Entry Database : PDB / ID : 5f86 Structure visualization Downloads & linksTitle Crystal structure of Drosophila Poglut1 (Rumi) complexed with its substrate protein (EGF repeat) ComponentsCoagulation factor IX O-glucosyltransferase rumi DetailsKeywords Transferase/Hydrolase / glycosyltransferase / protein O-glucosyltransferase / Notch regulation / EGF repeat / Transferase-Hydrolase complexFunction / homology Function and homology informationFunction Domain/homology Component
EGF-domain serine glucosyltransferase activity / EGF-domain serine xylosyltransferase activity / muscle tissue development / rhabdomere development / protein O-linked glycosylation via serine / UDP-xylosyltransferase activity / Defective F9 secretion / Defective gamma-carboxylation of F9 / coagulation factor IXa / UDP-glucosyltransferase activity ... EGF-domain serine glucosyltransferase activity / EGF-domain serine xylosyltransferase activity / muscle tissue development / rhabdomere development / protein O-linked glycosylation via serine / UDP-xylosyltransferase activity / Defective F9 secretion / Defective gamma-carboxylation of F9 / coagulation factor IXa / UDP-glucosyltransferase activity / glucosyltransferase activity / Defective F9 activation / protein O-linked glycosylation / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / zymogen activation / Extrinsic Pathway of Fibrin Clot Formation / Transferases; Glycosyltransferases; Hexosyltransferases / positive regulation of Notch signaling pathway / negative regulation of Notch signaling pathway / Protein hydroxylation / cell fate commitment / endomembrane system / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Removal of aminoterminal propeptides from gamma-carboxylated proteins / Notch signaling pathway / Intrinsic Pathway of Fibrin Clot Formation / Golgi lumen / blood coagulation / collagen-containing extracellular matrix / endopeptidase activity / endoplasmic reticulum lumen / serine-type endopeptidase activity / calcium ion binding / proteolysis / extracellular space / extracellular exosome / extracellular region / metal ion binding / plasma membrane Similarity search - Function Glycosyl transferase CAP10 domain / Glycosyl transferase family 90 / Putative lipopolysaccharide-modifying enzyme. / Endoplasmic reticulum targeting sequence. / Peptidase S1A, coagulation factor VII/IX/X/C/Z / Coagulation factor-like, Gla domain superfamily / Coagulation Factor Xa inhibitory site / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site ... Glycosyl transferase CAP10 domain / Glycosyl transferase family 90 / Putative lipopolysaccharide-modifying enzyme. / Endoplasmic reticulum targeting sequence. / Peptidase S1A, coagulation factor VII/IX/X/C/Z / Coagulation factor-like, Gla domain superfamily / Coagulation Factor Xa inhibitory site / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain superfamily / Vitamin K-dependent carboxylation domain. / Gla domain profile. / Domain containing Gla (gamma-carboxyglutamate) residues. / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan Similarity search - Domain/homologyBiological species Drosophila melanogaster (fruit fly)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 1.9 Å DetailsAuthors Yu, H.J. / Li, H.L. CitationJournal : Nat. Chem. Biol. / Year : 2016Title : Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations.Authors : Yu, H. / Takeuchi, H. / Takeuchi, M. / Liu, Q. / Kantharia, J. / Haltiwanger, R.S. / Li, H. History Deposition Dec 9, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 20, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Apr 18, 2018 Group : Data collection / Database references / Derived calculationsCategory : citation / citation_author / pdbx_struct_oper_listItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_struct_oper_list.symmetry_operation
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