登録情報 | データベース: PDB / ID: 5gjh |
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タイトル | Gads SH2 domain/CD28-derived peptide complex |
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要素 | - GRB2-related adapter protein 2
- T-cell-specific surface glycoprotein CD28
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キーワード | SIGNALING PROTEIN / Antigens / Phosphopeptides |
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機能・相同性 | 機能・相同性情報
Nef mediated downregulation of CD28 cell surface expression / positive regulation of inflammatory response to antigenic stimulus / regulatory T cell differentiation / protein complex involved in cell adhesion / regulation of regulatory T cell differentiation / positive regulation of isotype switching to IgG isotypes / CD4-positive, alpha-beta T cell proliferation / negative thymic T cell selection / positive regulation of CD4-positive, alpha-beta T cell proliferation / Co-stimulation by CD28 ...Nef mediated downregulation of CD28 cell surface expression / positive regulation of inflammatory response to antigenic stimulus / regulatory T cell differentiation / protein complex involved in cell adhesion / regulation of regulatory T cell differentiation / positive regulation of isotype switching to IgG isotypes / CD4-positive, alpha-beta T cell proliferation / negative thymic T cell selection / positive regulation of CD4-positive, alpha-beta T cell proliferation / Co-stimulation by CD28 / CD28 dependent Vav1 pathway / positive regulation of interleukin-4 production / regulation of MAPK cascade / humoral immune response / positive regulation of interleukin-10 production / Generation of second messenger molecules / immunological synapse / CD28 dependent PI3K/Akt signaling / positive regulation of viral genome replication / coreceptor activity / T cell costimulation / positive regulation of T cell proliferation / phosphotyrosine residue binding / FLT3 Signaling / FCERI mediated Ca+2 mobilization / positive regulation of interleukin-2 production / positive regulation of mitotic nuclear division / T cell activation / positive regulation of cytokine production / positive regulation of translation / FCERI mediated MAPK activation / phosphatidylinositol 3-kinase/protein kinase B signal transduction / apoptotic signaling pathway / Signaling by SCF-KIT / Signaling by CSF1 (M-CSF) in myeloid cells / Constitutive Signaling by Aberrant PI3K in Cancer / DAP12 signaling / cell-cell signaling / PIP3 activates AKT signaling / T cell receptor signaling pathway / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Ras protein signal transduction / transcription by RNA polymerase II / cell surface receptor signaling pathway / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / endosome / external side of plasma membrane / negative regulation of gene expression / positive regulation of gene expression / negative regulation of apoptotic process / protein kinase binding / cell surface / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 GRAP2, C-terminal SH3 domain / T cell antigen CD28 / ICOS V-set domain / Cytotoxic T-lymphocyte protein 4/CD28 / Grb2-like / SH2 domain / SHC Adaptor Protein / SH3 domain / SH2 domain / Immunoglobulin V-Type ...GRAP2, C-terminal SH3 domain / T cell antigen CD28 / ICOS V-set domain / Cytotoxic T-lymphocyte protein 4/CD28 / Grb2-like / SH2 domain / SHC Adaptor Protein / SH3 domain / SH2 domain / Immunoglobulin V-Type / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / Immunoglobulin V-set domain / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 GRB2-related adapter protein 2 / T-cell-specific surface glycoprotein CD28類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.2 Å |
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データ登録者 | Inaba, S. / Numoto, N. / Morii, H. / Ogawa, S. / Ikura, T. / Abe, R. / Ito, N. / Oda, M. |
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引用 | ジャーナル: J. Biol. Chem. / 年: 2017 タイトル: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins 著者: Inaba, S. / Numoto, N. / Ogawa, S. / Morii, H. / Ikura, T. / Abe, R. / Ito, N. / Oda, M. |
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履歴 | 登録 | 2016年6月30日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2016年12月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年2月1日 | Group: Database references |
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改定 1.2 | 2017年5月10日 | Group: Database references |
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改定 1.3 | 2023年11月8日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.4 | 2023年11月15日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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改定 1.5 | 2024年11月13日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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