Entry Database : PDB / ID : 5tq1 Structure visualization Downloads & linksTitle Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor Components1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Insulin receptor DetailsKeywords HYDROLASE / SH2 / Phospholipase / phosphopeptideFunction / homology Function and homology informationFunction Domain/homology Component
response to vanadate(3-) / Insulin receptor signalling cascade / Signaling by Insulin receptor / IRS activation / calcium-dependent phospholipase C activity / yolk / : / embryonic liver development / Insulin receptor recycling / 3-phosphoinositide-dependent protein kinase binding ... response to vanadate(3-) / Insulin receptor signalling cascade / Signaling by Insulin receptor / IRS activation / calcium-dependent phospholipase C activity / yolk / : / embryonic liver development / Insulin receptor recycling / 3-phosphoinositide-dependent protein kinase binding / Signal attenuation / positive regulation of glycoprotein biosynthetic process / phosphoinositide phospholipase C / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / response to resveratrol / phospholipid catabolic process / lipoic acid binding / negative regulation of glycogen biosynthetic process / alternative mRNA splicing, via spliceosome / regulation of female gonad development / regulation of hydrogen peroxide metabolic process / phosphatidylinositol metabolic process / positive regulation of meiotic cell cycle / protein tyrosine kinase activator activity / cellular response to zinc ion starvation / insulin-like growth factor II binding / positive regulation of developmental growth / phosphatidylinositol phospholipase C activity / male sex determination / exocrine pancreas development / COP9 signalosome / insulin receptor complex / insulin-like growth factor I binding / insulin receptor activity / response to vitamin D / negative regulation of transporter activity / positive regulation of kinase activity / positive regulation of protein-containing complex disassembly / cargo receptor activity / response to manganese ion / response to food / dendritic spine maintenance / insulin binding / PTB domain binding / adrenal gland development / regulation of gluconeogenesis / negative regulation of feeding behavior / response to testosterone / activation of protein kinase activity / positive regulation of epithelial cell migration / neuronal cell body membrane / fat cell differentiation / amyloid-beta clearance / response to starvation / positive regulation of respiratory burst / peptidyl-tyrosine autophosphorylation / phosphatidylinositol-mediated signaling / positive regulation of phosphorylation / positive regulation of receptor internalization / : / regulation of embryonic development / cellular response to epidermal growth factor stimulus / insulin receptor substrate binding / positive regulation of glycogen biosynthetic process / epidermis development / cellular response to vascular endothelial growth factor stimulus / response to tumor necrosis factor / phosphatidylinositol 3-kinase binding / response to glucose / heart morphogenesis / response to glucocorticoid / release of sequestered calcium ion into cytosol / cell surface receptor protein tyrosine kinase signaling pathway / ruffle / insulin-like growth factor receptor binding / dendrite membrane / neuron projection maintenance / liver regeneration / activation of protein kinase B activity / positive regulation of glycolytic process / positive regulation of mitotic nuclear division / response to nutrient levels / cerebellum development / receptor-mediated endocytosis / positive regulation of MAP kinase activity / response to hormone / guanyl-nucleotide exchange factor activity / liver development / negative regulation of protein phosphorylation / response to activity / molecular function activator activity / caveola / epidermal growth factor receptor signaling pathway / positive regulation of glucose import / hippocampus development / receptor protein-tyrosine kinase / animal organ morphogenesis / ruffle membrane / response to insulin / peptidyl-tyrosine phosphorylation Similarity search - Function 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain ... 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / Phosphatidylinositol-specific phospholipase X-box domain profile. / Insulin receptor, trans-membrane domain / Insulin receptor trans-membrane segment / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / Tyrosine-protein kinase, insulin-like receptor / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. / SH2 domain / SHC Adaptor Protein / C2 domain / Protein kinase C conserved region 2 (CalB) / C2 domain / C2 domain profile. / Growth factor receptor cysteine-rich domain superfamily / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Fibronectin type III domain / Pleckstrin homology domain / SH3 domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / EF-Hand 1, calcium-binding site / Src homology 3 domains / EF-hand calcium-binding domain. / SH2 domain superfamily / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / EF-hand domain / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain pair / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / PH-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Bos taurus (cattle)Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.485 Å DetailsAuthors Wuttke, D.S. / McKercher, M.A. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Science Foundation (NSF, United States) MCB1121842 United States
CitationJournal : Biochemistry / Year : 2017Title : Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-gamma 1 Protein.Authors : McKercher, M.A. / Guan, X. / Tan, Z. / Wuttke, D.S. History Deposition Oct 21, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 19, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Apr 26, 2017 Group : Database referencesRevision 1.2 May 10, 2017 Group : Database referencesRevision 1.3 Sep 27, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Nov 27, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 1.6 Nov 15, 2023 Group : Data collection / Category : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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