登録情報 データベース : PDB / ID : 5n48 構造の表示 ダウンロードとリンクタイトル Structure of Anticalin N9B in complex with extra-domain B of human oncofetal fibronectin 要素Fibronectin Neutrophil gelatinase-associated lipocalin 詳細キーワード PROTEIN BINDING / LIPOCALIN / ANTICALIN / LIPOCALIN-BASED BINDING PROTEIN / HUMAN FIBRONECTIN / ONCOFETAL SPLICE VARIANT / FN TYPE III DOMAIN / EXTRA-DOMAIN B / EIIIB / ED-B / EXTRACELLULAR MATRIX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of iron ion import across plasma membrane / positive regulation of hippocampal neuron apoptotic process / positive regulation of endothelial tube morphogenesis / negative regulation of monocyte activation / negative regulation of hippocampal neuron apoptotic process / negative regulation of transforming growth factor beta production / positive regulation of cell projection organization / Extracellular matrix organization / Metal sequestration by antimicrobial proteins / positive regulation of substrate-dependent cell migration, cell attachment to substrate ... positive regulation of iron ion import across plasma membrane / positive regulation of hippocampal neuron apoptotic process / positive regulation of endothelial tube morphogenesis / negative regulation of monocyte activation / negative regulation of hippocampal neuron apoptotic process / negative regulation of transforming growth factor beta production / positive regulation of cell projection organization / Extracellular matrix organization / Metal sequestration by antimicrobial proteins / positive regulation of substrate-dependent cell migration, cell attachment to substrate / siderophore transport / Fibronectin matrix formation / calcium-independent cell-matrix adhesion / response to kainic acid / neural crest cell migration involved in autonomic nervous system development / response to mycotoxin / response to blue light / fibrinogen complex / cellular response to increased oxygen levels / peptide cross-linking / response to fructose / integrin activation / cellular response to X-ray / ALK mutants bind TKIs / short-term memory / cellular response to interleukin-6 / cell-substrate junction assembly / iron ion sequestering activity / enterobactin binding / regulation of protein phosphorylation / proteoglycan binding / response to herbicide / extracellular matrix structural constituent / biological process involved in interaction with symbiont / Molecules associated with elastic fibres / MET activates PTK2 signaling / peptidase activator activity / response to iron(II) ion / Syndecan interactions / p130Cas linkage to MAPK signaling for integrins / response to muscle activity / endodermal cell differentiation / positive regulation of reactive oxygen species biosynthetic process / endoplasmic reticulum-Golgi intermediate compartment / GRB2:SOS provides linkage to MAPK signaling for Integrins / basement membrane / Non-integrin membrane-ECM interactions / cellular response to interleukin-1 / ECM proteoglycans / Integrin cell surface interactions / long-term memory / endothelial cell migration / regulation of ERK1 and ERK2 cascade / positive regulation of axon extension / cellular response to nutrient levels / collagen binding / Degradation of the extracellular matrix / extrinsic apoptotic signaling pathway in absence of ligand / Integrin signaling / extracellular matrix / positive regulation of endothelial cell migration / substrate adhesion-dependent cell spreading / platelet alpha granule lumen / cell-matrix adhesion / Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells / Iron uptake and transport / integrin-mediated signaling pathway / acute-phase response / Cell surface interactions at the vascular wall / Post-translational protein phosphorylation / wound healing / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / cellular response to nerve growth factor stimulus / response to wounding / response to virus / specific granule lumen / integrin binding / cellular response to hydrogen peroxide / Signaling by ALK fusions and activated point mutants / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of fibroblast proliferation / cellular response to amyloid-beta / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Signaling by BRAF and RAF1 fusions / cellular response to tumor necrosis factor / GPER1 signaling / Platelet degranulation / nervous system development / regulation of cell shape / heparin binding / : / positive regulation of cold-induced thermogenesis / heart development / cellular response to lipopolysaccharide / protease binding / blood microparticle 類似検索 - 分子機能 Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12 / Fibronectin type I domain / Fibronectin, type I / Fibronectin type-I domain signature. / Fibronectin type-I domain profile. / Fibronectin type 1 domain / : / Fibronectin type II domain / Fibronectin type II domain superfamily / Fibronectin type II domain ... Neutrophil gelatinase-associated lipocalin/epididymal-specific lipocalin-12 / Fibronectin type I domain / Fibronectin, type I / Fibronectin type-I domain signature. / Fibronectin type-I domain profile. / Fibronectin type 1 domain / : / Fibronectin type II domain / Fibronectin type II domain superfamily / Fibronectin type II domain / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Lipocalin / Lipocalin family conserved site / Lipocalin / cytosolic fatty-acid binding protein family / Lipocalin/cytosolic fatty-acid binding domain / Kringle-like fold / Calycin beta-barrel core domain / Calycin / Fibronectin type III domain / EGF-like domain signature 1. / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Lipocalin / Fibronectin type III / Fibronectin type III superfamily / Lipocalin signature. / Immunoglobulin-like fold / Immunoglobulins / Beta Barrel / Immunoglobulin-like / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性 Fibronectin / Neutrophil gelatinase-associated lipocalin 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.6 Å 詳細データ登録者 Schiefner, A. / Skerra, A. 引用ジャーナル : Structure / 年 : 2018タイトル : Anticalins Reveal High Plasticity in the Mode of Complex Formation with a Common Tumor Antigen.著者 : Schiefner, A. / Gebauer, M. / Richter, A. / Skerra, A. 履歴 登録 2017年2月10日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2018年2月14日 Provider : repository / タイプ : Initial release改定 1.1 2018年3月21日 Group : Database references / カテゴリ : citationItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2018年4月11日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession改定 1.4 2024年11月20日 Group : Structure summaryカテゴリ : pdbx_entry_details / pdbx_modification_feature
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