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- PDB-5ksu: Crystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution -

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Basic information

Entry
Database: PDB / ID: 5ksu
TitleCrystal structure of HLA-DQ2.5-CLIP1 at 2.73 resolution
Components
  • HLA class II histocompatibility antigen gamma chain
  • HLA class II histocompatibility antigen, DQ alpha 1 chain
  • MHC class II HLA-DQ-beta-1
KeywordsIMMUNE SYSTEM / HLA / MHC / DQ2.5 / CLIP / celiac disease
Function / homology
Function and homology information


negative regulation of peptide secretion / macrophage migration inhibitory factor signaling pathway / NOS2-CD74 complex / MHC class II protein binding, via antigen binding groove / antigen processing and presentation of endogenous antigen / positive regulation of dendritic cell antigen processing and presentation / negative regulation of T cell differentiation / macrophage migration inhibitory factor binding / positive regulation of macrophage migration inhibitory factor signaling pathway / protein trimerization ...negative regulation of peptide secretion / macrophage migration inhibitory factor signaling pathway / NOS2-CD74 complex / MHC class II protein binding, via antigen binding groove / antigen processing and presentation of endogenous antigen / positive regulation of dendritic cell antigen processing and presentation / negative regulation of T cell differentiation / macrophage migration inhibitory factor binding / positive regulation of macrophage migration inhibitory factor signaling pathway / protein trimerization / macrophage migration inhibitory factor receptor complex / positive regulation of cytokine-mediated signaling pathway / T cell activation involved in immune response / positive regulation of type 2 immune response / T cell selection / negative thymic T cell selection / positive regulation of prostaglandin biosynthetic process / negative regulation of viral entry into host cell / MHC class II receptor activity / MHC class II protein binding / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / negative regulation of mature B cell apoptotic process / positive thymic T cell selection / positive regulation of monocyte differentiation / CD4 receptor binding / positive regulation of kinase activity / positive regulation of chemokine (C-X-C motif) ligand 2 production / positive regulation of neutrophil chemotaxis / vacuole / positive regulation of macrophage cytokine production / prostaglandin biosynthetic process / positive regulation of T cell differentiation / cytokine receptor activity / regulation of macrophage activation / transport vesicle membrane / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / nitric-oxide synthase binding / cytokine binding / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / response to type II interferon / antigen processing and presentation / negative regulation of DNA damage response, signal transduction by p53 class mediator / chaperone cofactor-dependent protein refolding / Generation of second messenger molecules / PD-1 signaling / immunoglobulin mediated immune response / positive regulation of chemokine production / positive regulation of B cell proliferation / protein folding chaperone / MHC class II antigen presentation / multivesicular body / negative regulation of cell migration / lysosomal lumen / trans-Golgi network membrane / positive regulation of interleukin-8 production / lumenal side of endoplasmic reticulum membrane / Cell surface interactions at the vascular wall / intracellular protein transport / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / peptide antigen binding / antigen processing and presentation of exogenous peptide antigen via MHC class II / endocytic vesicle membrane / positive regulation of interleukin-6 production / positive regulation of peptidyl-tyrosine phosphorylation / Interferon gamma signaling / positive regulation of immune response / positive regulation of fibroblast proliferation / late endosome / Downstream TCR signaling / positive regulation of T cell activation / MHC class II protein complex binding / late endosome membrane / amyloid-beta binding / protein-containing complex assembly / positive regulation of canonical NF-kappaB signal transduction / adaptive immune response / positive regulation of MAPK cascade / positive regulation of viral entry into host cell / positive regulation of ERK1 and ERK2 cascade / lysosome / protein stabilization / endosome membrane / positive regulation of protein phosphorylation / immune response / lysosomal membrane / external side of plasma membrane / Golgi membrane / positive regulation of gene expression / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / cell surface / protein-containing complex / extracellular exosome / identical protein binding / membrane / nucleus
Similarity search - Function
MHC class II-associated invariant chain, trimerisation / MHC class II-associated invariant chain/CLIP, MHC II-interacting / MHC class II-associated invariant chain / MHC class II-associated invariant chain, trimerisation domain superfamily / HLA class II histocompatibility antigen, gamma subunit / Class II MHC-associated invariant chain trimerisation domain / CLIP, MHC2 interacting / Thyroglobulin type-1 repeat signature. / Thyroglobulin type-1 / Thyroglobulin type-1 superfamily ...MHC class II-associated invariant chain, trimerisation / MHC class II-associated invariant chain/CLIP, MHC II-interacting / MHC class II-associated invariant chain / MHC class II-associated invariant chain, trimerisation domain superfamily / HLA class II histocompatibility antigen, gamma subunit / Class II MHC-associated invariant chain trimerisation domain / CLIP, MHC2 interacting / Thyroglobulin type-1 repeat signature. / Thyroglobulin type-1 / Thyroglobulin type-1 superfamily / Thyroglobulin type-1 repeat / Thyroglobulin type-1 domain profile. / Thyroglobulin type I repeats. / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Roll / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta / Alpha Beta
Similarity search - Domain/homology
MHC class II HLA-DQ-beta-1 / HLA class II histocompatibility antigen, DQ alpha 1 chain / HLA class II histocompatibility antigen gamma chain / HLA class II histocompatibility antigen DQ beta chain
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.73 Å
AuthorsNguyen, T.-B. / Jayaraman, P. / Bergseng, E. / Madhusudhan, M.S. / Kim, C.-Y. / Sollid, L.M.
CitationJournal: J. Biol. Chem. / Year: 2017
Title: Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides.
Authors: Nguyen, T.B. / Jayaraman, P. / Bergseng, E. / Madhusudhan, M.S. / Kim, C.Y. / Sollid, L.M.
History
DepositionJul 10, 2016Deposition site: RCSB / Processing site: RCSB
Revision 1.0Apr 5, 2017Provider: repository / Type: Initial release
Revision 1.1Apr 18, 2018Group: Data collection / Database references / Category: citation / citation_author
Item: _citation.journal_abbrev / _citation.journal_volume ..._citation.journal_abbrev / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name
Revision 1.2Oct 4, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: HLA class II histocompatibility antigen, DQ alpha 1 chain
B: MHC class II HLA-DQ-beta-1
C: HLA class II histocompatibility antigen gamma chain
D: HLA class II histocompatibility antigen, DQ alpha 1 chain
E: MHC class II HLA-DQ-beta-1
F: HLA class II histocompatibility antigen gamma chain


Theoretical massNumber of molelcules
Total (without water)95,7686
Polymers95,7686
Non-polymers00
Water2,090116
1
A: HLA class II histocompatibility antigen, DQ alpha 1 chain
B: MHC class II HLA-DQ-beta-1
C: HLA class II histocompatibility antigen gamma chain


Theoretical massNumber of molelcules
Total (without water)47,8843
Polymers47,8843
Non-polymers00
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area7400 Å2
ΔGint-45 kcal/mol
Surface area18030 Å2
MethodPISA
2
D: HLA class II histocompatibility antigen, DQ alpha 1 chain
E: MHC class II HLA-DQ-beta-1
F: HLA class II histocompatibility antigen gamma chain


Theoretical massNumber of molelcules
Total (without water)47,8843
Polymers47,8843
Non-polymers00
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area7540 Å2
ΔGint-45 kcal/mol
Surface area17880 Å2
MethodPISA
Unit cell
Length a, b, c (Å)128.860, 69.210, 146.690
Angle α, β, γ (deg.)90.00, 110.29, 90.00
Int Tables number5
Space group name H-MC121

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Components

#1: Protein HLA class II histocompatibility antigen, DQ alpha 1 chain / DC-1 alpha chain / DC-alpha / HLA-DCA / MHC class II DQA1


Mass: 22423.109 Da / Num. of mol.: 2 / Fragment: UNP residues 1-193
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-DQA1 / Production host: unidentified baculovirus / References: UniProt: P01909
#2: Protein MHC class II HLA-DQ-beta-1


Mass: 23784.760 Da / Num. of mol.: 2 / Fragment: UNP residues 1-198
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-DQB1 / Production host: unidentified baculovirus / References: UniProt: O19712, UniProt: Q5Y7D3*PLUS
#3: Protein/peptide HLA class II histocompatibility antigen gamma chain


Mass: 1676.118 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: unidentified baculovirus / References: UniProt: P04233*PLUS
#4: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 116 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.2 Å3/Da / Density % sol: 61.6 %
Crystal growTemperature: 291 K / Method: vapor diffusion, hanging drop / pH: 6.5
Details: PEG 8000, ammonium sulphate, sodium cacodylate, glycerol

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: SSRL / Beamline: BL12-2 / Wavelength: 0.9795 Å
DetectorType: PSI PILATUS 6M / Detector: PIXEL / Date: Dec 16, 2010
RadiationMonochromator: Si(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9795 Å / Relative weight: 1
ReflectionResolution: 2.73→39.26 Å / Num. obs: 30494 / % possible obs: 93.7 % / Redundancy: 3.5 % / Rmerge(I) obs: 0.1 / Net I/σ(I): 11.7
Reflection shellResolution: 2.73→2.8 Å / Redundancy: 3.5 % / Rmerge(I) obs: 0.998 / Num. measured obs: 2060 / % possible all: 86

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Processing

Software
NameVersionClassification
PHENIXdev_1137refinement
HKL-2000data reduction
XSCALEdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 1S9V

1s9v


Resolution: 2.73→39.164 Å / SU ML: 0.38 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 31.19
RfactorNum. reflection% reflection
Rfree0.2491 1525 5 %
Rwork0.19 --
obs0.1931 30478 93.75 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Refinement stepCycle: LAST / Resolution: 2.73→39.164 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6023 0 0 116 6139
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.016181
X-RAY DIFFRACTIONf_angle_d1.3168411
X-RAY DIFFRACTIONf_dihedral_angle_d15.3582239
X-RAY DIFFRACTIONf_chiral_restr0.08945
X-RAY DIFFRACTIONf_plane_restr0.0061079
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.7299-2.8180.38261260.31612383X-RAY DIFFRACTION85
2.818-2.91870.32141370.27372616X-RAY DIFFRACTION93
2.9187-3.03550.3531420.26222681X-RAY DIFFRACTION97
3.0355-3.17360.30731430.23792719X-RAY DIFFRACTION98
3.1736-3.34080.28921420.21952708X-RAY DIFFRACTION97
3.3408-3.550.28651400.19932644X-RAY DIFFRACTION95
3.55-3.82390.25221390.18932649X-RAY DIFFRACTION94
3.8239-4.20830.25031270.1742417X-RAY DIFFRACTION86
4.2083-4.81630.18451440.13272735X-RAY DIFFRACTION97
4.8163-6.06440.20951440.15362724X-RAY DIFFRACTION96
6.0644-39.16820.21751410.19712677X-RAY DIFFRACTION92
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
17.86640.7643-4.50741.9673-2.44428.35860.22270.7847-0.9414-0.2307-0.1843-0.25940.53030.3205-0.06030.31640.09320.02770.294-0.06350.3288-4.560114.204543.172
23.67951.50660.93222.83480.3271.7684-0.04-0.4806-0.18880.0079-0.05850.179-0.02430.0070.09180.17280.06380.0250.1978-0.01360.1751-14.48089.320158.0412
31.38190.2890.67141.66550.79860.9765-0.2507-0.46490.1330.29210.1458-0.0042-0.19250.0271-0.1240.1810.2890.05170.4096-0.30430.2799-5.697418.616662.2607
47.08144.96454.03635.5875.17495.0286-0.2523-0.1850.4701-0.2015-0.02520.9696-0.6412-0.95580.46340.34530.0971-0.04340.3737-0.00580.316-27.205510.86851.5498
54.9019-0.75945.14284.4455-4.78389.16990.6140.7258-0.603-0.16340.28040.26540.2713-0.0361-0.8530.37930.1051-0.14680.4725-0.15360.5758-22.3319-6.379844.2281
63.3375-1.6608-0.68284.9253-1.64231.9075-0.3463-0.01790.20210.1972-0.158-0.2081-0.06080.74650.27130.17530.09390.07390.40080.11640.22547.3019-6.602460.3474
72.1531-0.16470.58040.65210.05450.33510.0652-0.3303-0.3484-0.08030.10270.01720.1984-0.3164-0.20680.26770.07340.00690.26220.06740.3276-6.1671-6.377858.1298
87.63-4.6622-2.1973.24280.58184.10580.0211-0.8371-1.64251.18120.36290.25810.96650.3824-0.32930.6676-0.089-0.14040.4340.12790.5447-4.4658-9.294669.4833
91.9456-1.33751.18711.2312-0.27952.26430.0104-0.2014-0.3862-0.1446-0.28820.04570.6413-0.417-0.19270.3001-0.01710.02530.24290.16330.2924-3.9841-5.141558.5915
106.5648-1.96981.93163.1276-0.93112.35830.2970.3464-1.3573-0.0069-0.08270.07930.78570.271-0.17670.45940.1805-0.0930.428-0.02170.7052-4.831-14.827656.6784
111.981-0.85180.45280.8462-0.30972.31240.1182-0.1745-0.2703-0.2618-0.0186-0.01510.1454-0.2159-0.15910.24680.1298-0.02330.3722-0.00610.2003-16.78966.909246.4883
121.60150.08930.97764.4389-0.43162.071-0.04250.05770.30040.2123-0.327-0.3441-0.33090.2073-0.36210.2380.18190.0140.3113-0.05110.1505-10.257416.6740.6104
132.6233-0.14840.30645.2414-1.46812.99030.27350.64-0.1658-0.3499-0.3590.3775-0.0105-0.06460.05260.43720.2381-0.05320.4834-0.03770.27-18.988312.556336.2933
141.11341.6090.24452.3873-0.10923.1980.09690.1147-0.39890.37430.27780.021-0.394-0.9001-0.27480.37160.1195-0.09520.6033-0.04910.3111-28.778614.858236.1497
158.6993-0.3854.7420.3012-0.84554.0035-0.2358-0.39670.96760.07820.08210.1846-0.846-0.67510.07220.49590.1549-0.01860.2784-0.04480.4667-20.034526.458542.3321
162.7275-2.41290.75412.7939-0.41791.2644-0.17930.18920.36860.3433-0.0263-0.3917-0.17210.39780.06880.35570.05330.04270.00830.04740.25238.783110.319753.7618
175.7163-4.3025-5.35033.39294.03495.030.73531.10710.5512-0.8052-0.3581-0.3605-0.39470.0223-0.37620.3311-0.01050.03860.4806-0.02550.329918.55494.629947.2299
182.0728-0.2632-0.49061.0880.11860.65970.27950.4117-0.3258-0.1315-0.38190.03570.11450.4475-0.03330.23470.1905-0.03290.48380.02060.209914.204-0.896148.3962
192.9998-2.9274-1.57153.39432.08251.55010.40510.27960.517-0.2984-0.0625-0.78410.0450.77160.28230.25170.51930.12690.6401-0.08850.547929.4948-4.545949.4236
209.5649-5.1312.05638.7319-2.58734.86710.10370.30981.04460.60610.0734-1.1302-0.0680.3116-0.2520.25970.01380.00390.4024-0.12640.432624.0685.759354.1086
211.6975-0.4167-0.37761.9240.29990.9316-0.0296-0.11650.3830.47810.18980.202-0.0741-0.15230.62110.41590.41440.0240.4488-0.23070.2571-18.395321.366752.0284
222.6233-0.3844-0.12552.1646-1.91363.4763-0.0184-0.1672-0.03450.30370.2467-0.27370.057-0.1181-0.23790.18860.0481-0.01950.2736-0.00220.17593.1498-9.766423.8086
235.2538-1.21941.14532.8657-1.14354.00510.26260.1013-0.6998-0.28890.15530.11390.55140.01070.06290.44130.16720.01910.5754-0.03430.16770.6862-13.324713.2379
241.7131-0.67071.7491.5228-2.97815.98840.25410.4582-0.1418-0.6873-0.22440.04220.78420.3843-0.33390.3333-0.008-0.01980.86260.02030.14073.6035-8.67164.7327
253.93940.28610.51571.42940.43371.60150.6834-0.4409-0.46210.05530.0271-0.14540.78520.3208-0.0030.51820.2224-0.07940.4750.00740.33597.8783-20.754928.9759
262.88280.3325-1.60015.9938-1.03851.01-0.22430.61060.1919-0.5836-0.12880.7825-0.0101-0.7620.36160.3227-0.0817-0.0450.6997-0.03540.4493-24.2763-7.038817.3645
271.1148-1.48470.22762.104-0.84821.7085-0.05950.0051-0.52720.22050.03790.55150.1256-0.70810.01830.2787-0.09250.0990.67420.08040.3722-15.2738-15.840322.764
284.68722.3019-5.38586.6274-2.14756.2351-0.29090.6025-1.4209-0.37510.64320.46230.8732-1.8361-0.04290.5125-0.1145-0.17531.02720.07470.7551-22.0448-22.018615.3063
293.20850.60181.95960.16130.15472.14540.2803-0.5358-0.21490.11710.0834-0.23210.42630.3218-0.16740.45970.2106-0.02110.4022-0.07280.2191-3.8794-10.800125.982
304.1272-0.4247-0.63841.82070.67540.44320.494-0.0956-1.18160.0955-0.39060.66320.4726-1.1599-0.14850.4044-0.14070.01860.87380.01780.5656-23.36-16.114718.0403
317.2297-1.91781.95712.9738-0.52323.0610.2625-0.1725-0.5090.28890.22831.17220.0729-0.774-0.43440.4315-0.1090.12351.32020.0920.6666-22.0372-17.474228.1577
322.4909-0.35740.71823.44510.1681.24950.0481-0.152-0.26510.58490.17150.05030.13770.1096-0.26790.30750.1426-0.02990.4653-0.03550.15244.3952-12.19327.5545
331.730.1929-0.6186.1573-4.30196.9522-0.14540.29140.20920.06670.21360.209-0.52330.0060.0850.21070.0739-0.02710.5943-0.06720.30299.5686-0.443325.1588
343.15091.1318-0.2662.6593-0.89982.91820.07710.0379-0.19830.30.085-0.11440.00360.2817-0.13750.2840.1341-0.01230.49140.00790.210516.3046-8.439133.4902
357.5884-2.74883.34124.3283-2.87445.92580.5480.38160.2458-0.43930.0062-0.18040.10840.8772-0.34640.35030.15260.03240.8486-0.0340.24722.1916-4.265321.0038
366.0116-2.5294-0.58666.6152-0.54372.14020.08090.02540.676-0.45440.15260.1022-0.15980.1657-0.23170.297-0.11650.04320.57680.06590.23848.6361.728310.6045
377.6182-0.4737-1.15841.64440.96931.14720.11690.47660.4058-0.2908-0.1149-0.0954-0.59790.09040.16240.40350.1996-0.00880.63720.09530.2045-7.02294.42017.8461
383.3694-1.4142-1.74391.00751.10042.15970.05810.04080.1427-0.153-0.10290.0713-0.0183-0.44890.060.38540.2406-0.04170.6962-0.05860.2165-23.16978.645817.2361
395.8341-0.44094.97870.6651-0.54444.2948-0.55010.04750.390.22020.15390.219-1.214-0.39780.37980.55420.1603-0.07970.67210.02540.3251-26.796817.693223.9598
404.0298-1.26420.36221.9538-0.29920.7557-0.29890.403-0.0855-0.2776-0.15180.155-0.3423-0.6279-0.31070.34410.2523-0.15320.8054-0.08190.1612-24.09886.169819.8431
412.6974-2.5403-0.25312.91330.64780.3660.24080.37970.6837-0.0183-0.0143-0.3471-0.3566-0.44380.04010.5320.3016-0.07380.8670.02040.261-23.077514.063711.6648
421.56310.5226-1.52651.07950.55822.7427-0.08980.2746-0.00080.02990.2599-0.30980.05490.3958-0.17410.20050.1240.12860.6836-0.12560.180914.4865-10.769615.604
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'A' and (resid 0 through 9A)
2X-RAY DIFFRACTION2chain 'A' and (resid 10 through 43 )
3X-RAY DIFFRACTION3chain 'A' and (resid 44 through 55 )
4X-RAY DIFFRACTION4chain 'A' and (resid 56 through 76 )
5X-RAY DIFFRACTION5chain 'A' and (resid 77 through 87 )
6X-RAY DIFFRACTION6chain 'A' and (resid 88 through 101 )
7X-RAY DIFFRACTION7chain 'A' and (resid 102 through 123 )
8X-RAY DIFFRACTION8chain 'A' and (resid 124 through 134 )
9X-RAY DIFFRACTION9chain 'A' and (resid 135 through 166 )
10X-RAY DIFFRACTION10chain 'A' and (resid 167 through 181 )
11X-RAY DIFFRACTION11chain 'B' and (resid 3 through 18 )
12X-RAY DIFFRACTION12chain 'B' and (resid 19 through 32 )
13X-RAY DIFFRACTION13chain 'B' and (resid 33 through 51 )
14X-RAY DIFFRACTION14chain 'B' and (resid 52 through 63 )
15X-RAY DIFFRACTION15chain 'B' and (resid 64 through 78 )
16X-RAY DIFFRACTION16chain 'B' and (resid 79 through 122 )
17X-RAY DIFFRACTION17chain 'B' and (resid 123 through 133 )
18X-RAY DIFFRACTION18chain 'B' and (resid 134 through 162 )
19X-RAY DIFFRACTION19chain 'B' and (resid 163 through 176 )
20X-RAY DIFFRACTION20chain 'B' and (resid 177 through 190 )
21X-RAY DIFFRACTION21chain 'C' and (resid -3 through 10 )
22X-RAY DIFFRACTION22chain 'D' and (resid 0 through 18 )
23X-RAY DIFFRACTION23chain 'D' and (resid 19 through 45 )
24X-RAY DIFFRACTION24chain 'D' and (resid 46 through 55 )
25X-RAY DIFFRACTION25chain 'D' and (resid 56 through 87 )
26X-RAY DIFFRACTION26chain 'D' and (resid 88 through 101 )
27X-RAY DIFFRACTION27chain 'D' and (resid 102 through 123 )
28X-RAY DIFFRACTION28chain 'D' and (resid 124 through 134 )
29X-RAY DIFFRACTION29chain 'D' and (resid 135 through 146 )
30X-RAY DIFFRACTION30chain 'D' and (resid 147 through 166 )
31X-RAY DIFFRACTION31chain 'D' and (resid 167 through 181 )
32X-RAY DIFFRACTION32chain 'E' and (resid 3 through 18 )
33X-RAY DIFFRACTION33chain 'E' and (resid 19 through 32 )
34X-RAY DIFFRACTION34chain 'E' and (resid 33 through 64 )
35X-RAY DIFFRACTION35chain 'E' and (resid 65 through 77 )
36X-RAY DIFFRACTION36chain 'E' and (resid 78 through 88 )
37X-RAY DIFFRACTION37chain 'E' and (resid 89 through 97 )
38X-RAY DIFFRACTION38chain 'E' and (resid 98 through 133 )
39X-RAY DIFFRACTION39chain 'E' and (resid 134 through 144 )
40X-RAY DIFFRACTION40chain 'E' and (resid 145 through 170 )
41X-RAY DIFFRACTION41chain 'E' and (resid 171 through 189 )
42X-RAY DIFFRACTION42chain 'F' and (resid -3 through 10 )

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