登録情報 | データベース: PDB / ID: 5ckr |
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タイトル | Crystal Structure of MraY in complex with Muraymycin D2 |
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要素 | Phospho-N-acetylmuramoyl-pentapeptide-transferase |
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キーワード | TRANSFERASE/ANTIBIOTIC / ALPHA-HELICAL / PNPT Superfamily / phospho-MurNAc-pentapeptide translocase / Membrane Protein / Bacterial cell wall / synthesis / natural product inhibitor / TRANSFERASE-ANTIBIOTIC complex |
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機能・相同性 | 機能・相同性情報
phospho-N-acetylmuramoyl-pentapeptide-transferase / UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity / phospho-N-acetylmuramoyl-pentapeptide-transferase activity / cell wall macromolecule biosynthetic process / phosphotransferase activity, for other substituted phosphate groups / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / cell cycle / cell division ...phospho-N-acetylmuramoyl-pentapeptide-transferase / UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity / phospho-N-acetylmuramoyl-pentapeptide-transferase activity / cell wall macromolecule biosynthetic process / phosphotransferase activity, for other substituted phosphate groups / peptidoglycan biosynthetic process / cell wall organization / regulation of cell shape / cell cycle / cell division / identical protein binding / metal ion binding / plasma membrane類似検索 - 分子機能 Phospho-N-acetylmuramoyl-pentapeptide transferase / Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site / Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 / MraY family signature 1. / MraY family signature 2. / Glycosyl transferase, family 4 / Glycosyl transferase family 4類似検索 - ドメイン・相同性 Muraymycin D2 / Phospho-N-acetylmuramoyl-pentapeptide-transferase類似検索 - 構成要素 |
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生物種 | Aquifex aeolicus (バクテリア) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.95 Å |
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データ登録者 | Lee, S.Y. / Chung, B.C. / Mashalidis, E.H. / Tanino, T. / Kim, M. / Hong, J. / Ichikawa, S. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01 GM100984 | 米国 |
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引用 | ジャーナル: Nature / 年: 2016 タイトル: Structural insights into inhibition of lipid I production in bacterial cell wall synthesis. 著者: Chung, B.C. / Mashalidis, E.H. / Tanino, T. / Kim, M. / Matsuda, A. / Hong, J. / Ichikawa, S. / Lee, S.Y. |
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履歴 | 登録 | 2015年7月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年3月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年6月1日 | Group: Database references |
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改定 1.2 | 2017年9月27日 | Group: Author supporting evidence / Database references ...Author supporting evidence / Database references / Derived calculations / Refinement description カテゴリ: citation / pdbx_audit_support ...citation / pdbx_audit_support / pdbx_struct_oper_list / software Item: _citation.journal_id_CSD / _pdbx_audit_support.funding_organization ..._citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation / _software.classification |
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改定 1.3 | 2019年12月25日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2023年9月27日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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