登録情報 | データベース: PDB / ID: 5h9r |
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タイトル | Crystal Structure of Human Galectin-3 CRD in Complex with TAZTDG |
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要素 | Galectin-3 |
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キーワード | SUGAR BINDING PROTEIN / galectin / thio-digalactoside (TDG) / pi-arginine interaction / fluorine bonding |
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機能・相同性 | 機能・相同性情報
: / negative regulation of immunological synapse formation / disaccharide binding / negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / RUNX2 regulates genes involved in differentiation of myeloid cells / regulation of T cell apoptotic process / mononuclear cell migration / positive regulation of mononuclear cell migration / negative regulation of endocytosis / IgE binding ...: / negative regulation of immunological synapse formation / disaccharide binding / negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / RUNX2 regulates genes involved in differentiation of myeloid cells / regulation of T cell apoptotic process / mononuclear cell migration / positive regulation of mononuclear cell migration / negative regulation of endocytosis / IgE binding / eosinophil chemotaxis / regulation of extrinsic apoptotic signaling pathway via death domain receptors / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / protein phosphatase inhibitor activity / negative regulation of T cell receptor signaling pathway / regulation of T cell proliferation / positive chemotaxis / macrophage chemotaxis / positive regulation of calcium ion import / chemoattractant activity / monocyte chemotaxis / Advanced glycosylation endproduct receptor signaling / ficolin-1-rich granule membrane / immunological synapse / laminin binding / epithelial cell differentiation / neutrophil chemotaxis / RNA splicing / secretory granule membrane / molecular condensate scaffold activity / negative regulation of extrinsic apoptotic signaling pathway / positive regulation of protein localization to plasma membrane / spliceosomal complex / positive regulation of protein-containing complex assembly / mRNA processing / carbohydrate binding / protein phosphatase binding / collagen-containing extracellular matrix / mitochondrial inner membrane / innate immune response / Neutrophil degranulation / cell surface / RNA binding / extracellular space / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Galectin-like / Galactoside-binding lectin / Galectin / Galectin, carbohydrate recognition domain / Galactoside-binding lectin / Galactoside-binding lectin (galectin) domain profile. / Jelly Rolls - #200 / Concanavalin A-like lectin/glucanase domain superfamily / Jelly Rolls / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.58 Å |
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データ登録者 | Hsieh, T.J. / Lin, H.Y. / Lin, C.H. |
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資金援助 | 台湾, 3件 組織 | 認可番号 | 国 |
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Academia Sinica | | 台湾 | Ministry of Science and Technology | 102-2113-M-001-001-MY3 | 台湾 | Ministry of Science and Technology | 102-2923-M-001-001-MY3 | 台湾 |
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引用 | ジャーナル: Sci Rep / 年: 2016 タイトル: Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors 著者: Hsieh, T.J. / Lin, H.Y. / Tu, Z. / Lin, T.C. / Wu, S.C. / Tseng, Y.Y. / Liu, F.T. / Danny Hsu, S.T. / Lin, C.H. |
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履歴 | 登録 | 2015年12月29日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2016年6月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年7月27日 | Group: Database references |
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改定 1.2 | 2023年11月8日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation |
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