Entry Database : PDB / ID : 5ejw Structure visualization Downloads & linksTitle Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351 ComponentsChromobox protein homolog 7 Details Keywords TRANSCRIPTION/INHIBITOR / transcription / inhibitor / TRANSCRIPTION-INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
sebaceous gland development / PRC1 complex / PcG protein complex / heterochromatin / methylated histone binding / positive regulation of transcription elongation by RNA polymerase II / chromatin organization / single-stranded RNA binding / chromatin binding / negative regulation of transcription by RNA polymerase II / nucleus Similarity search - Function Chromobox protein homolog 7 / CBX family C-terminal motif / CBX family C-terminal motif / Chromo domain subgroup / Chromo domain, conserved site / Chromo domain signature. / Chromo domain / Chromo (CHRromatin Organisation MOdifier) domain / Chromo and chromo shadow domain profile. / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 ... Chromobox protein homolog 7 / CBX family C-terminal motif / CBX family C-terminal motif / Chromo domain subgroup / Chromo domain, conserved site / Chromo domain signature. / Chromo domain / Chromo (CHRromatin Organisation MOdifier) domain / Chromo and chromo shadow domain profile. / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / Chromo/chromo shadow domain / Chromatin organization modifier domain / Chromo-like domain superfamily / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.6 Å DetailsAuthors Ren, C. / Zhou, M.M. CitationJournal : Acs Med.Chem.Lett. / Year : 2016Title : Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7.Authors : Ren, C. / Smith, S.G. / Yap, K. / Li, S. / Li, J. / Mezei, M. / Rodriguez, Y. / Vincek, A. / Aguilo, F. / Walsh, M.J. / Zhou, M.M. History Deposition Nov 2, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 9, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jul 6, 2016 Group : Database referencesRevision 1.2 Sep 27, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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