Entry Database : PDB / ID : 5bxu Structure visualization Downloads & linksTitle Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5 Components Details Keywords TRANSFERASE / stapled peptide / protein-protein interaction / ankyrin-repeat domain / tankyraseFunction / homology Function and homology informationFunction Domain/homology Component
XAV939 stabilizes AXIN / NAD+ ADP-ribosyltransferase / protein localization to chromosome, telomeric region / negative regulation of telomere maintenance via telomere lengthening / protein auto-ADP-ribosylation / protein poly-ADP-ribosylation / pericentriolar material / positive regulation of telomere capping / NAD+-protein ADP-ribosyltransferase activity / NAD+-protein poly-ADP-ribosyltransferase activity ... XAV939 stabilizes AXIN / NAD+ ADP-ribosyltransferase / protein localization to chromosome, telomeric region / negative regulation of telomere maintenance via telomere lengthening / protein auto-ADP-ribosylation / protein poly-ADP-ribosylation / pericentriolar material / positive regulation of telomere capping / NAD+-protein ADP-ribosyltransferase activity / NAD+-protein poly-ADP-ribosyltransferase activity / Transferases; Glycosyltransferases; Pentosyltransferases / positive regulation of telomere maintenance via telomerase / nucleotidyltransferase activity / TCF dependent signaling in response to WNT / Degradation of AXIN / Wnt signaling pathway / Regulation of PTEN stability and activity / protein polyubiquitination / positive regulation of canonical Wnt signaling pathway / nuclear envelope / chromosome, telomeric region / Ub-specific processing proteases / Golgi membrane / perinuclear region of cytoplasm / enzyme binding / nucleus / metal ion binding / cytosol / cytoplasm Similarity search - Function : / Ankyrin repeat / Ankyrin repeat-containing domain / Ankyrin repeats (many copies) / Poly(ADP-ribose) polymerase catalytic domain / Poly(ADP-ribose) polymerase, catalytic domain / PARP catalytic domain profile. / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. ... : / Ankyrin repeat / Ankyrin repeat-containing domain / Ankyrin repeats (many copies) / Poly(ADP-ribose) polymerase catalytic domain / Poly(ADP-ribose) polymerase, catalytic domain / PARP catalytic domain profile. / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / Ankyrin repeat / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.35 Å DetailsAuthors Xu, W. / Fischer, G. / Hyvonen, M. / Itzhaki, L. Funding support United Kingdom, 1items Details Hide detailsOrganization Grant number Country Medical Research Council (United Kingdom) G1002329 United Kingdom
CitationJournal : to be published Title : Human Tankyrase-2 in Complex with Extended Stapled Peptide sp4n4m5Authors : Xu, W. / Lau, Y.H. / Fischer, G. / Chattopadhyay, A. / Tan, Y.S. / Verma, C. / Hyvonen, M. / Spring, D.S. / Itzhaki, L.S. History Deposition Jun 9, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Jun 29, 2016 Provider : repository / Type : Initial releaseRevision 2.0 Sep 13, 2017 Group : Advisory / Atomic model ... Advisory / Atomic model / Author supporting evidence / Data collection / Derived calculations Category : atom_site / diffrn_radiation_wavelength ... atom_site / diffrn_radiation_wavelength / pdbx_audit_support / pdbx_unobs_or_zero_occ_atoms / pdbx_validate_close_contact / pdbx_validate_symm_contact / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _pdbx_audit_support.funding_organization / _pdbx_validate_close_contact.auth_seq_id_1 / _pdbx_validate_symm_contact.auth_seq_id_2 / _struct_site_gen.auth_seq_id Revision 3.0 Nov 15, 2023 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Refinement description Category : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_atoms / software Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _software.name Revision 3.1 Feb 7, 2024 Group : Refinement description / Category : pdbx_initial_refinement_model
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