Entry Database : PDB / ID : 5tx2 Structure visualization Downloads & linksTitle Miniature TGF-beta2 3-mutant monomer ComponentsTransforming growth factor beta-2 Details Keywords CYTOKINE / Growth factorFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of activation-induced cell death of T cells / transforming growth factor beta complex / positive regulation of GTP binding / negative regulation of alkaline phosphatase activity / : / Molecules associated with elastic fibres / regulation of timing of catagen / regulation of apoptotic process involved in outflow tract morphogenesis / substantia propria of cornea development / negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ... positive regulation of activation-induced cell death of T cells / transforming growth factor beta complex / positive regulation of GTP binding / negative regulation of alkaline phosphatase activity / : / Molecules associated with elastic fibres / regulation of timing of catagen / regulation of apoptotic process involved in outflow tract morphogenesis / substantia propria of cornea development / negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation / : / ascending aorta morphogenesis / TGF-beta receptor signaling activates SMADs / cardioblast differentiation / positive regulation of timing of catagen / positive regulation of cardioblast differentiation / : / embryonic neurocranium morphogenesis / positive regulation of heart contraction / cardiac right ventricle morphogenesis / pharyngeal arch artery morphogenesis / type III transforming growth factor beta receptor binding / transforming growth factor beta ligand-receptor complex / regulation of transforming growth factor beta2 production / positive regulation of extracellular matrix disassembly / atrial septum morphogenesis / positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation / negative regulation of macrophage cytokine production / negative regulation of keratinocyte differentiation / secondary palate development / cardiac left ventricle morphogenesis / glial cell migration / cell death / somatic stem cell division / heart valve morphogenesis / endocardial cushion fusion / atrial septum primum morphogenesis / membranous septum morphogenesis / positive regulation of integrin biosynthetic process / negative regulation of cartilage development / Platelet degranulation / positive regulation of cardiac epithelial to mesenchymal transition / cardiac epithelial to mesenchymal transition / pericyte cell differentiation / neuron fate commitment / eye development / regulation of extracellular matrix organization / cranial skeletal system development / positive regulation of stress-activated MAPK cascade / embryonic digestive tract development / neural retina development / transforming growth factor beta receptor binding / type II transforming growth factor beta receptor binding / pulmonary valve morphogenesis / outflow tract septum morphogenesis / SMAD protein signal transduction / negative regulation of immune response / ventricular trabecula myocardium morphogenesis / cell-cell junction organization / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of Ras protein signal transduction / negative regulation of release of sequestered calcium ion into cytosol / collagen fibril organization / positive regulation of cell adhesion mediated by integrin / embryonic limb morphogenesis / face morphogenesis / dopamine biosynthetic process / atrioventricular valve morphogenesis / cardiac muscle cell proliferation / endocardial cushion morphogenesis / cartilage condensation / hair follicle morphogenesis / ventricular septum morphogenesis / activation-induced cell death of T cells / positive regulation of Notch signaling pathway / activation of protein kinase activity / positive regulation of epithelial cell migration / blood vessel development / outflow tract morphogenesis / uterus development / inner ear development / hemopoiesis / positive regulation of cell division / basement membrane / hair follicle development / neuron development / epithelial to mesenchymal transition / blood vessel remodeling / BMP signaling pathway / positive regulation of cell cycle / positive regulation of epithelial to mesenchymal transition / salivary gland morphogenesis / heart morphogenesis / extrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of angiogenesis / extracellular matrix organization / neutrophil chemotaxis / transforming growth factor beta receptor signaling pathway / extracellular matrix Similarity search - Function Transforming growth factor beta-2 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain ... Transforming growth factor beta-2 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine-knot cytokine Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.82 Å DetailsAuthors Taylor, A.B. / Kim, S.K. / Hart, P.J. / Hinck, A.P. CitationJournal : J. Biol. Chem. / Year : 2017Title : An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling.Authors: Kim, S.K. / Barron, L. / Hinck, C.S. / Petrunak, E.M. / Cano, K.E. / Thangirala, A. / Iskra, B. / Brothers, M. / Vonberg, M. / Leal, B. / Richter, B. / Kodali, R. / Taylor, A.B. / Du, S. / ... Authors : Kim, S.K. / Barron, L. / Hinck, C.S. / Petrunak, E.M. / Cano, K.E. / Thangirala, A. / Iskra, B. / Brothers, M. / Vonberg, M. / Leal, B. / Richter, B. / Kodali, R. / Taylor, A.B. / Du, S. / Barnes, C.O. / Sulea, T. / Calero, G. / Hart, P.J. / Hart, M.J. / Demeler, B. / Hinck, A.P. History Deposition Nov 15, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 1, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Mar 8, 2017 Group : Database referencesRevision 1.2 May 10, 2017 Group : Database referencesRevision 1.3 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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