Entry | Database: PDB / ID: 5ocj |
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Title | Crystal structure of Ag85C bound to cyclophostin 8beta inhibitor |
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Components | Diacylglycerol acyltransferase/mycolyltransferase Ag85C |
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Keywords | TRANSFERASE / Ag85C / mycolicate / mycomembrane / TMM / TDM |
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Function / homology | Function and homology information
trehalose O-mycolyltransferase / trehalose O-mycolyltransferase activity / diacylglycerol O-acyltransferase / diacylglycerol O-acyltransferase activity / mycolate cell wall layer assembly / glycolipid biosynthetic process / zymogen binding / lipid transport / acyltransferase activity, transferring groups other than amino-acyl groups / peptidoglycan-based cell wall ...trehalose O-mycolyltransferase / trehalose O-mycolyltransferase activity / diacylglycerol O-acyltransferase / diacylglycerol O-acyltransferase activity / mycolate cell wall layer assembly / glycolipid biosynthetic process / zymogen binding / lipid transport / acyltransferase activity, transferring groups other than amino-acyl groups / peptidoglycan-based cell wall / response to antibiotic / extracellular regionSimilarity search - Function Esterase-like / Putative esterase / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Mycobacterium tuberculosis (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.8 Å |
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Authors | Viljoen, A. / Richard, M. / Nguyen, P.C. / Spilling, C.D. / Canaan, S. / Cavalier, J.F. / Blaise, M. / Kremer, L. |
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Citation | Journal: J. Biol. Chem. / Year: 2018 Title: Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Authors: Viljoen, A. / Richard, M. / Nguyen, P.C. / Fourquet, P. / Camoin, L. / Paudal, R.R. / Gnawali, G.R. / Spilling, C.D. / Cavalier, J.F. / Canaan, S. / Blaise, M. / Kremer, L. |
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History | Deposition | Jul 3, 2017 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jan 24, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Feb 21, 2018 | Group: Database references / Category: citation / Item: _citation.title |
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Revision 1.2 | Mar 7, 2018 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title |
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Revision 1.3 | Jan 17, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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