- PDB-5x07: Crystal structure of FOXA2 DNA binding domain bound to a full con... -
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Basic information
Entry
Database: PDB / ID: 5x07
Title
Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site
Components
DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3')
DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3')
Hepatocyte nuclear factor 3-beta
Keywords
DNA BINDING PROTEIN/DNA / FOXA2 / Forkhead domain / Consensus binding site / Isothermal Titration Calorimetry / ITC / DNA BINDING PROTEIN-DNA complex
Function / homology
Function and homology information
negative regulation of transcription from RNA polymerase II promoter by glucose / positive regulation of cell-cell adhesion mediated by cadherin / negative regulation of glucokinase activity / primitive streak formation / positive regulation of embryonic development / positive regulation of transcription from RNA polymerase II promoter by glucose / response to interleukin-6 / endocrine pancreas development / regulation of insulin secretion involved in cellular response to glucose stimulus / Formation of definitive endoderm ...negative regulation of transcription from RNA polymerase II promoter by glucose / positive regulation of cell-cell adhesion mediated by cadherin / negative regulation of glucokinase activity / primitive streak formation / positive regulation of embryonic development / positive regulation of transcription from RNA polymerase II promoter by glucose / response to interleukin-6 / endocrine pancreas development / regulation of insulin secretion involved in cellular response to glucose stimulus / Formation of definitive endoderm / positive regulation of gastrulation / Formation of axial mesoderm / dopaminergic neuron differentiation / negative regulation of epithelial to mesenchymal transition / cell fate specification / regulation of blood coagulation / Regulation of gene expression in beta cells / anatomical structure morphogenesis / adult locomotory behavior / negative regulation of DNA-binding transcription factor activity / sequence-specific double-stranded DNA binding / cell junction / chromatin organization / nucleic acid binding / cell differentiation / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / protein domain specific binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / nucleus / cytoplasm Similarity search - Function
Forkhead box protein, C-terminal / HNF3 C-terminal domain / Fork-head N-terminal / Forkhead N-terminal region / Fork head domain conserved site1 / Fork head domain signature 1. / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD ...Forkhead box protein, C-terminal / HNF3 C-terminal domain / Fork-head N-terminal / Forkhead N-terminal region / Fork head domain conserved site1 / Fork head domain signature 1. / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
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