登録情報 | データベース: PDB / ID: 5vd7 |
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タイトル | CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH RAC-IV-098, a MK1775 analogue |
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要素 | Wee1-like protein kinase |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / KINASE DOMAIN / CELL CYCLE / WEE1 / TRANSFERASE / INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
G2/M DNA replication checkpoint / negative regulation of G2/M transition of mitotic cell cycle / Polo-like kinase mediated events / Cyclin E associated events during G1/S transition / negative regulation of G1/S transition of mitotic cell cycle / establishment of cell polarity / positive regulation of DNA replication / Cyclin A/B1/B2 associated events during G2/M transition / Cyclin A:Cdk2-associated events at S phase entry / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex ...G2/M DNA replication checkpoint / negative regulation of G2/M transition of mitotic cell cycle / Polo-like kinase mediated events / Cyclin E associated events during G1/S transition / negative regulation of G1/S transition of mitotic cell cycle / establishment of cell polarity / positive regulation of DNA replication / Cyclin A/B1/B2 associated events during G2/M transition / Cyclin A:Cdk2-associated events at S phase entry / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / neuron projection morphogenesis / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / G2/M transition of mitotic cell cycle / microtubule cytoskeleton organization / Factors involved in megakaryocyte development and platelet production / protein tyrosine kinase activity / cell division / nucleolus / magnesium ion binding / nucleoplasm / ATP binding / nucleus / cytoplasm類似検索 - 分子機能 Wee1-like protein kinase / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain ...Wee1-like protein kinase / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.08 Å |
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データ登録者 | Zhu, J.-Y. / Schonbrunn, E. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) | UO1 HD076542 | 米国 |
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引用 | ジャーナル: to be published タイトル: Structural basis of Wee family kinase inhibition by small molecules 著者: Zhu, J.-Y. / Schonbrunn, E. |
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履歴 | 登録 | 2017年4月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年4月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.2 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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