Entry | Database: PDB / ID: 5ht6 |
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Title | Crystal structure of the SET domain of the human MLL5 methyltransferase |
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Components | Histone-lysine N-methyltransferase 2E |
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Keywords | TRANSFERASE / SET domain |
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Function / homology | Function and homology information
Set3 complex / Rpd3L-Expanded complex / neutrophil activation / neutrophil mediated immunity / positive regulation of G1/S transition of mitotic cell cycle / epigenetic regulation of gene expression / methylated histone binding / erythrocyte differentiation / euchromatin / transcription coactivator activity ...Set3 complex / Rpd3L-Expanded complex / neutrophil activation / neutrophil mediated immunity / positive regulation of G1/S transition of mitotic cell cycle / epigenetic regulation of gene expression / methylated histone binding / erythrocyte differentiation / euchromatin / transcription coactivator activity / nuclear body / nuclear speck / cell cycle / centrosome / regulation of DNA-templated transcription / chromatin / positive regulation of DNA-templated transcription / enzyme binding / protein-containing complex / nucleoplasm / nucleus / metal ion binding / plasma membrane / cytoplasmSimilarity search - Function KMT2E, SET domain / PhD finger domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Zinc finger, PHD-type, conserved site / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. ...KMT2E, SET domain / PhD finger domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Zinc finger, PHD-type, conserved site / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger, FYVE/PHD-type / Zinc finger, RING/FYVE/PHD-typeSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.093 Å |
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Authors | le Maire, A. / Mas-y-Mas, S. / Dumas, C. / Lebedev, A. |
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Funding support | France, 1items Organization | Grant number | Country |
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Assocation pour la Recherche contre le Cancer | 075427 | France |
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Citation | Journal: Plos One / Year: 2016 Title: The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity. Authors: Mas-Y-Mas, S. / Barbon, M. / Teyssier, C. / Demene, H. / Carvalho, J.E. / Bird, L.E. / Lebedev, A. / Fattori, J. / Schubert, M. / Dumas, C. / Bourguet, W. / le Maire, A. |
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History | Deposition | Jan 26, 2016 | Deposition site: RCSB / Processing site: PDBE |
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Revision 1.0 | Nov 16, 2016 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 8, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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