Entry Database : PDB / ID : 5hbt Structure visualization Downloads & linksTitle Complex structure of Fab35 and human nAChR alpha1 ComponentsAcetylcholine receptor subunit alpha 1 Alpha-bungarotoxin isoform V31 Fab35, Heavy Chain Fab35, Light Chain DetailsKeywords TRANSPORT PROTEIN/TOXIN / nicotinic acetylcholine receptor alpha1 / Fab35 / Complex / Myasthenia Gravis / TRANSPORT PROTEIN-TOXIN complexFunction / homology Function and homology informationFunction Domain/homology Component
skeletal muscle tissue growth / musculoskeletal movement / Highly calcium permeable nicotinic acetylcholine receptors / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / neuromuscular synaptic transmission / acetylcholine-gated channel complex / acetylcholine receptor inhibitor activity / ion channel regulator activity / acetylcholine receptor activity / synaptic transmission, cholinergic ... skeletal muscle tissue growth / musculoskeletal movement / Highly calcium permeable nicotinic acetylcholine receptors / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / neuromuscular synaptic transmission / acetylcholine-gated channel complex / acetylcholine receptor inhibitor activity / ion channel regulator activity / acetylcholine receptor activity / synaptic transmission, cholinergic / acetylcholine binding / acetylcholine-gated monoatomic cation-selective channel activity / acetylcholine receptor signaling pathway / postsynaptic specialization membrane / neuromuscular process / neuromuscular junction development / muscle cell cellular homeostasis / skeletal muscle contraction / neuronal action potential / regulation of membrane potential / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / response to nicotine / neuromuscular junction / transmembrane signaling receptor activity / neuron cellular homeostasis / monoatomic ion channel activity / postsynaptic membrane / toxin activity / membrane => GO:0016020 / neuron projection / synapse / cell surface / signal transduction / extracellular region / plasma membrane Similarity search - Function Snake toxin and toxin-like protein / Snake three-finger toxin / Snake toxins signature. / Snake toxin, conserved site / Nicotinic acetylcholine receptor / CD59 / CD59 / Acetylcholine Binding Protein; Chain: A, / Neurotransmitter-gated ion-channel ligand-binding domain / Snake toxin-like superfamily ... Snake toxin and toxin-like protein / Snake three-finger toxin / Snake toxins signature. / Snake toxin, conserved site / Nicotinic acetylcholine receptor / CD59 / CD59 / Acetylcholine Binding Protein; Chain: A, / Neurotransmitter-gated ion-channel ligand-binding domain / Snake toxin-like superfamily / Neurotransmitter-gated ion-channel, conserved site / Neurotransmitter-gated ion-channels signature. / Neurotransmitter-gated ion-channel transmembrane domain / Neurotransmitter-gated ion-channel transmembrane region / Neurotransmitter-gated ion-channel transmembrane domain superfamily / Neuronal acetylcholine receptor / Neurotransmitter-gated ion-channel / Neurotransmitter-gated ion-channel ligand-binding domain / Neurotransmitter-gated ion-channel ligand-binding domain superfamily / Neurotransmitter-gated ion-channel ligand binding domain / Distorted Sandwich / Ribbon / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Rattus norvegicus (Norway rat)Bungarus multicinctus (many-banded krait)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.61 Å DetailsAuthors Noridomi, K. / Watanabe, G. / Hansen, M.N. / Han, G.W. / Chen, L. CitationJournal : Elife / Year : 2017Title : Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications.Authors : Noridomi, K. / Watanabe, G. / Hansen, M.N. / Han, G.W. / Chen, L. History Deposition Jan 2, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 3, 2017 Provider : repository / Type : Initial releaseRevision 1.1 May 10, 2017 Group : Database referencesRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _atom_site_anisotrop.U[1][1] / _atom_site_anisotrop.U[1][2] / _atom_site_anisotrop.U[1][3] / _atom_site_anisotrop.U[2][2] / _atom_site_anisotrop.U[2][3] / _atom_site_anisotrop.U[3][3] / _atom_site_anisotrop.pdbx_auth_asym_id / _atom_site_anisotrop.pdbx_auth_seq_id / _atom_site_anisotrop.pdbx_label_asym_id / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_seq_id Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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