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TitleStructure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 7, Page 601-605, Year 2016
Publish dateNov 2, 2015 (structure data deposition date)
AuthorsRen, C. / Smith, S.G. / Yap, K. / Li, S. / Li, J. / Mezei, M. / Rodriguez, Y. / Vincek, A. / Aguilo, F. / Walsh, M.J. / Zhou, M.M.
External linksAcs Med. Chem. Lett. / PubMed:27326334
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-5ejw:
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with MS351
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-5PZ:
(1~{R})-2-[2-azanylidene-3-[(2-methylphenyl)methyl]benzimidazol-1-yl]-1-(3,4-dichlorophenyl)ethanol

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsTRANSCRIPTION/INHIBITOR / transcription / inhibitor / TRANSCRIPTION-INHIBITOR complex

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