Entry Database : PDB / ID : 5wqt Structure visualization Downloads & linksTitle Structure of a protein involved in pyroptosis ComponentsGasdermin-D Details Keywords SIGNALING PROTEIN / pyrtosisFunction / homology Function and homology informationFunction Domain/homology Component
pore complex assembly / : / Release of apoptotic factors from the mitochondria / wide pore channel activity / NLRP3 inflammasome complex / cardiolipin binding / Regulation of TLR by endogenous ligand / phosphatidic acid binding / Interleukin-1 processing / phosphatidylinositol-4-phosphate binding ... pore complex assembly / : / Release of apoptotic factors from the mitochondria / wide pore channel activity / NLRP3 inflammasome complex / cardiolipin binding / Regulation of TLR by endogenous ligand / phosphatidic acid binding / Interleukin-1 processing / phosphatidylinositol-4-phosphate binding / phosphatidylserine binding / pyroptotic inflammatory response / protein secretion / Pyroptosis / Purinergic signaling in leishmaniasis infection / phosphatidylinositol-4,5-bisphosphate binding / positive regulation of interleukin-1 beta production / mitochondrial membrane / protein homooligomerization / positive regulation of inflammatory response / specific granule lumen / tertiary granule lumen / defense response to Gram-negative bacterium / ficolin-1-rich granule lumen / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / innate immune response / Neutrophil degranulation / extracellular space / extracellular region / nucleoplasm / membrane / plasma membrane / cytosol Similarity search - FunctionBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.64 Å DetailsAuthors Kuang, S. / Li, J. CitationJournal : Proc. Natl. Acad. Sci. U.S.A. / Year : 2017Title : Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis.Authors : Kuang, S. / Zheng, J. / Yang, H. / Li, S. / Duan, S. / Shen, Y. / Ji, C. / Gan, J. / Xu, X.W. / Li, J. History Deposition Nov 28, 2016 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Oct 4, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Dec 6, 2017 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.2 Feb 7, 2018 Group : Database references / Category : pdbx_related_exp_data_setRevision 1.3 Nov 8, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 1.4 Nov 15, 2023 Group : Data collection / Category : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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