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Yorodumi- PDB-5t9j: Crystal Structure of human GEN1 in complex with Holliday junction... -
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-Basic information
Entry | Database: PDB / ID: 5t9j | ||||||
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Title | Crystal Structure of human GEN1 in complex with Holliday junction DNA in the upper interface | ||||||
Components |
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Keywords | HYDROLASE / protein-DNA complex / Holliday junction resolvase / structure-specific endonuclease / DNA four-way junction | ||||||
Function / homology | Function and homology information resolution of mitotic recombination intermediates / resolution of DNA recombination intermediates / positive regulation of mitotic cell cycle spindle assembly checkpoint / crossover junction DNA endonuclease activity / 5'-flap endonuclease activity / regulation of centrosome duplication / Resolution of D-loop Structures through Holliday Junction Intermediates / replication fork processing / four-way junction DNA binding / double-strand break repair via homologous recombination ...resolution of mitotic recombination intermediates / resolution of DNA recombination intermediates / positive regulation of mitotic cell cycle spindle assembly checkpoint / crossover junction DNA endonuclease activity / 5'-flap endonuclease activity / regulation of centrosome duplication / Resolution of D-loop Structures through Holliday Junction Intermediates / replication fork processing / four-way junction DNA binding / double-strand break repair via homologous recombination / Hydrolases; Acting on ester bonds / centrosome / magnesium ion binding / protein homodimerization activity / nucleoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) synthetic construct (others) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / SIRAS / MIRAS / Resolution: 3.00012743215 Å | ||||||
Authors | Lee, S.-H. / Biertumpfel, C. | ||||||
Funding support | Germany, 1items
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Citation | Journal: Elife / Year: 2015 Title: Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage. Authors: Lee, S.H. / Princz, L.N. / Klugel, M.F. / Habermann, B. / Pfander, B. / Biertumpfel, C. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5t9j.cif.gz | 508.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5t9j.ent.gz | 360.2 KB | Display | PDB format |
PDBx/mmJSON format | 5t9j.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/t9/5t9j ftp://data.pdbj.org/pub/pdb/validation_reports/t9/5t9j | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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