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- PDB-5ikn: Crystal Structure of the T7 Replisome in the Absence of DNA -

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Basic information

Entry
Database: PDB / ID: 5ikn
TitleCrystal Structure of the T7 Replisome in the Absence of DNA
Components
  • DNA primase/helicase
  • DNA-directed DNA polymerase
  • Thioredoxin-1
KeywordsTRANSFERASE / Replisome
Function / homology
Function and homology information


DNA synthesis involved in DNA replication / DNA exonuclease activity / DNA replication, synthesis of primer / viral DNA genome replication / Hydrolases; Acting on ester bonds; Exodeoxyribonucleases producing 5'-phosphomonoesters / protein-disulfide reductase activity / 3'-5' exonuclease activity / DNA helicase activity / cell redox homeostasis / DNA-templated DNA replication ...DNA synthesis involved in DNA replication / DNA exonuclease activity / DNA replication, synthesis of primer / viral DNA genome replication / Hydrolases; Acting on ester bonds; Exodeoxyribonucleases producing 5'-phosphomonoesters / protein-disulfide reductase activity / 3'-5' exonuclease activity / DNA helicase activity / cell redox homeostasis / DNA-templated DNA replication / Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases / DNA-directed RNA polymerase activity / double-strand break repair / single-stranded DNA binding / 5'-3' DNA helicase activity / DNA helicase / DNA-directed DNA polymerase / DNA-directed DNA polymerase activity / nucleotide binding / ATP hydrolysis activity / DNA binding / zinc ion binding / ATP binding / metal ion binding / identical protein binding / cytosol
Similarity search - Function
Bacteriophage T7 DNA helicase/primase / : / Bacteriophage T7 DNA helicase/primase, N-terminal a+b fold / Bacteriophage T7, Gp4, DNA primase/helicase, N-terminal / Zinc-binding domain of primase-helicase / Zinc-binding domain of primase-helicase / DNA-directed DNA polymerase T7 / Twinkle-like protein / Archaeal primase DnaG/twinkle-like, TOPRIM domain / Toprim-like ...Bacteriophage T7 DNA helicase/primase / : / Bacteriophage T7 DNA helicase/primase, N-terminal a+b fold / Bacteriophage T7, Gp4, DNA primase/helicase, N-terminal / Zinc-binding domain of primase-helicase / Zinc-binding domain of primase-helicase / DNA-directed DNA polymerase T7 / Twinkle-like protein / Archaeal primase DnaG/twinkle-like, TOPRIM domain / Toprim-like / DnaB-like helicase C terminal domain / DNA helicase, DnaB-like, C-terminal / Superfamily 4 helicase domain profile. / TOPRIM / Thioredoxin / DNA polymerase A / DNA polymerase family A / DNA-directed DNA polymerase, family A, conserved site / DNA polymerase family A signature. / DNA-directed DNA polymerase, family A, palm domain / DNA polymerase A domain / Toprim domain profile. / TOPRIM domain / Thioredoxin / Thioredoxin, conserved site / Thioredoxin family active site. / Thioredoxin domain profile. / Thioredoxin domain / Thioredoxin-like superfamily / Ribonuclease H superfamily / Ribonuclease H-like superfamily / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase
Similarity search - Domain/homology
DNA-directed DNA polymerase / DNA helicase/primase / Thioredoxin 1
Similarity search - Component
Biological speciesEnterobacteria phage T7 (virus)
Escherichia coli O157:H7 (bacteria)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 4.802 Å
AuthorsWallen, J.R. / Ellenberger, T.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM055390 United States
CitationJournal: Structure / Year: 2017
Title: Hybrid Methods Reveal Multiple Flexibly Linked DNA Polymerases within the Bacteriophage T7 Replisome.
Authors: Wallen, J.R. / Zhang, H. / Weis, C. / Cui, W. / Foster, B.M. / Ho, C.M. / Hammel, M. / Tainer, J.A. / Gross, M.L. / Ellenberger, T.
History
DepositionMar 3, 2016Deposition site: RCSB / Processing site: RCSB
Revision 1.0Dec 7, 2016Provider: repository / Type: Initial release
Revision 1.1Jan 18, 2017Group: Database references
Revision 1.2Sep 20, 2017Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
Revision 1.3Dec 25, 2019Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
Revision 1.4Sep 27, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: DNA-directed DNA polymerase
B: DNA-directed DNA polymerase
C: DNA-directed DNA polymerase
D: DNA primase/helicase
E: DNA primase/helicase
F: DNA primase/helicase
G: DNA primase/helicase
H: DNA primase/helicase
I: DNA primase/helicase
J: DNA primase/helicase
K: Thioredoxin-1
L: Thioredoxin-1
M: Thioredoxin-1


Theoretical massNumber of molelcules
Total (without water)650,05813
Polymers650,05813
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area35930 Å2
ΔGint-86 kcal/mol
Surface area239180 Å2
Unit cell
Length a, b, c (Å)174.866, 238.091, 243.466
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number19
Space group name H-MP212121
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
11(chain K and (resseq 3:7 or resseq 9:18 or resseq...
21(chain L and (resseq 3:7 or resseq 9:18 or resseq...
31(chain M and (resseq 3:7 or resseq 9:18 or resseq...
12(chain A and (resseq 202:261 or resseq 339:349 or resseq...
22(chain B and (resseq 202:261 or resseq 339:349 or resseq...
32(chain C and (resseq 202:261 or resseq 339:349 or resseq...
13(chain D and (resseq 272:281 or resseq 294:300 or resseq...
23(chain E and (resseq 272:281 or resseq 294:300 or resseq...
33(chain F and (resseq 272:281 or resseq 294:300 or resseq...
43(chain G and (resseq 272:281 or resseq 294:300 or resseq...
53(chain H and (resseq 272:281 or resseq 294:300 or resseq...
63(chain I and (resseq 272:281 or resseq 294:300 or resseq...
73(chain J and (resseq 272:281 or resseq 294:300 or resseq...
14(chain D and (resseq 74:78 or resseq 80:82 or resseq...
24(chain E and (resseq 74:78 or resseq 80:82 or resseq...
34(chain F and (resseq 74:78 or resseq 80:82 or resseq...
44(chain G and (resseq 74:78 or resseq 80:82 or resseq...
54(chain H and (resseq 74:78 or resseq 80:82 or resseq...
64(chain I and (resseq 74:78 or resseq 80:82 or resseq...
74(chain J and (resseq 74:78 or resseq 80:82 or resseq...
15(chain A and (resseq 447:454 or resseq 470:477 or resseq...
25(chain B and (resseq 447:454 or resseq 470:477 or resseq...
35(chain C and (resseq 447:454 or resseq 470:477 or resseq...
16(chain A and (resseq 1:9 or resseq 17:26 or resseq...
26(chain B and (resseq 1:9 or resseq 17:26 or resseq...
36(chain C and (resseq 1:9 or resseq 17:26 or resseq...
17(chain A and (resseq 478:514 or resseq 517:530 or resseq...
27(chain B and (resseq 478:514 or resseq 517:530 or resseq...
37(chain C and (resseq 478:514 or resseq 517:530 or resseq...

NCS domain segments:
Dom-IDComponent-IDEns-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
111LYSLYSLEULEU(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK3 - 71 - 5
121ASPASPLYSLYS(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK9 - 187 - 16
131ALAALAALAALA(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK22 - 2920 - 27
141GLYGLYGLUGLU(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK33 - 4831 - 46
151THRTHRILEILE(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK54 - 6052 - 58
161PROPROLYSLYS(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK64 - 6962 - 67
171PROPROASNASN(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK76 - 8374 - 81
181GLUGLUGLYGLY(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK85 - 9283 - 90
191LYSLYSLEULEU(chain K and (resseq 3:7 or resseq 9:18 or resseq...KK96 - 10794 - 105
211LYSLYSLEULEU(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL3 - 71 - 5
221ASPASPLYSLYS(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL9 - 187 - 16
231ALAALAALAALA(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL22 - 2920 - 27
241GLYGLYGLUGLU(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL33 - 4831 - 46
251THRTHRILEILE(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL54 - 6052 - 58
261PROPROLYSLYS(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL64 - 6962 - 67
271PROPROASNASN(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL76 - 8374 - 81
281GLUGLUGLYGLY(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL85 - 9283 - 90
291LYSLYSLEULEU(chain L and (resseq 3:7 or resseq 9:18 or resseq...LL96 - 10794 - 105
311LYSLYSLEULEU(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM3 - 71 - 5
321ASPASPLYSLYS(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM9 - 187 - 16
331ALAALAALAALA(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM22 - 2920 - 27
341GLYGLYGLUGLU(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM33 - 4831 - 46
351THRTHRILEILE(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM54 - 6052 - 58
361PROPROLYSLYS(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM64 - 6962 - 67
371PROPROASNASN(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM76 - 8374 - 81
381GLUGLUGLYGLY(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM85 - 9283 - 90
391LYSLYSLEULEU(chain M and (resseq 3:7 or resseq 9:18 or resseq...MM96 - 10794 - 105
112GLYGLYPHEPHE(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA202 - 261202 - 261
122ARGARGALAALA(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA339 - 349339 - 349
132LYSLYSTHRTHR(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA355 - 357355 - 357
142ALAALAVALVAL(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA361 - 363361 - 363
152ASPASPVALVAL(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA365 - 372365 - 372
162ASPASPALAALA(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA376 - 400376 - 400
172ALAALAVALVAL(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA405 - 410405 - 410
182GLYGLYASNASN(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA414 - 421414 - 421
192ALAALAALAALA(chain A and (resseq 202:261 or resseq 339:349 or resseq...AA430 - 433430 - 433
212GLYGLYPHEPHE(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB202 - 261202 - 261
222ARGARGALAALA(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB339 - 349339 - 349
232LYSLYSTHRTHR(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB355 - 357355 - 357
242ALAALAVALVAL(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB361 - 363361 - 363
252ASPASPVALVAL(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB365 - 372365 - 372
262ASPASPALAALA(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB376 - 400376 - 400
272ALAALAVALVAL(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB405 - 410405 - 410
282GLYGLYASNASN(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB414 - 421414 - 421
292ALAALAALAALA(chain B and (resseq 202:261 or resseq 339:349 or resseq...BB430 - 433430 - 433
312GLYGLYPHEPHE(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC202 - 261202 - 261
322ARGARGALAALA(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC339 - 349339 - 349
332LYSLYSTHRTHR(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC355 - 357355 - 357
342ALAALAVALVAL(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC361 - 363361 - 363
352ASPASPVALVAL(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC365 - 372365 - 372
362ASPASPALAALA(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC376 - 400376 - 400
372ALAALAVALVAL(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC405 - 410405 - 410
382GLYGLYASNASN(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC414 - 421414 - 421
392ALAALAALAALA(chain C and (resseq 202:261 or resseq 339:349 or resseq...CC430 - 433430 - 433
113ARGARGSERSER(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD272 - 281209 - 218
123GLYGLYLEULEU(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD294 - 300231 - 237
133VALVALSERSER(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD307 - 312244 - 249
143LYSLYSGLYGLY(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD318 - 334255 - 271
153LYSLYSMETMET(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD336 - 341273 - 278
163VALVALASNASN(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD346 - 358283 - 295
173ASPASPGLUGLU(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD366 - 374303 - 311
183PHEPHEGLYGLY(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD378 - 387315 - 324
193PHEPHETYRTYR(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD391 - 394328 - 331
1103THRTHRGLYGLY(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD402 - 417339 - 354
1113VALVALILEILE(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD420 - 426357 - 363
1123GLUGLUGLYGLY(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD438 - 457375 - 394
1133VALVALCYSCYS(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD459 - 464396 - 401
1143ILEILELEULEU(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD483 - 486420 - 423
1153GLYGLYLEULEU(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD490 - 495427 - 432
1163THRTHRARGARG(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD498 - 504435 - 441
1173LEULEUCYSCYS(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD513 - 521450 - 458
1183GLYGLYASNASN(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD525 - 536462 - 473
1193TRPTRPTRPTRP(chain D and (resseq 272:281 or resseq 294:300 or resseq...DD541478
213ARGARGSERSER(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE272 - 281209 - 218
223GLYGLYLEULEU(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE294 - 300231 - 237
233VALVALSERSER(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE307 - 312244 - 249
243LYSLYSGLYGLY(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE318 - 334255 - 271
253LYSLYSMETMET(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE336 - 341273 - 278
263VALVALASNASN(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE346 - 358283 - 295
273ASPASPGLUGLU(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE366 - 374303 - 311
283PHEPHEGLYGLY(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE378 - 387315 - 324
293PHEPHETYRTYR(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE391 - 394328 - 331
2103THRTHRGLYGLY(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE402 - 417339 - 354
2113VALVALILEILE(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE420 - 426357 - 363
2123GLUGLUGLYGLY(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE438 - 457375 - 394
2133VALVALCYSCYS(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE459 - 464396 - 401
2143ILEILELEULEU(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE483 - 486420 - 423
2153GLYGLYLEULEU(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE490 - 495427 - 432
2163THRTHRARGARG(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE498 - 504435 - 441
2173LEULEUCYSCYS(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE513 - 521450 - 458
2183GLYGLYASNASN(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE525 - 536462 - 473
2193TRPTRPTRPTRP(chain E and (resseq 272:281 or resseq 294:300 or resseq...EE541478
313ARGARGSERSER(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF272 - 281209 - 218
323GLYGLYLEULEU(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF294 - 300231 - 237
333VALVALSERSER(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF307 - 312244 - 249
343LYSLYSGLYGLY(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF318 - 334255 - 271
353LYSLYSMETMET(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF336 - 341273 - 278
363VALVALASNASN(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF346 - 358283 - 295
373ASPASPGLUGLU(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF366 - 374303 - 311
383PHEPHEGLYGLY(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF378 - 387315 - 324
393PHEPHETYRTYR(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF391 - 394328 - 331
3103THRTHRGLYGLY(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF402 - 417339 - 354
3113VALVALILEILE(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF420 - 426357 - 363
3123GLUGLUGLYGLY(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF438 - 457375 - 394
3133VALVALCYSCYS(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF459 - 464396 - 401
3143ILEILELEULEU(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF483 - 486420 - 423
3153GLYGLYLEULEU(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF490 - 495427 - 432
3163THRTHRARGARG(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF498 - 504435 - 441
3173LEULEUCYSCYS(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF513 - 521450 - 458
3183GLYGLYASNASN(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF525 - 536462 - 473
3193TRPTRPTRPTRP(chain F and (resseq 272:281 or resseq 294:300 or resseq...FF541478
413ARGARGSERSER(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG272 - 281209 - 218
423GLYGLYLEULEU(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG294 - 300231 - 237
433VALVALSERSER(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG307 - 312244 - 249
443LYSLYSGLYGLY(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG318 - 334255 - 271
453LYSLYSMETMET(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG336 - 341273 - 278
463VALVALASNASN(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG346 - 358283 - 295
473ASPASPGLUGLU(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG366 - 374303 - 311
483PHEPHEGLYGLY(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG378 - 387315 - 324
493PHEPHETYRTYR(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG391 - 394328 - 331
4103THRTHRGLYGLY(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG402 - 417339 - 354
4113VALVALILEILE(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG420 - 426357 - 363
4123GLUGLUGLYGLY(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG438 - 457375 - 394
4133VALVALCYSCYS(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG459 - 464396 - 401
4143ILEILELEULEU(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG483 - 486420 - 423
4153GLYGLYLEULEU(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG490 - 495427 - 432
4163THRTHRARGARG(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG498 - 504435 - 441
4173LEULEUCYSCYS(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG513 - 521450 - 458
4183GLYGLYASNASN(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG525 - 536462 - 473
4193TRPTRPTRPTRP(chain G and (resseq 272:281 or resseq 294:300 or resseq...GG541478
513ARGARGSERSER(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH272 - 281209 - 218
523GLYGLYLEULEU(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH294 - 300231 - 237
533VALVALSERSER(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH307 - 312244 - 249
543LYSLYSGLYGLY(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH318 - 334255 - 271
553LYSLYSMETMET(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH336 - 341273 - 278
563VALVALASNASN(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH346 - 358283 - 295
573ASPASPGLUGLU(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH366 - 374303 - 311
583PHEPHEGLYGLY(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH378 - 387315 - 324
593PHEPHETYRTYR(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH391 - 394328 - 331
5103THRTHRGLYGLY(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH402 - 417339 - 354
5113VALVALILEILE(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH420 - 426357 - 363
5123GLUGLUGLYGLY(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH438 - 457375 - 394
5133VALVALCYSCYS(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH459 - 464396 - 401
5143ILEILELEULEU(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH483 - 486420 - 423
5153GLYGLYLEULEU(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH490 - 495427 - 432
5163THRTHRARGARG(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH498 - 504435 - 441
5173LEULEUCYSCYS(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH513 - 521450 - 458
5183GLYGLYASNASN(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH525 - 536462 - 473
5193TRPTRPTRPTRP(chain H and (resseq 272:281 or resseq 294:300 or resseq...HH541478
613ARGARGSERSER(chain I and (resseq 272:281 or resseq 294:300 or resseq...II272 - 281209 - 218
623GLYGLYLEULEU(chain I and (resseq 272:281 or resseq 294:300 or resseq...II294 - 300231 - 237
633VALVALSERSER(chain I and (resseq 272:281 or resseq 294:300 or resseq...II307 - 312244 - 249
643LYSLYSGLYGLY(chain I and (resseq 272:281 or resseq 294:300 or resseq...II318 - 334255 - 271
653LYSLYSMETMET(chain I and (resseq 272:281 or resseq 294:300 or resseq...II336 - 341273 - 278
663VALVALASNASN(chain I and (resseq 272:281 or resseq 294:300 or resseq...II346 - 358283 - 295
673ASPASPGLUGLU(chain I and (resseq 272:281 or resseq 294:300 or resseq...II366 - 374303 - 311
683PHEPHEGLYGLY(chain I and (resseq 272:281 or resseq 294:300 or resseq...II378 - 387315 - 324
693PHEPHETYRTYR(chain I and (resseq 272:281 or resseq 294:300 or resseq...II391 - 394328 - 331
6103THRTHRGLYGLY(chain I and (resseq 272:281 or resseq 294:300 or resseq...II402 - 417339 - 354
6113VALVALILEILE(chain I and (resseq 272:281 or resseq 294:300 or resseq...II420 - 426357 - 363
6123GLUGLUGLYGLY(chain I and (resseq 272:281 or resseq 294:300 or resseq...II438 - 457375 - 394
6133VALVALCYSCYS(chain I and (resseq 272:281 or resseq 294:300 or resseq...II459 - 464396 - 401
6143ILEILELEULEU(chain I and (resseq 272:281 or resseq 294:300 or resseq...II483 - 486420 - 423
6153GLYGLYLEULEU(chain I and (resseq 272:281 or resseq 294:300 or resseq...II490 - 495427 - 432
6163THRTHRARGARG(chain I and (resseq 272:281 or resseq 294:300 or resseq...II498 - 504435 - 441
6173LEULEUCYSCYS(chain I and (resseq 272:281 or resseq 294:300 or resseq...II513 - 521450 - 458
6183GLYGLYASNASN(chain I and (resseq 272:281 or resseq 294:300 or resseq...II525 - 536462 - 473
6193TRPTRPTRPTRP(chain I and (resseq 272:281 or resseq 294:300 or resseq...II541478
713ARGARGSERSER(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ272 - 281209 - 218
723GLYGLYLEULEU(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ294 - 300231 - 237
733VALVALSERSER(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ307 - 312244 - 249
743LYSLYSGLYGLY(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ318 - 334255 - 271
753LYSLYSMETMET(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ336 - 341273 - 278
763VALVALASNASN(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ346 - 358283 - 295
773ASPASPGLUGLU(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ366 - 374303 - 311
783PHEPHEGLYGLY(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ378 - 387315 - 324
793PHEPHETYRTYR(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ391 - 394328 - 331
7103THRTHRGLYGLY(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ402 - 417339 - 354
7113VALVALILEILE(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ420 - 426357 - 363
7123GLUGLUGLYGLY(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ438 - 457375 - 394
7133VALVALCYSCYS(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ459 - 464396 - 401
7143ILEILELEULEU(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ483 - 486420 - 423
7153GLYGLYLEULEU(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ490 - 495427 - 432
7163THRTHRARGARG(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ498 - 504435 - 441
7173LEULEUCYSCYS(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ513 - 521450 - 458
7183GLYGLYASNASN(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ525 - 536462 - 473
7193TRPTRPTRPTRP(chain J and (resseq 272:281 or resseq 294:300 or resseq...JJ541478
114SERSERTYRTYR(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD74 - 7811 - 15
124ALAALATHRTHR(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD80 - 8217 - 19
134ILEILEVALVAL(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD86 - 10123 - 38
144METMETASPASP(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD105 - 11342 - 50
154GLYGLYASPASP(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD116 - 12553 - 62
164LYSLYSSERSER(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD128 - 13565 - 72
174ALAALATRPTRP(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD140 - 14777 - 84
184LYSLYSTHRTHR(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD152 - 15689 - 93
194GLUGLULYSLYS(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD159 - 17296 - 109
1104VALVALGLYGLY(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD175 - 179112 - 116
1114SERSERGLNGLN(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD183 - 198120 - 135
1124GLNGLNMETMET(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD201 - 205138 - 142
1134GLUGLULEULEU(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD210 - 223147 - 160
1144LYSLYSALAALA(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD227 - 231164 - 168
1154ALAALAASNASN(chain D and (resseq 74:78 or resseq 80:82 or resseq...DD238 - 256175 - 193
214SERSERTYRTYR(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE74 - 7811 - 15
224ALAALATHRTHR(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE80 - 8217 - 19
234ILEILEVALVAL(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE86 - 10123 - 38
244METMETASPASP(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE105 - 11342 - 50
254GLYGLYASPASP(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE116 - 12553 - 62
264LYSLYSSERSER(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE128 - 13565 - 72
274ALAALATRPTRP(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE140 - 14777 - 84
284LYSLYSTHRTHR(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE152 - 15689 - 93
294GLUGLULYSLYS(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE159 - 17296 - 109
2104VALVALGLYGLY(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE175 - 179112 - 116
2114SERSERGLNGLN(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE183 - 198120 - 135
2124GLNGLNMETMET(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE201 - 205138 - 142
2134GLUGLULEULEU(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE210 - 223147 - 160
2144LYSLYSALAALA(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE227 - 231164 - 168
2154ALAALAASNASN(chain E and (resseq 74:78 or resseq 80:82 or resseq...EE238 - 256175 - 193
314SERSERTYRTYR(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF74 - 7811 - 15
324ALAALATHRTHR(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF80 - 8217 - 19
334ILEILEVALVAL(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF86 - 10123 - 38
344METMETASPASP(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF105 - 11342 - 50
354GLYGLYASPASP(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF116 - 12553 - 62
364LYSLYSSERSER(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF128 - 13565 - 72
374ALAALATRPTRP(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF140 - 14777 - 84
384LYSLYSTHRTHR(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF152 - 15689 - 93
394GLUGLULYSLYS(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF159 - 17296 - 109
3104VALVALGLYGLY(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF175 - 179112 - 116
3114SERSERGLNGLN(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF183 - 198120 - 135
3124GLNGLNMETMET(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF201 - 205138 - 142
3134GLUGLULEULEU(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF210 - 223147 - 160
3144LYSLYSALAALA(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF227 - 231164 - 168
3154ALAALAASNASN(chain F and (resseq 74:78 or resseq 80:82 or resseq...FF238 - 256175 - 193
414SERSERTYRTYR(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG74 - 7811 - 15
424ALAALATHRTHR(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG80 - 8217 - 19
434ILEILEVALVAL(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG86 - 10123 - 38
444METMETASPASP(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG105 - 11342 - 50
454GLYGLYASPASP(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG116 - 12553 - 62
464LYSLYSSERSER(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG128 - 13565 - 72
474ALAALATRPTRP(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG140 - 14777 - 84
484LYSLYSTHRTHR(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG152 - 15689 - 93
494GLUGLULYSLYS(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG159 - 17296 - 109
4104VALVALGLYGLY(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG175 - 179112 - 116
4114SERSERGLNGLN(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG183 - 198120 - 135
4124GLNGLNMETMET(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG201 - 205138 - 142
4134GLUGLULEULEU(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG210 - 223147 - 160
4144LYSLYSALAALA(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG227 - 231164 - 168
4154ALAALAASNASN(chain G and (resseq 74:78 or resseq 80:82 or resseq...GG238 - 256175 - 193
514SERSERTYRTYR(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH74 - 7811 - 15
524ALAALATHRTHR(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH80 - 8217 - 19
534ILEILEVALVAL(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH86 - 10123 - 38
544METMETASPASP(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH105 - 11342 - 50
554GLYGLYASPASP(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH116 - 12553 - 62
564LYSLYSSERSER(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH128 - 13565 - 72
574ALAALATRPTRP(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH140 - 14777 - 84
584LYSLYSTHRTHR(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH152 - 15689 - 93
594GLUGLULYSLYS(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH159 - 17296 - 109
5104VALVALGLYGLY(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH175 - 179112 - 116
5114SERSERGLNGLN(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH183 - 198120 - 135
5124GLNGLNMETMET(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH201 - 205138 - 142
5134GLUGLULEULEU(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH210 - 223147 - 160
5144LYSLYSALAALA(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH227 - 231164 - 168
5154ALAALAASNASN(chain H and (resseq 74:78 or resseq 80:82 or resseq...HH238 - 256175 - 193
614SERSERTYRTYR(chain I and (resseq 74:78 or resseq 80:82 or resseq...II74 - 7811 - 15
624ALAALATHRTHR(chain I and (resseq 74:78 or resseq 80:82 or resseq...II80 - 8217 - 19
634ILEILEVALVAL(chain I and (resseq 74:78 or resseq 80:82 or resseq...II86 - 10123 - 38
644METMETASPASP(chain I and (resseq 74:78 or resseq 80:82 or resseq...II105 - 11342 - 50
654GLYGLYASPASP(chain I and (resseq 74:78 or resseq 80:82 or resseq...II116 - 12553 - 62
664LYSLYSSERSER(chain I and (resseq 74:78 or resseq 80:82 or resseq...II128 - 13565 - 72
674ALAALATRPTRP(chain I and (resseq 74:78 or resseq 80:82 or resseq...II140 - 14777 - 84
684LYSLYSTHRTHR(chain I and (resseq 74:78 or resseq 80:82 or resseq...II152 - 15689 - 93
694GLUGLULYSLYS(chain I and (resseq 74:78 or resseq 80:82 or resseq...II159 - 17296 - 109
6104VALVALGLYGLY(chain I and (resseq 74:78 or resseq 80:82 or resseq...II175 - 179112 - 116
6114SERSERGLNGLN(chain I and (resseq 74:78 or resseq 80:82 or resseq...II183 - 198120 - 135
6124GLNGLNMETMET(chain I and (resseq 74:78 or resseq 80:82 or resseq...II201 - 205138 - 142
6134GLUGLULEULEU(chain I and (resseq 74:78 or resseq 80:82 or resseq...II210 - 223147 - 160
6144LYSLYSALAALA(chain I and (resseq 74:78 or resseq 80:82 or resseq...II227 - 231164 - 168
6154ALAALAASNASN(chain I and (resseq 74:78 or resseq 80:82 or resseq...II238 - 256175 - 193
714SERSERTYRTYR(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ74 - 7811 - 15
724ALAALATHRTHR(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ80 - 8217 - 19
734ILEILEVALVAL(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ86 - 10123 - 38
744METMETASPASP(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ105 - 11342 - 50
754GLYGLYASPASP(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ116 - 12553 - 62
764LYSLYSSERSER(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ128 - 13565 - 72
774ALAALATRPTRP(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ140 - 14777 - 84
784LYSLYSTHRTHR(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ152 - 15689 - 93
794GLUGLULYSLYS(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ159 - 17296 - 109
7104VALVALGLYGLY(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ175 - 179112 - 116
7114SERSERGLNGLN(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ183 - 198120 - 135
7124GLNGLNMETMET(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ201 - 205138 - 142
7134GLUGLULEULEU(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ210 - 223147 - 160
7144LYSLYSALAALA(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ227 - 231164 - 168
7154ALAALAASNASN(chain J and (resseq 74:78 or resseq 80:82 or resseq...JJ238 - 256175 - 193
115TYRTYRALAALA(chain A and (resseq 447:454 or resseq 470:477 or resseq...AA447 - 454447 - 454
125VALVALSERSER(chain A and (resseq 447:454 or resseq 470:477 or resseq...AA470 - 477470 - 477
135ASPASPVALVAL(chain A and (resseq 447:454 or resseq 470:477 or resseq...AA645 - 652645 - 652
145ASPASPASNASN(chain A and (resseq 447:454 or resseq 470:477 or resseq...AA654 - 685654 - 685
155ASPASPPROPRO(chain A and (resseq 447:454 or resseq 470:477 or resseq...AA691 - 698691 - 698
215TYRTYRALAALA(chain B and (resseq 447:454 or resseq 470:477 or resseq...BB447 - 454447 - 454
225VALVALSERSER(chain B and (resseq 447:454 or resseq 470:477 or resseq...BB470 - 477470 - 477
235ASPASPVALVAL(chain B and (resseq 447:454 or resseq 470:477 or resseq...BB645 - 652645 - 652
245ASPASPASNASN(chain B and (resseq 447:454 or resseq 470:477 or resseq...BB654 - 685654 - 685
255ASPASPPROPRO(chain B and (resseq 447:454 or resseq 470:477 or resseq...BB691 - 698691 - 698
315TYRTYRALAALA(chain C and (resseq 447:454 or resseq 470:477 or resseq...CC447 - 454447 - 454
325VALVALSERSER(chain C and (resseq 447:454 or resseq 470:477 or resseq...CC470 - 477470 - 477
335ASPASPVALVAL(chain C and (resseq 447:454 or resseq 470:477 or resseq...CC645 - 652645 - 652
345ASPASPASNASN(chain C and (resseq 447:454 or resseq 470:477 or resseq...CC654 - 685654 - 685
355ASPASPPROPRO(chain C and (resseq 447:454 or resseq 470:477 or resseq...CC691 - 698691 - 698
116METMETASNASN(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA1 - 91 - 9
126LYSLYSTYRTYR(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA17 - 2617 - 26
136GLUGLUTYRTYR(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA30 - 3430 - 34
146ASPASPARGARG(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA38 - 5238 - 52
156LEULEUHISHIS(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA55 - 5955 - 59
166TYRTYRLEULEU(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA64 - 7764 - 77
176ASNASNHISHIS(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA87 - 9987 - 99
186LYSLYSSERSER(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA103 - 112103 - 112
196LEULEUARGARG(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA125 - 131125 - 131
1106LYSLYSGLUGLU(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA140 - 149140 - 149
1116ASNASNSERSER(chain A and (resseq 1:9 or resseq 17:26 or resseq...AA164 - 187164 - 187
216METMETASNASN(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB1 - 91 - 9
226LYSLYSTYRTYR(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB17 - 2617 - 26
236GLUGLUTYRTYR(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB30 - 3430 - 34
246ASPASPARGARG(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB38 - 5238 - 52
256LEULEUHISHIS(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB55 - 5955 - 59
266TYRTYRLEULEU(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB64 - 7764 - 77
276ASNASNHISHIS(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB87 - 9987 - 99
286LYSLYSSERSER(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB103 - 112103 - 112
296LEULEUARGARG(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB125 - 131125 - 131
2106LYSLYSGLUGLU(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB140 - 149140 - 149
2116ASNASNSERSER(chain B and (resseq 1:9 or resseq 17:26 or resseq...BB164 - 187164 - 187
316METMETASNASN(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC1 - 91 - 9
326LYSLYSTYRTYR(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC17 - 2617 - 26
336GLUGLUTYRTYR(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC30 - 3430 - 34
346ASPASPARGARG(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC38 - 5238 - 52
356LEULEUHISHIS(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC55 - 5955 - 59
366TYRTYRLEULEU(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC64 - 7764 - 77
376ASNASNHISHIS(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC87 - 9987 - 99
386LYSLYSSERSER(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC103 - 112103 - 112
396LEULEUARGARG(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC125 - 131125 - 131
3106LYSLYSGLUGLU(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC140 - 149140 - 149
3116ASNASNSERSER(chain C and (resseq 1:9 or resseq 17:26 or resseq...CC164 - 187164 - 187
117GLYGLYGLUGLU(chain A and (resseq 478:514 or resseq 517:530 or resseq...AA478 - 514478 - 514
127THRTHRTYRTYR(chain A and (resseq 478:514 or resseq 517:530 or resseq...AA517 - 530517 - 530
137GLYGLYGLYGLY(chain A and (resseq 478:514 or resseq 517:530 or resseq...AA533 - 542533 - 542
147GLYGLYVALVAL(chain A and (resseq 478:514 or resseq 517:530 or resseq...AA544 - 580544 - 580
157GLUGLULYSLYS(chain A and (resseq 478:514 or resseq 517:530 or resseq...AA583 - 589583 - 589
167ARGARGGLYGLY(chain A and (resseq 478:514 or resseq 517:530 or resseq...AA591 - 595591 - 595
177ARGARGVALVAL(chain A and (resseq 478:514 or resseq 517:530 or resseq...AA599 - 603599 - 603
187ALAALAGLUGLU(chain A and (resseq 478:514 or resseq 517:530 or resseq...AA608 - 635608 - 635
217GLYGLYGLUGLU(chain B and (resseq 478:514 or resseq 517:530 or resseq...BB478 - 514478 - 514
227THRTHRTYRTYR(chain B and (resseq 478:514 or resseq 517:530 or resseq...BB517 - 530517 - 530
237GLYGLYGLYGLY(chain B and (resseq 478:514 or resseq 517:530 or resseq...BB533 - 542533 - 542
247GLYGLYVALVAL(chain B and (resseq 478:514 or resseq 517:530 or resseq...BB544 - 580544 - 580
257GLUGLULYSLYS(chain B and (resseq 478:514 or resseq 517:530 or resseq...BB583 - 589583 - 589
267ARGARGGLYGLY(chain B and (resseq 478:514 or resseq 517:530 or resseq...BB591 - 595591 - 595
277ARGARGVALVAL(chain B and (resseq 478:514 or resseq 517:530 or resseq...BB599 - 603599 - 603
287ALAALAGLUGLU(chain B and (resseq 478:514 or resseq 517:530 or resseq...BB608 - 635608 - 635
317GLYGLYGLUGLU(chain C and (resseq 478:514 or resseq 517:530 or resseq...CC478 - 514478 - 514
327THRTHRTYRTYR(chain C and (resseq 478:514 or resseq 517:530 or resseq...CC517 - 530517 - 530
337GLYGLYGLYGLY(chain C and (resseq 478:514 or resseq 517:530 or resseq...CC533 - 542533 - 542
347GLYGLYVALVAL(chain C and (resseq 478:514 or resseq 517:530 or resseq...CC544 - 580544 - 580
357GLUGLULYSLYS(chain C and (resseq 478:514 or resseq 517:530 or resseq...CC583 - 589583 - 589
367ARGARGGLYGLY(chain C and (resseq 478:514 or resseq 517:530 or resseq...CC591 - 595591 - 595
377ARGARGVALVAL(chain C and (resseq 478:514 or resseq 517:530 or resseq...CC599 - 603599 - 603
387ALAALAGLUGLU(chain C and (resseq 478:514 or resseq 517:530 or resseq...CC608 - 635608 - 635

NCS ensembles :
ID
1
2
3
4
5
6
7

-
Components

#1: Protein DNA-directed DNA polymerase / DNA polymerase gp5 / Gene product 5 / Gp5 / T7 DNA polymerase


Mass: 79703.578 Da / Num. of mol.: 3 / Mutation: D5A, E7A
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Enterobacteria phage T7 (virus) / Production host: Escherichia coli (E. coli)
References: UniProt: P00581, DNA-directed DNA polymerase, Hydrolases; Acting on ester bonds; Exodeoxyribonucleases producing 5'-phosphomonoesters
#2: Protein
DNA primase/helicase / Gene product 4 / Gp4


Mass: 53815.004 Da / Num. of mol.: 7
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Enterobacteria phage T7 (virus) / Production host: Escherichia coli (E. coli)
References: UniProt: P03692, Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases, DNA helicase
#3: Protein Thioredoxin-1 / Trx-1


Mass: 11414.143 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Escherichia coli O157:H7 (bacteria) / Gene: trxA, Z5291, ECs4714 / Production host: Escherichia coli (E. coli) / References: UniProt: P0AA27

-
Experimental details

-
Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

-
Sample preparation

CrystalDensity Matthews: 3.9 Å3/Da / Density % sol: 68.45 %
Crystal growTemperature: 295.15 K / Method: vapor diffusion, hanging drop / Details: 1.47-1.62M Sodium Formate 0.1M Tris pH 7.5

-
Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 21-ID-F / Wavelength: 0.97872 Å
DetectorType: MARMOSAIC 225 mm CCD / Detector: CCD / Date: Apr 25, 2011
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.97872 Å / Relative weight: 1
ReflectionResolution: 4.8→29.983 Å / Num. obs: 41183 / % possible obs: 97.9 % / Redundancy: 3.7 % / Net I/σ(I): 10.1
Reflection shellResolution: 4.8→4.88 Å / Redundancy: 3.3 % / % possible all: 97.6

-
Processing

Software
NameVersionClassification
PHENIX1.10_2155refinement
HKL-2000data scaling
PDB_EXTRACT3.2data extraction
HKL-2000data reduction
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 2AJQ, 1CR0, 1NUI

2ajq

1cr0

1nui


Resolution: 4.802→29.983 Å / SU ML: 0.9 / Cross valid method: FREE R-VALUE / σ(F): 1.37 / Phase error: 37.39 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.3178 2099 5.1 %
Rwork0.2747 39084 -
obs0.2768 41183 82.21 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso max: 466.39 Å2 / Biso mean: 240.1147 Å2 / Biso min: 130.89 Å2
Refinement stepCycle: final / Resolution: 4.802→29.983 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms43846 0 0 0 43846
Num. residues----5604
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00444683
X-RAY DIFFRACTIONf_angle_d0.73660276
X-RAY DIFFRACTIONf_chiral_restr0.0446554
X-RAY DIFFRACTIONf_plane_restr0.0047816
X-RAY DIFFRACTIONf_dihedral_angle_d14.67426680
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDNumberRefine-IDRmsType
11K1046X-RAY DIFFRACTION14.132TORSIONAL
12L1046X-RAY DIFFRACTION14.132TORSIONAL
13M1046X-RAY DIFFRACTION14.132TORSIONAL
21A1822X-RAY DIFFRACTION14.132TORSIONAL
22B1822X-RAY DIFFRACTION14.132TORSIONAL
23C1822X-RAY DIFFRACTION14.132TORSIONAL
31D5411X-RAY DIFFRACTION14.132TORSIONAL
32E5411X-RAY DIFFRACTION14.132TORSIONAL
33F5411X-RAY DIFFRACTION14.132TORSIONAL
34G5411X-RAY DIFFRACTION14.132TORSIONAL
35H5411X-RAY DIFFRACTION14.132TORSIONAL
36I5411X-RAY DIFFRACTION14.132TORSIONAL
37J5411X-RAY DIFFRACTION14.132TORSIONAL
41D4463X-RAY DIFFRACTION14.132TORSIONAL
42E4463X-RAY DIFFRACTION14.132TORSIONAL
43F4463X-RAY DIFFRACTION14.132TORSIONAL
44G4463X-RAY DIFFRACTION14.132TORSIONAL
45H4463X-RAY DIFFRACTION14.132TORSIONAL
46I4463X-RAY DIFFRACTION14.132TORSIONAL
47J4463X-RAY DIFFRACTION14.132TORSIONAL
51A859X-RAY DIFFRACTION14.132TORSIONAL
52B859X-RAY DIFFRACTION14.132TORSIONAL
53C859X-RAY DIFFRACTION14.132TORSIONAL
61A1677X-RAY DIFFRACTION14.132TORSIONAL
62B1677X-RAY DIFFRACTION14.132TORSIONAL
63C1677X-RAY DIFFRACTION14.132TORSIONAL
71A2033X-RAY DIFFRACTION14.132TORSIONAL
72B2033X-RAY DIFFRACTION14.132TORSIONAL
73C2033X-RAY DIFFRACTION14.132TORSIONAL
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Total num. of bins used: 15

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
4.8016-4.91290.4077470.353373978624
4.9129-5.03520.379720.35831307137942
5.0352-5.17060.3668950.33591745184056
5.1706-5.3220.34221160.35272097221367
5.322-5.49280.34991190.34762446256578
5.4928-5.68780.40121330.35422832296589
5.6878-5.91390.40211810.34193062324398
5.9139-6.18080.39071620.34523104326698
6.1808-6.50350.39691780.33433100327898
6.5035-6.90630.36661430.31963102324598
6.9063-7.4320.31031710.30263124329598
7.432-8.16620.31421960.27223100329698
8.1662-9.31670.28781540.22543125327997
9.3167-11.62320.2391700.19073139330997
11.6232-29.98310.29841620.24913062322491
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
15.54314.36922.798410.3227-1.18239.3630.3473-0.8556-0.41331.4115-0.49520.2858-0.16050.51760.22871.39310.12730.11051.62730.0731.3789-43.587-34.689141.875
27.8916-1.5333-0.28711.9240.30420.24930.528-0.6981-0.78960.1943-0.03141.07280.265-0.0461-0.55981.9511-0.19350.30451.44170.12931.4929-71.242-27.652122.662
34.13074.89241.57229.7611-0.40041.94-2.63214.0666-1.7998-4.9528-1.32940.5783-1.5399-2.20672.80233.6098-0.50010.03972.7289-0.57291.0414-70.802-20.185112.372
45.2227-0.98170.05734.78182.86420.88940.23130.8661-0.2754-0.5141-0.47320.1245-0.423-0.89680.07781.5137-0.16210.14572.15740.13081.2612-47.535-21.154110.35
58.01672.64082.48768.53444.95832.72410.25171.0691-0.62170.25240.12980.94990.45690.5207-0.38831.4930.16380.07091.76490.01911.1953-54.782-42.167105.182
64.7158-0.46671.13658.6083-0.96884.2492-0.0479-1.1473-0.02360.6739-0.20410.6490.1484-0.63020.32961.4463-0.05870.20161.4837-0.14481.153-79.559-10.12612.492
72.0937-0.09110.41713.22742.40877.8210.2360.9773-0.27630.2513-0.0664-0.11851.2355-0.2395-0.31861.3461-0.068-0.28882.01260.21381.4967-66.299-26.991-14.245
82.012.05816.57142.25422.07412.00152.52250.6398-4.5237-0.18355.0246-5.4017-2.6258-3.4567-6.02272.23720.72510.29962.18940.85392.7662-54.285-26.713-17.617
91.0114-0.63910.13586.8314-6.46779.0104-0.06980.4801-0.5032-0.7250.0017-0.40271.1145-0.48790.08051.3398-0.1557-0.2961.2062-0.14761.2572-47.179-17.9092.65
106.1564.39340.98257.15872.8263.2021-0.06720.3435-1.6021-0.3475-0.225-0.57380.0298-0.72820.37931.47240.247-0.08941.4368-0.13991.3145-53.851-39.0557.531
117.68953.78197.52391.36171.21895.8921-0.7879-0.48870.0658-0.0628-0.04381.2158-0.6498-0.76040.92131.53810.5120.03922.0093-0.26792.2561-24.297-79.3-0.353
123.48810.353-1.30680.58841.94298.2555-0.59230.26281.0717-0.30781.247-0.3197-0.32131.7145-0.51442.19130.0664-0.03381.7323-0.28952.2769-7.105-66.957-27.196
130.2329-0.2574-0.39090.22560.49611.2143-0.45213.4323-0.7944-0.5909-2.2104-1.2138-2.54251.95561.32353.1615-2.0582-0.45112.74510.41574.7824-7.939-55.723-32.279
141.31581.61461.39613.3353.56124.1574-0.9099-0.73382.2757-0.3405-0.0115-1.5125-4.8253-1.52910.74484.0970.6661-0.6961.966-0.49152.5817-18.061-47.541-13.021
156.5255-4.1588-0.65754.57060.68622.5484-0.26360.7741.1155-0.1847-0.2342-0.6982-1.57150.33470.48892.8356-0.0991-0.52981.89370.1571.88393.355-52.307-6.907
1611.6138-4.82780.77933.841.50194.2578-0.9072-1.0030.64210.19560.4946-0.0155-1.22230.08650.3851.98530.06070.10681.205-0.06211.3823-5.129-48.52294.775
174.7559-2.29031.22345.0052-1.5244.99740.01331.3727-0.6306-0.9576-0.1153-0.4130.33550.12750.14231.55790.0990.17631.8994-0.44391.5471-31-29.29983.605
181.832.1132.03975.13564.21527.69980.0618-0.2794-0.59390.08360.5921-0.69481.35030.8865-0.80771.98360.3872-0.3472.044-0.01141.5822-40.221-21.87652.387
195.91330.2422-0.1410.25151.17068.31230.6184-0.4883-0.2380.6275-0.5637-1.07540.39420.7432-0.02311.59780.1236-0.10761.28920.05741.2626-24.767-27.74624.609
200.1565-2.39010.737917.175-2.66785.19510.2267-0.3803-0.23090.083-0.49170.24820.25980.770.32421.3229-0.05940.15951.8189-0.28121.7465.939-39.00621.309
21-0.72840.8307-1.26476.4235-5.56474.48660.00550.61190.3712-0.40.60580.15440.4081-0.0678-0.54991.6256-0.21360.14212.2829-0.14872.190125.971-53.6645.229
224.82210.7035-1.49461.5998-1.19379.46450.21690.5621.23080.2531-0.23720.0881-1.81680.08840.01051.69180.0858-0.06261.18330.08171.834318.395-62.20375.223
23-0.55470.55590.76836.13141.26139.0349-0.2761-0.07580.66630.81030.0799-0.4238-0.29081.46430.33092.7265-0.2474-0.04222.5256-0.2462.632840.886-44.618109.772
248.9388-3.2754-2.41435.42111.68425.82570.04420.9768-1.0665-0.277-0.118-0.23010.6890.67420.0141.6049-0.0415-0.08681.6455-0.20541.466417.533-13.954116.713
251.2923-1.244-2.15488.58013.87196.20460.01420.9673-0.5344-0.9356-0.4138-1.61920.7641.5280.50821.62530.44590.49692.22240.1582.0045-7.25710.69483.063
262.4814-2.54211.16853.21394.91026.51290.2049-1.3251-1.37883.4239-0.5982-0.17511.93760.2410.5644.7119-0.5691-0.52782.18160.40632.6156-27.64418.97352.583
278.96062.9823-2.67147.1215-2.4789.8245-0.6623-1.12280.35060.64320.0937-0.73920.47331.50830.6471.530.2298-0.24861.3315-0.0271.7757-0.86812.37623.609
281.0828-1.71-3.36088.54570.60144.4425-0.2754-0.4308-0.6393-0.4546-0.47751.35060.4037-0.75530.72451.5044-0.12310.29311.8644-0.20892.654240.467-10.7712.921
291.1791-2.1035-4.67325.02832.06687.8747-0.6974-1.23760.58090.310.53880.2690.2268-0.20050.29411.6389-0.00430.08792.5966-0.54672.675866.72-33.44150.446
302.9967-1.3876-1.3674-0.08360.4496-0.9250.49251.61910.35021.9414-3.08023.51121.2627-2.09922.27373.2524-1.4790.4454.3047-0.32293.6863-116.239-36.258138.095
313.75250.2468-2.60595.56313.67971.7056-0.7351-1.52621.66720.2842-0.9581.0054-0.6837-0.30331.62912.3875-0.6661-0.59213.1245-0.33712.2727-90.978-41.836-53.61
324.8755-5.52910.4187.78482.27492.5264-1.82014.3342-1.33410.33560.8914-0.6264-0.16561.09850.88852.1585-0.67070.24983.9783-0.78522.830711.13-96.217-63.152
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND RESID 1:199 )A1 - 199
2X-RAY DIFFRACTION2( CHAIN A AND RESID 200:440 )A200 - 440
3X-RAY DIFFRACTION3( CHAIN A AND RESID 441:447 )A441 - 447
4X-RAY DIFFRACTION4( CHAIN A AND RESID 645:704 )A645 - 704
5X-RAY DIFFRACTION5( CHAIN A AND RESID 478:644 )A478 - 644
6X-RAY DIFFRACTION6( CHAIN B AND RESID 1:199 )B1 - 199
7X-RAY DIFFRACTION7( CHAIN B AND RESID 200:440 )B200 - 440
8X-RAY DIFFRACTION8( CHAIN B AND RESID 441:447 )B441 - 447
9X-RAY DIFFRACTION9( CHAIN B AND RESID 645:704 )B645 - 704
10X-RAY DIFFRACTION10( CHAIN B AND RESID 478:644 )B478 - 644
11X-RAY DIFFRACTION11( CHAIN C AND RESID 1:199 )C1 - 199
12X-RAY DIFFRACTION12( CHAIN C AND RESID 200:440 )C200 - 440
13X-RAY DIFFRACTION13( CHAIN C AND RESID 441:447 )C441 - 447
14X-RAY DIFFRACTION14( CHAIN C AND RESID 645:704 )C645 - 704
15X-RAY DIFFRACTION15( CHAIN C AND RESID 478:644 )C478 - 644
16X-RAY DIFFRACTION16( CHAIN D AND RESID 255:548 )D255 - 548
17X-RAY DIFFRACTION17( CHAIN E AND RESID 255:548 )E255 - 548
18X-RAY DIFFRACTION18( CHAIN F AND RESID 255:549 )F255 - 549
19X-RAY DIFFRACTION19( CHAIN G AND RESID 255:547 )G255 - 547
20X-RAY DIFFRACTION20( CHAIN H AND RESID 255:549 )H255 - 549
21X-RAY DIFFRACTION21( CHAIN I AND RESID 255:541 )I255 - 541
22X-RAY DIFFRACTION22( CHAIN J AND RESID 255:546 )J255 - 546
23X-RAY DIFFRACTION23( CHAIN D AND RESID 64:254 )D64 - 254
24X-RAY DIFFRACTION24( CHAIN E AND RESID 64:254 )E64 - 254
25X-RAY DIFFRACTION25( CHAIN F AND RESID 64:254 )F64 - 254
26X-RAY DIFFRACTION26( CHAIN G AND RESID 64:254 )G64 - 254
27X-RAY DIFFRACTION27( CHAIN H AND RESID 64:254 )H64 - 254
28X-RAY DIFFRACTION28( CHAIN I AND RESID 64:254 )I64 - 254
29X-RAY DIFFRACTION29( CHAIN J AND RESID 64:254 )J64 - 254
30X-RAY DIFFRACTION30( CHAIN K AND RESID 3:107 )K3 - 107
31X-RAY DIFFRACTION31( CHAIN L AND RESID 3:107 )L3 - 107
32X-RAY DIFFRACTION32( CHAIN M AND RESID 3:107 )M3 - 107

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