Entry Database : PDB / ID : 5d12 Structure visualization Downloads & linksTitle Kinase domain of cSrc in complex with RL40 ComponentsProto-oncogene tyrosine-protein kinase Src Details Keywords TRANSFERASE / kinase inhibitor / drug resistanceFunction / homology Function and homology informationFunction Domain/homology Component
Signaling by ERBB2 / Nuclear signaling by ERBB4 / PIP3 activates AKT signaling / Signaling by SCF-KIT / Regulation of KIT signaling / Signaling by EGFR / GAB1 signalosome / Regulation of gap junction activity / FCGR activation / PECAM1 interactions ... Signaling by ERBB2 / Nuclear signaling by ERBB4 / PIP3 activates AKT signaling / Signaling by SCF-KIT / Regulation of KIT signaling / Signaling by EGFR / GAB1 signalosome / Regulation of gap junction activity / FCGR activation / PECAM1 interactions / CD28 co-stimulation / CTLA4 inhibitory signaling / EPHA-mediated growth cone collapse / Ephrin signaling / G alpha (i) signalling events / GP1b-IX-V activation signalling / Thrombin signalling through proteinase activated receptors (PARs) / VEGFR2 mediated cell proliferation / RAF activation / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RET signaling / Receptor Mediated Mitophagy / ADP signalling through P2Y purinoceptor 1 / Downregulation of ERBB4 signaling / EPH-ephrin mediated repulsion of cells / Cyclin D associated events in G1 / Regulation of RUNX3 expression and activity / Activated NTRK3 signals through PI3K / Downstream signal transduction / MAP2K and MAPK activation / Integrin signaling / GRB2:SOS provides linkage to MAPK signaling for Integrins / DCC mediated attractive signaling / MET activates PTK2 signaling / Extra-nuclear estrogen signaling / EPHB-mediated forward signaling / p130Cas linkage to MAPK signaling for integrins / VEGFA-VEGFR2 Pathway / connexin binding / osteoclast development / progesterone receptor signaling pathway / negative regulation of intrinsic apoptotic signaling pathway / bone resorption / extrinsic component of cytoplasmic side of plasma membrane / negative regulation of extrinsic apoptotic signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / epidermal growth factor receptor signaling pathway / cell junction / protein phosphatase binding / protein tyrosine kinase activity / mitochondrial inner membrane / cell differentiation / cytoskeleton / endosome membrane / cell adhesion / regulation of cell cycle / cell cycle / phosphorylation / innate immune response / focal adhesion / signaling receptor binding / heme binding / perinuclear region of cytoplasm / protein-containing complex / ATP binding / membrane / nucleus / plasma membrane / cytosol Similarity search - Function SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain ... SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Gallus gallus (chicken)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 3 Å DetailsAuthors Becker, C. / Richters, A. / Engel, J. / Rauh, D. CitationJournal : J.Med.Chem. / Year : 2015Title : Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.Authors: Engel, J. / Richters, A. / Getlik, M. / Tomassi, S. / Keul, M. / Termathe, M. / Lategahn, J. / Becker, C. / Mayer-Wrangowski, S. / Grutter, C. / Uhlenbrock, N. / Krull, J. / Schaumann, N. / ... Authors : Engel, J. / Richters, A. / Getlik, M. / Tomassi, S. / Keul, M. / Termathe, M. / Lategahn, J. / Becker, C. / Mayer-Wrangowski, S. / Grutter, C. / Uhlenbrock, N. / Krull, J. / Schaumann, N. / Eppmann, S. / Kibies, P. / Hoffgaard, F. / Heil, J. / Menninger, S. / Ortiz-Cuaran, S. / Heuckmann, J.M. / Tinnefeld, V. / Zahedi, R.P. / Sos, M.L. / Schultz-Fademrecht, C. / Thomas, R.K. / Kast, S.M. / Rauh, D. History Deposition Aug 3, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Sep 9, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Sep 23, 2015 Group : Database referencesRevision 1.2 Feb 20, 2019 Group : Advisory / Data collection / Derived calculationsCategory : pdbx_data_processing_status / pdbx_validate_close_contact ... pdbx_data_processing_status / pdbx_validate_close_contact / struct_conn / struct_conn_type Revision 1.3 May 8, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less