Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
要素
(Insulin) x 2
(MONOCLONAL ANTIBODY FAB 83-14 - ...) x 2
Insulin receptor,Insulin receptor
キーワード
Hormone/Hormone Receptor/Immune System / Cell surface receptor/immune system / insulin receptor / IR ectodomain / CT peptide / HORMONE-HORMONE RECEPTOR-IMMUNE SYSTEM COMPLEX
機能・相同性
機能・相同性情報
estradiol secretion / negative regulation of lactation / positive regulation of blood circulation / glucose import in response to insulin stimulus / positive regulation of cell maturation / positive regulation of lactation / response to L-arginine / positive regulation of mammary gland epithelial cell proliferation / regulation of female gonad development / positive regulation of meiotic cell cycle ...estradiol secretion / negative regulation of lactation / positive regulation of blood circulation / glucose import in response to insulin stimulus / positive regulation of cell maturation / positive regulation of lactation / response to L-arginine / positive regulation of mammary gland epithelial cell proliferation / regulation of female gonad development / positive regulation of meiotic cell cycle / negative regulation of appetite / response to butyrate / positive regulation of developmental growth / insulin-like growth factor II binding / male sex determination / exocrine pancreas development / insulin receptor complex / insulin-like growth factor I binding / insulin receptor activity / feeding behavior / response to growth hormone / positive regulation of protein-containing complex disassembly / cargo receptor activity / response to food / dendritic spine maintenance / insulin binding / PTB domain binding / adrenal gland development / positive regulation of Rho protein signal transduction / neuronal cell body membrane / Signaling by Insulin receptor / IRS activation / activation of protein kinase activity / amyloid-beta clearance / positive regulation of respiratory burst / positive regulation of peptide hormone secretion / positive regulation of receptor internalization / regulation of embryonic development / transport across blood-brain barrier / protein secretion / insulin receptor substrate binding / positive regulation of glycogen biosynthetic process / epidermis development / Signal attenuation / negative regulation of lipid catabolic process / phosphatidylinositol 3-kinase binding / response to glucose / heart morphogenesis / dendrite membrane / Insulin receptor recycling / neuron projection maintenance / positive regulation of glycolytic process / activation of protein kinase B activity / positive regulation of mitotic nuclear division / Insulin receptor signalling cascade / response to nutrient levels / receptor-mediated endocytosis / learning / caveola / positive regulation of protein secretion / positive regulation of glucose import / insulin-like growth factor receptor binding / positive regulation of MAP kinase activity / insulin receptor binding / positive regulation of insulin secretion / hormone activity / receptor internalization / receptor protein-tyrosine kinase / memory / cellular response to growth factor stimulus / peptidyl-tyrosine phosphorylation / cellular response to insulin stimulus / glucose metabolic process / male gonad development / positive regulation of nitric oxide biosynthetic process / late endosome / insulin receptor signaling pathway / glucose homeostasis / amyloid-beta binding / response to heat / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / protein tyrosine kinase activity / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / lysosome / receptor complex / endosome membrane / positive regulation of cell migration / symbiont entry into host cell / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / protein domain specific binding / axon / external side of plasma membrane / protein phosphorylation / positive regulation of cell population proliferation / protein-containing complex binding / positive regulation of gene expression / regulation of DNA-templated transcription 類似検索 - 分子機能
Insulin receptor, trans-membrane domain / Insulin receptor trans-membrane segment / Tyrosine-protein kinase, insulin-like receptor / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. / Insulin / Insulin family / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin family signature. ...Insulin receptor, trans-membrane domain / Insulin receptor trans-membrane segment / Tyrosine-protein kinase, insulin-like receptor / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. / Insulin / Insulin family / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin family signature. / Insulin-like / Insulin / insulin-like growth factor / relaxin family. / Insulin-like superfamily / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Growth factor receptor cysteine-rich domain superfamily / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
解像度: 4.4→42.49 Å / Cor.coef. Fo:Fc: 0.9144 / Cor.coef. Fo:Fc free: 0.8767 / 交差検証法: THROUGHOUT / σ(F): 0 / SU Rfree Blow DPI: 1.152 詳細: The apparent discrepancy in calculated Rwork/Rfree from reported by depositor is use of expectation values in calculation by BUSTER