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TitleA Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.
Journal, issue, pagesAcs Chem. Biol., Vol. 11, Page 772-781, Year 2016
Publish dateOct 14, 2015 (structure data deposition date)
AuthorsEram, M.S. / Shen, Y. / Szewczyk, M.M. / Wu, H. / Senisterra, G. / Li, F. / Butler, K.V. / Kaniskan, H.U. / Speed, B.A. / Dela Sena, C. ...Eram, M.S. / Shen, Y. / Szewczyk, M.M. / Wu, H. / Senisterra, G. / Li, F. / Butler, K.V. / Kaniskan, H.U. / Speed, B.A. / Dela Sena, C. / Dong, A. / Zeng, H. / Schapira, M. / Brown, P.J. / Arrowsmith, C.H. / Barsyte-Lovejoy, D. / Liu, J. / Vedadi, M. / Jin, J.
External linksAcs Chem. Biol. / PubMed:26598975
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-5e8r:
Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae)
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-5L6:
N-methyl-N-({4-[4-(propan-2-yloxy)phenyl]-1H-pyrrol-3-yl}methyl)ethane-1,2-diamine

ChemComp-CL:
Unknown entry

ChemComp-UNX:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / HRMT1L6 / MS-023 / Structural Genomics / Structural Genomics Consortium / SGC

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