登録情報 データベース : PDB / ID : 5e8r 構造の表示 ダウンロードとリンクタイトル Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) 要素Protein arginine N-methyltransferase 6 詳細 キーワード TRANSFERASE / HRMT1L6 / MS-023 / Structural Genomics / Structural Genomics Consortium / SGC機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H2AR3 methyltransferase activity / protein-arginine omega-N monomethyltransferase activity / histone H4R3 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / protein-arginine omega-N asymmetric methyltransferase activity / regulation of megakaryocyte differentiation / histone arginine N-methyltransferase activity / protein-arginine N-methyltransferase activity / regulation of mitochondrion organization ... histone H2AR3 methyltransferase activity / protein-arginine omega-N monomethyltransferase activity / histone H4R3 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / protein-arginine omega-N asymmetric methyltransferase activity / regulation of megakaryocyte differentiation / histone arginine N-methyltransferase activity / protein-arginine N-methyltransferase activity / regulation of mitochondrion organization / histone H3 methyltransferase activity / histone methyltransferase activity / negative regulation of ubiquitin-dependent protein catabolic process / regulation of signal transduction by p53 class mediator / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / protein modification process / base-excision repair / RMTs methylate histone arginines / cellular senescence / histone binding / methylation / chromatin remodeling / negative regulation of DNA-templated transcription / chromatin binding / nucleolus / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Methyltransferase domain 25 / Methyltransferase domain / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold ... Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Methyltransferase domain 25 / Methyltransferase domain / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 Chem-5L6 / S-ADENOSYL-L-HOMOCYSTEINE / Protein arginine N-methyltransferase 6 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 2.55 Å 詳細データ登録者 DONG, A. / ZENG, H. / LIU, J. / TEMPEL, W. / Seitova, A. / Hutchinson, A. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / JIN, J. ...DONG, A. / ZENG, H. / LIU, J. / TEMPEL, W. / Seitova, A. / Hutchinson, A. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / JIN, J. / BROWN, P.J. / WU, H. / Structural Genomics Consortium (SGC) 引用ジャーナル : Acs Chem.Biol. / 年 : 2016タイトル : A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.著者: Eram, M.S. / Shen, Y. / Szewczyk, M.M. / Wu, H. / Senisterra, G. / Li, F. / Butler, K.V. / Kaniskan, H.U. / Speed, B.A. / Dela Sena, C. / Dong, A. / Zeng, H. / Schapira, M. / Brown, P.J. / ... 著者 : Eram, M.S. / Shen, Y. / Szewczyk, M.M. / Wu, H. / Senisterra, G. / Li, F. / Butler, K.V. / Kaniskan, H.U. / Speed, B.A. / Dela Sena, C. / Dong, A. / Zeng, H. / Schapira, M. / Brown, P.J. / Arrowsmith, C.H. / Barsyte-Lovejoy, D. / Liu, J. / Vedadi, M. / Jin, J. 履歴 登録 2015年10月14日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年12月9日 Provider : repository / タイプ : Initial release改定 1.1 2016年3月30日 Group : Database references改定 1.2 2018年1月24日 Group : Derived calculations / Structure summary / カテゴリ : audit_author / pdbx_struct_oper_list / Item : _pdbx_struct_oper_list.symmetry_operation改定 1.3 2024年3月6日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
すべて表示 表示を減らす