid binding / central nervous system development / response to reactive oxygen species / negative regulation of extrinsic apoptotic signaling pathway / negative regulation of ERK1 and ERK2 cascade / cellular response to insulin stimulus / response to estradiol / cellular response to lipopolysaccharide / response to ethanol / secretory granule lumen / vesicle / ficolin-1-rich granule lumen / Neutrophil degranulation / negative regulation of apoptotic process / negative regulation of transcription by RNA polymerase II / mitochondrion / extracellular space / extracellular exosome / extracellular region / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Glutathione S-transferase, Pi class / Glutathione S-transferase, C-terminal domain / : / Glutathione S-transferase, N-terminal domain / Glutathione transferase family / Glutathione S-transferase, C-terminal / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 - #10 / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / Glutathione S-transferase, C-terminal-like / Soluble glutathione S-transferase C-terminal domain profile. ...Glutathione S-transferase, Pi class / Glutathione S-transferase, C-terminal domain / : / Glutathione S-transferase, N-terminal domain / Glutathione transferase family / Glutathione S-transferase, C-terminal / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 - #10 / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / Glutathione S-transferase, C-terminal-like / Soluble glutathione S-transferase C-terminal domain profile. / Soluble glutathione S-transferase N-terminal domain profile. / Glutathione S-transferase, N-terminal / Glutathione S-transferase, C-terminal domain superfamily / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily / Up-down Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
---|
データ登録者 | Tomoike, F. / Shishido, Y. / Fukui, K. / Kimura, Y. / Abe, H. |
---|
資金援助 | 日本, 1件 組織 | 認可番号 | 国 |
---|
JSPS KAKENHI Grant Number | 15K12751 | 日本 |
|
---|
引用 | ジャーナル: Chem. Commun. (Camb.) / 年: 2017 タイトル: A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1). 著者: Shishido, Y. / Tomoike, F. / Kimura, Y. / Kuwata, K. / Yano, T. / Fukui, K. / Fujikawa, H. / Sekido, Y. / Murakami-Tonami, Y. / Kameda, T. / Shuto, S. / Abe, H. |
---|
履歴 | 登録 | 2017年2月24日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2017年9月13日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2017年12月6日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
---|
改定 1.2 | 2023年11月22日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|