- PDB-5irm: Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form2) -
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IDまたはキーワード:
読み込み中...
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基本情報
登録情報
データベース: PDB / ID: 5irm
タイトル
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form2)
要素
Uncharacterized protein
キーワード
IMMUNE SYSTEM / NOD2 / innate immunity
機能・相同性
機能・相同性情報
biosynthetic process of antibacterial peptides active against Gram-positive bacteria / detection of muramyl dipeptide / muramyl dipeptide binding / positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria / regulation of neutrophil chemotaxis / negative regulation of interleukin-18 production / negative regulation of T cell mediated immunity / host-mediated modulation of intestinal microbiota composition / positive regulation of dendritic cell antigen processing and presentation / negative regulation of toll-like receptor 2 signaling pathway ...biosynthetic process of antibacterial peptides active against Gram-positive bacteria / detection of muramyl dipeptide / muramyl dipeptide binding / positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria / regulation of neutrophil chemotaxis / negative regulation of interleukin-18 production / negative regulation of T cell mediated immunity / host-mediated modulation of intestinal microbiota composition / positive regulation of dendritic cell antigen processing and presentation / negative regulation of toll-like receptor 2 signaling pathway / regulation of appetite / toll-like receptor 2 signaling pathway / negative regulation of macrophage apoptotic process / intestinal stem cell homeostasis / positive regulation of humoral immune response mediated by circulating immunoglobulin / maintenance of gastrointestinal epithelium / negative regulation of macrophage cytokine production / positive regulation of mitophagy / antibacterial innate immune response / positive regulation of B cell activation / positive regulation of xenophagy / xenophagy / positive regulation of protein K63-linked ubiquitination / cellular response to muramyl dipeptide / positive regulation of stress-activated MAPK cascade / positive regulation of type 2 immune response / CARD domain binding / cellular response to peptidoglycan / peptidoglycan binding / negative regulation of interleukin-12 production / nucleotide-binding oligomerization domain containing 2 signaling pathway / positive regulation of cytokine production involved in inflammatory response / positive regulation of monocyte chemotactic protein-1 production / positive regulation of macrophage cytokine production / extrinsic component of plasma membrane / negative regulation of interleukin-2 production / temperature homeostasis / pattern recognition receptor activity / positive regulation of Notch signaling pathway / response to exogenous dsRNA / positive regulation of interleukin-17 production / response to muramyl dipeptide / negative regulation of type II interferon production / positive regulation of interleukin-10 production / negative regulation of tumor necrosis factor production / phagocytosis / detection of bacterium / stress-activated MAPK cascade / phagocytic vesicle / positive regulation of phagocytosis / JNK cascade / ERK1 and ERK2 cascade / positive regulation of interleukin-12 production / Hsp70 protein binding / response to endoplasmic reticulum stress / positive regulation of epithelial cell proliferation / ubiquitin binding / positive regulation of interleukin-1 beta production / innate immune response in mucosa / positive regulation of interleukin-8 production / positive regulation of JNK cascade / negative regulation of inflammatory response to antigenic stimulus / Hsp90 protein binding / establishment of localization in cell / positive regulation of non-canonical NF-kappaB signal transduction / ADP binding / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / actin binding / cellular response to lipopolysaccharide / basolateral plasma membrane / adaptive immune response / cytoskeleton / positive regulation of canonical NF-kappaB signal transduction / positive regulation of ERK1 and ERK2 cascade / defense response to bacterium / protein-containing complex binding / protein kinase binding / cell surface / Golgi apparatus / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / ATP binding / cytosol 類似検索 - 分子機能
プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長
波長: 1 Å / 相対比: 1
反射
解像度: 3.3→50 Å / Num. obs: 35238 / % possible obs: 100 % / 冗長度: 6.1 % / Net I/σ(I): 8.4
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解析
ソフトウェア
名称
バージョン
分類
REFMAC
5.8.0103
精密化
HKL-2000
データ削減
HKL-2000
データスケーリング
MOLREP
位相決定
精密化
解像度: 3.31→50 Å / Cor.coef. Fo:Fc: 0.937 / Cor.coef. Fo:Fc free: 0.907 / SU B: 42.734 / SU ML: 0.323 / 交差検証法: THROUGHOUT / ESU R Free: 0.467 / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS