登録情報 データベース : PDB / ID : 5ckn 構造の表示 ダウンロードとリンクタイトル The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+ 要素Mannan-binding lectin serine peptidase 2 詳細 キーワード HYDROLASE / MASP / CUB1-EGF-CUB2 / Complement activation / lectin pathway機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
mannan-binding lectin-associated serine protease-2 / Ficolins bind to repetitive carbohydrate structures on the target cell surface / complement component C4b binding / Lectin pathway of complement activation / Initial triggering of complement / complement activation, lectin pathway / complement activation / complement activation, classical pathway / calcium-dependent protein binding / peptidase activity ... mannan-binding lectin-associated serine protease-2 / Ficolins bind to repetitive carbohydrate structures on the target cell surface / complement component C4b binding / Lectin pathway of complement activation / Initial triggering of complement / complement activation, lectin pathway / complement activation / complement activation, classical pathway / calcium-dependent protein binding / peptidase activity / serine-type endopeptidase activity / calcium ion binding / proteolysis / extracellular space 類似検索 - 分子機能 Spermadhesin, CUB domain / Peptidase S1A, complement C1r/C1S/mannan-binding / CUB domain / Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. / CUB domain / CUB domain profile. / Spermadhesin, CUB domain superfamily / : / Calcium-binding EGF domain / Sushi repeat (SCR repeat) ... Spermadhesin, CUB domain / Peptidase S1A, complement C1r/C1S/mannan-binding / CUB domain / Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. / CUB domain / CUB domain profile. / Spermadhesin, CUB domain superfamily / : / Calcium-binding EGF domain / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Laminin / Laminin / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / EGF-like domain signature 2. / EGF-like domain / Ribbon / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Jelly Rolls / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性 MBL associated serine protease 2 / Mannan-binding lectin serine protease 2 類似検索 - 構成要素生物種 Rattus norvegicus (ドブネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.6 Å 詳細データ登録者 Nan, R. / Furze, C.M. / Wright, D.W. / Gor, J. / Wallis, R. / Perkins, S.J. 資金援助 英国, 2件 詳細 詳細を隠す組織 認可番号 国 Medical Research Council (United Kingdom) MR/K011715/1 英国 Engineering and Physical Sciences Research Council EP/K039121/1 英国
引用ジャーナル : Structure / 年 : 2017タイトル : Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.著者 : Nan, R. / Furze, C.M. / Wright, D.W. / Gor, J. / Wallis, R. / Perkins, S.J. 履歴 登録 2015年7月15日 登録サイト : RCSB / 処理サイト : PDBE改定 1.0 2017年1月18日 Provider : repository / タイプ : Initial release改定 1.1 2017年2月1日 Group : Database references改定 1.2 2017年2月15日 Group : Database references改定 1.3 2017年9月13日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.4 2024年1月10日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id
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