Entry Database : PDB / ID : 5j8h Structure visualization Downloads & linksTitle Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase ComponentsCalmodulin Eukaryotic elongation factor 2 kinase DetailsKeywords METAL BINDING PROTEIN/TRANSFERASE / Calmodulin eEF2K complex kinase / METAL BINDING PROTEIN-TRANSFERASE complexFunction / homology Function and homology informationFunction Domain/homology Component
elongation factor 2 kinase / elongation factor-2 kinase activity / response to prolactin / regulation of translation at postsynapse / regulation of protein autophosphorylation / myosin heavy chain kinase activity / myosin II filament disassembly / cellular response to anoxia / response to differentiation-inducing factor 1 / actomyosin contractile ring ... elongation factor 2 kinase / elongation factor-2 kinase activity / response to prolactin / regulation of translation at postsynapse / regulation of protein autophosphorylation / myosin heavy chain kinase activity / myosin II filament disassembly / cellular response to anoxia / response to differentiation-inducing factor 1 / actomyosin contractile ring / positive regulation of dendritic spine morphogenesis / translation factor activity, RNA binding / : / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / positive regulation of synapse assembly / CaM pathway / Cam-PDE 1 activation / Sodium/Calcium exchangers / regulation of synaptic vesicle endocytosis / Calmodulin induced events / Reduction of cytosolic Ca++ levels / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Activation of Ca-permeable Kainate Receptor / Loss of phosphorylation of MECP2 at T308 / CREB1 phosphorylation through the activation of Adenylate Cyclase / PKA activation / negative regulation of high voltage-gated calcium channel activity / CaMK IV-mediated phosphorylation of CREB / translational elongation / Glycogen breakdown (glycogenolysis) / positive regulation of cyclic-nucleotide phosphodiesterase activity / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / regulation of synaptic vesicle exocytosis / CLEC7A (Dectin-1) induces NFAT activation / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / Activation of RAC1 downstream of NMDARs / response to corticosterone / nitric-oxide synthase binding / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of cell communication by electrical coupling involved in cardiac conduction / Negative regulation of NMDA receptor-mediated neuronal transmission / negative regulation of peptidyl-threonine phosphorylation / Synthesis of IP3 and IP4 in the cytosol / Unblocking of NMDA receptors, glutamate binding and activation / Phase 0 - rapid depolarisation / protein phosphatase activator activity / mTORC1-mediated signalling / RHO GTPases activate PAKs / positive regulation of endocytosis / positive regulation of phosphoprotein phosphatase activity / Ion transport by P-type ATPases / Long-term potentiation / Uptake and function of anthrax toxins / Calcineurin activates NFAT / Regulation of MECP2 expression and activity / adenylate cyclase binding / catalytic complex / DARPP-32 events / detection of calcium ion / regulation of cardiac muscle contraction / negative regulation of ryanodine-sensitive calcium-release channel activity / Smooth Muscle Contraction / RHO GTPases activate IQGAPs / calcium channel inhibitor activity / cellular response to interferon-beta / positive regulation of DNA binding / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / Protein methylation / phosphatidylinositol 3-kinase binding / eNOS activation / Activation of AMPK downstream of NMDARs / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / enzyme regulator activity / cellular response to cAMP / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / positive regulation of protein dephosphorylation / Ion homeostasis / regulation of calcium-mediated signaling / regulation of ryanodine-sensitive calcium-release channel activity / titin binding / positive regulation of protein autophosphorylation / voltage-gated potassium channel complex / sperm midpiece / cellular response to brain-derived neurotrophic factor stimulus / calcium channel complex / response to amphetamine / activation of adenylate cyclase activity / cellular response to calcium ion / substantia nigra development / adenylate cyclase activator activity / Ras activation upon Ca2+ influx through NMDA receptor / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / FCERI mediated Ca+2 mobilization Similarity search - Function Eukaryotic elongation factor 2 kinase / : / MHCK/EF2 kinase / Alpha-kinase family / Alpha-type protein kinase domain profile. / Alpha-kinase family / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. ... Eukaryotic elongation factor 2 kinase / : / MHCK/EF2 kinase / Alpha-kinase family / Alpha-type protein kinase domain profile. / Alpha-kinase family / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Tetratricopeptide-like helical domain superfamily / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method SOLUTION NMR / simulated annealing DetailsAuthors Alphonse, S. / Lee, K. / Piserchio, A. / Tavares, C.D.J. / Giles, D.H. / Wellmann, R.M. / Dalby, K.N. / Ghose, R. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM084278 United States National Institutes of Health/National Institute on Minority Health and Health Disparities (NIH/NIMHD) G12 MD007603 United States
CitationJournal : Structure / Year : 2016Title : Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.Authors : Lee, K. / Alphonse, S. / Piserchio, A. / Tavares, C.D. / Giles, D.H. / Wellmann, R.M. / Dalby, K.N. / Ghose, R. History Deposition Apr 7, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 7, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 21, 2016 Group : Database referencesRevision 1.2 Sep 20, 2017 Group : Author supporting evidence / Database references / Structure summaryCategory : citation / entity / pdbx_audit_supportItem : _citation.journal_id_CSD / _entity.pdbx_number_of_molecules / _pdbx_audit_support.funding_organizationRevision 1.3 Dec 18, 2019 Group : Author supporting evidence / Data collectionCategory : pdbx_audit_support / pdbx_nmr_software / pdbx_nmr_spectrometerItem : _pdbx_audit_support.funding_organization / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.modelRevision 1.4 Jun 14, 2023 Group : Database references / Other / Category : database_2 / pdbx_database_statusItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_dataRevision 1.5 May 15, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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