登録情報 | データベース: PDB / ID: 4mbs |
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タイトル | Crystal Structure of the CCR5 Chemokine Receptor |
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要素 | Chimera protein of C-C chemokine receptor type 5 and Rubredoxin |
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キーワード | SIGNALING PROTEIN / Human CCR5 Chemokine Receptor / anti-HIV agent / novel protein engineering / GPCR network / membrane protein / PSI-Biology / Structural Genomics / Seven transmembrane helices / G protein-coupled receptor / membrane |
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機能・相同性 | 機能・相同性情報
chemokine (C-C motif) ligand 5 binding / negative regulation of macrophage apoptotic process / alkane catabolic process / chemokine receptor activity / signaling / C-C chemokine receptor activity / phosphatidylinositol-4,5-bisphosphate phospholipase C activity / C-C chemokine binding / response to cholesterol / Chemokine receptors bind chemokines ...chemokine (C-C motif) ligand 5 binding / negative regulation of macrophage apoptotic process / alkane catabolic process / chemokine receptor activity / signaling / C-C chemokine receptor activity / phosphatidylinositol-4,5-bisphosphate phospholipase C activity / C-C chemokine binding / response to cholesterol / Chemokine receptors bind chemokines / release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / dendritic cell chemotaxis / Interleukin-10 signaling / Binding and entry of HIV virion / cellular defense response / coreceptor activity / cell chemotaxis / calcium-mediated signaling / chemotaxis / calcium ion transport / MAPK cascade / cell-cell signaling / actin binding / virus receptor activity / positive regulation of cytosolic calcium ion concentration / cellular response to lipopolysaccharide / G alpha (i) signalling events / electron transfer activity / cell surface receptor signaling pathway / endosome / immune response / G protein-coupled receptor signaling pathway / inflammatory response / iron ion binding / external side of plasma membrane / apoptotic process / cell surface / identical protein binding / plasma membrane / cytoplasm類似検索 - 分子機能 CC chemokine receptor 5 / Rubredoxin / : / Rubredoxin, iron-binding site / Rubredoxin signature. / Rubredoxin domain / Rubredoxin / Chemokine receptor family / Rubredoxin-like domain / Rubredoxin-like domain profile. ...CC chemokine receptor 5 / Rubredoxin / : / Rubredoxin, iron-binding site / Rubredoxin signature. / Rubredoxin domain / Rubredoxin / Chemokine receptor family / Rubredoxin-like domain / Rubredoxin-like domain profile. / : / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-MRV / (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / Rubredoxin / C-C chemokine receptor type 5類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
Clostridium pasteurianum (バクテリア) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.71 Å |
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データ登録者 | Tan, Q. / Zhu, Y. / Han, G.W. / Li, J. / Fenalti, G. / Liu, H. / Cherezov, V. / Stevens, R.C. / GPCR Network (GPCR) / Zhao, Q. / Wu, B. |
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引用 | ジャーナル: Science / 年: 2013 タイトル: Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. 著者: Tan, Q. / Zhu, Y. / Li, J. / Chen, Z. / Han, G.W. / Kufareva, I. / Li, T. / Ma, L. / Fenalti, G. / Li, J. / Zhang, W. / Xie, X. / Yang, H. / Jiang, H. / Cherezov, V. / Liu, H. / Stevens, R.C. / Zhao, Q. / Wu, B. |
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履歴 | 登録 | 2013年8月19日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年9月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年9月25日 | Group: Database references |
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改定 1.2 | 2013年10月9日 | Group: Database references |
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改定 1.3 | 2017年7月26日 | Group: Refinement description / Source and taxonomy / カテゴリ: entity_src_gen / software |
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改定 1.4 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.5 | 2024年11月20日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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