Entry Database : PDB / ID : 5t1a Structure visualization Downloads & linksTitle Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists ComponentsChimera protein of CC chemokine receptor type 2 isoform B and T4-lysozyme,Lysozyme Details Keywords SIGNALING PROTEIN / C-C Chemokine Receptor type 2 / dual antagonist / intracellular allosteric antagonist / cooperative binding / lipidic cubic phase / membrane protein / GPCR / Structural Genomics / PSI-2 / Protein Structure Initiative / GPCR NetworkFunction / homology Function and homology informationFunction Domain/homology Component
T-helper 17 cell chemotaxis / chemokine (C-C motif) ligand 2 binding / chemokine (C-C motif) ligand 12 binding / negative regulation of eosinophil degranulation / positive regulation of immune complex clearance by monocytes and macrophages / positive regulation of CD8-positive, alpha-beta T cell extravasation / positive regulation of astrocyte chemotaxis / leukocyte adhesion to vascular endothelial cell / chemokine (C-C motif) ligand 7 binding / positive regulation of thymocyte migration ... T-helper 17 cell chemotaxis / chemokine (C-C motif) ligand 2 binding / chemokine (C-C motif) ligand 12 binding / negative regulation of eosinophil degranulation / positive regulation of immune complex clearance by monocytes and macrophages / positive regulation of CD8-positive, alpha-beta T cell extravasation / positive regulation of astrocyte chemotaxis / leukocyte adhesion to vascular endothelial cell / chemokine (C-C motif) ligand 7 binding / positive regulation of thymocyte migration / positive regulation of hematopoietic stem cell migration / monocyte extravasation / CCR2 chemokine receptor binding / negative regulation of type 2 immune response / regulation of vascular endothelial growth factor production / positive regulation of NMDA glutamate receptor activity / Beta defensins / macrophage migration / positive regulation of monocyte extravasation / regulation of macrophage migration / regulation of T cell cytokine production / neutrophil clearance / chemokine receptor activity / positive regulation of leukocyte tethering or rolling / positive regulation of T-helper 1 type immune response / inflammatory response to wounding / positive regulation of T cell chemotaxis / positive regulation of alpha-beta T cell proliferation / negative regulation of adenylate cyclase activity / cellular homeostasis / C-C chemokine receptor activity / C-C chemokine binding / chemokine-mediated signaling pathway / positive regulation of monocyte chemotaxis / Chemokine receptors bind chemokines / dendritic cell chemotaxis / regulation of T cell differentiation / Interleukin-10 signaling / monocyte chemotaxis / cell surface receptor signaling pathway via JAK-STAT / humoral immune response / hemopoiesis / blood vessel remodeling / cellular defense response / homeostasis of number of cells within a tissue / viral release from host cell by cytolysis / sensory perception of pain / positive regulation of interleukin-2 production / peptidoglycan catabolic process / negative regulation of angiogenesis / positive regulation of synaptic transmission, glutamatergic / cell chemotaxis / calcium-mediated signaling / fibrillar center / cytokine-mediated signaling pathway / response to wounding / intracellular calcium ion homeostasis / positive regulation of inflammatory response / chemotaxis / positive regulation of tumor necrosis factor production / positive regulation of type II interferon production / cell wall macromolecule catabolic process / positive regulation of T cell activation / lysozyme / lysozyme activity / positive regulation of cold-induced thermogenesis / G alpha (i) signalling events / positive regulation of cytosolic calcium ion concentration / regulation of inflammatory response / perikaryon / host cell cytoplasm / defense response to bacterium / inflammatory response / immune response / external side of plasma membrane / neuronal cell body / dendrite / perinuclear region of cytoplasm / identical protein binding / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function CC chemokine receptor 2 / Chemokine receptor family / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like ... CC chemokine receptor 2 / Chemokine receptor family / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human) Enterobacteria phage T4 (virus)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.806 Å DetailsAuthors Zheng, Y. / Qin, L. / Ortiz Zacarias, N.V. / de Vries, H. / Han, G.W. / Gustavsson, M. / Dabros, M. / Zhao, C. / Cherney, R.J. / Carter, P. ...Zheng, Y. / Qin, L. / Ortiz Zacarias, N.V. / de Vries, H. / Han, G.W. / Gustavsson, M. / Dabros, M. / Zhao, C. / Cherney, R.J. / Carter, P. / Stamos, D. / Abagyan, R. / Cherezov, V. / Stevens, R.C. / IJzerman, A.P. / Heitman, L.H. / Tebben, A. / Kufareva, I. / Handel, T.M. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) R21AI122211 United States
CitationJournal : Nature / Year : 2016Title : Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.Authors: Zheng, Y. / Qin, L. / Zacarias, N.V. / de Vries, H. / Han, G.W. / Gustavsson, M. / Dabros, M. / Zhao, C. / Cherney, R.J. / Carter, P. / Stamos, D. / Abagyan, R. / Cherezov, V. / Stevens, R.C. ... Authors : Zheng, Y. / Qin, L. / Zacarias, N.V. / de Vries, H. / Han, G.W. / Gustavsson, M. / Dabros, M. / Zhao, C. / Cherney, R.J. / Carter, P. / Stamos, D. / Abagyan, R. / Cherezov, V. / Stevens, R.C. / IJzerman, A.P. / Heitman, L.H. / Tebben, A. / Kufareva, I. / Handel, T.M. History Deposition Aug 18, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 14, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Dec 21, 2016 Group : Structure summaryRevision 1.2 Dec 28, 2016 Group : Structure summaryRevision 1.3 Jan 4, 2017 Group : Database referencesRevision 1.4 Sep 13, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Dec 11, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.6 Oct 4, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id
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