Entry Database : PDB / ID : 5b4y Structure visualization Downloads & linksTitle Crystal structure of the LA12 fragment of ApoER2 ComponentsLow-density lipoprotein receptor-related protein 8 Details Keywords SIGNALING PROTEIN / signal transductionFunction / homology Function and homology informationFunction Domain/homology Component
ammon gyrus development / reelin receptor activity / positive regulation of CREB transcription factor activity / ventral spinal cord development / very-low-density lipoprotein particle receptor activity / reelin-mediated signaling pathway / high-density lipoprotein particle binding / low-density lipoprotein particle receptor activity / layer formation in cerebral cortex / cellular response to cholesterol ... ammon gyrus development / reelin receptor activity / positive regulation of CREB transcription factor activity / ventral spinal cord development / very-low-density lipoprotein particle receptor activity / reelin-mediated signaling pathway / high-density lipoprotein particle binding / low-density lipoprotein particle receptor activity / layer formation in cerebral cortex / cellular response to cholesterol / positive regulation of dendritic spine morphogenesis / positive regulation of dendrite development / dendrite morphogenesis / cargo receptor activity / retinoid metabolic process / microtubule associated complex / Platelet sensitization by LDL / regulation of innate immune response / kinesin binding / apolipoprotein binding / positive regulation of protein tyrosine kinase activity / Retinoid metabolism and transport / caveola / modulation of chemical synaptic transmission / lipid metabolic process / cellular response to growth factor stimulus / cytokine-mediated signaling pathway / endocytosis / transmembrane signaling receptor activity / calcium-dependent protein binding / positive regulation of peptidyl-tyrosine phosphorylation / amyloid-beta binding / chemical synaptic transmission / regulation of apoptotic process / receptor complex / response to xenobiotic stimulus / axon / neuronal cell body / synapse / calcium ion binding / dendrite / cell surface / signal transduction / proteolysis / extracellular space / membrane / plasma membrane Similarity search - Function Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / Low-density lipoprotein receptor domain class A / : / Low-density lipoprotein (LDL) receptor class A, conserved site / LDL-receptor class A (LDLRA) domain signature. / LDL-receptor class A (LDLRA) domain profile. / Calcium-binding EGF domain ... Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / Low-density lipoprotein receptor domain class A / : / Low-density lipoprotein (LDL) receptor class A, conserved site / LDL-receptor class A (LDLRA) domain signature. / LDL-receptor class A (LDLRA) domain profile. / Calcium-binding EGF domain / Low-density lipoprotein receptor domain class A / Low-density lipoprotein (LDL) receptor class A repeat / LDL receptor-like superfamily / Six-bladed beta-propeller, TolB-like / Coagulation Factor Xa inhibitory site / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Nogi, T. / Tabata, S. / Hirai, H. / Yasui, N. / Takagi, J. CitationJournal : To Be Published Title : Crystal structure of the ectodomain from a LDLR close homologue in complex with its physiological ligand.Authors : Hirai, H. / Yasui, N. / Yamashita, K. / Tabata, S. / Yamamoto, M. / Takagi, J. / Nogi, T. History Deposition Apr 20, 2016 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Apr 26, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Feb 26, 2020 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.pdbx_synchrotron_siteRevision 1.2 Nov 8, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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