Entry Database : PDB / ID : 5b4x Structure visualization Downloads & linksTitle Crystal structure of the ApoER2 ectodomain in complex with the Reelin R56 fragment ComponentsLow density lipoprotein receptor-related protein 8, apolipoprotein e receptor, isoform CRA_e Reelin DetailsKeywords SIGNALING PROTEIN/ENDOCYTOSIS / signal transduction / MEMBRANE PROTEIN / SIGNALING PROTEIN-ENDOCYTOSIS complexFunction / homology Function and homology informationFunction Domain/homology Component
ammon gyrus development / spinal cord patterning / cerebral cortex tangential migration / reelin complex / positive regulation of lateral motor column neuron migration / lateral motor column neuron migration / Reelin signalling pathway / lipoprotein particle receptor binding / reelin receptor activity / regulation of synaptic activity ... ammon gyrus development / spinal cord patterning / cerebral cortex tangential migration / reelin complex / positive regulation of lateral motor column neuron migration / lateral motor column neuron migration / Reelin signalling pathway / lipoprotein particle receptor binding / reelin receptor activity / regulation of synaptic activity / interneuron migration / postsynaptic density protein 95 clustering / positive regulation of CREB transcription factor activity / postsynaptic density assembly / ventral spinal cord development / very-low-density lipoprotein particle receptor activity / regulation of behavior / reelin-mediated signaling pathway / high-density lipoprotein particle binding / positive regulation of synapse maturation / low-density lipoprotein particle receptor activity / motor neuron migration / layer formation in cerebral cortex / receptor localization to synapse / glial cell differentiation / regulation of neuron migration / cellular response to cholesterol / protein localization to synapse / NMDA glutamate receptor clustering / positive regulation of dendritic spine morphogenesis / regulation of synapse maturation / very-low-density lipoprotein particle receptor binding / dentate gyrus development / positive regulation of small GTPase mediated signal transduction / positive regulation of AMPA receptor activity / regulation of NMDA receptor activity / positive regulation of dendrite development / dendrite morphogenesis / cargo receptor activity / microtubule associated complex / retinoid metabolic process / regulation of neuron differentiation / Platelet sensitization by LDL / response to pain / regulation of innate immune response / dendrite development / kinesin binding / associative learning / positive regulation of excitatory postsynaptic potential / apolipoprotein binding / positive regulation of protein tyrosine kinase activity / Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases / positive regulation of TOR signaling / long-term memory / Retinoid metabolism and transport / forebrain development / serine-type peptidase activity / extracellular matrix / positive regulation of synaptic transmission, glutamatergic / learning / positive regulation of long-term synaptic potentiation / caveola / central nervous system development / axon guidance / locomotory behavior / hippocampus development / long-term synaptic potentiation / neuron migration / modulation of chemical synaptic transmission / brain development / cell morphogenesis / lipid metabolic process / cellular response to growth factor stimulus / cerebral cortex development / positive regulation of neuron projection development / cytokine-mediated signaling pathway / endocytosis / transmembrane signaling receptor activity / calcium-dependent protein binding / positive regulation of peptidyl-tyrosine phosphorylation / cell migration / amyloid-beta binding / regulation of gene expression / chemical synaptic transmission / perikaryon / collagen-containing extracellular matrix / regulation of apoptotic process / membrane => GO:0016020 / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor complex / receptor ligand activity / cell adhesion / neuron projection / response to xenobiotic stimulus / positive regulation of protein phosphorylation / axon / neuronal cell body / synapse / dendrite / calcium ion binding Similarity search - Function : / Reelin subrepeat B / Reelin / Reeler domain / Reeler domain superfamily / Reelin domain profile. / Tenascin, EGF-like domain / Tenascin EGF domain / : / Low-density lipoprotein receptor repeat class B ... : / Reelin subrepeat B / Reelin / Reeler domain / Reeler domain superfamily / Reelin domain profile. / Tenascin, EGF-like domain / Tenascin EGF domain / : / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / Low-density lipoprotein receptor domain class A / : / Low-density lipoprotein (LDL) receptor class A, conserved site / LDL-receptor class A (LDLRA) domain signature. / LDL-receptor class A (LDLRA) domain profile. / Calcium-binding EGF domain / Low-density lipoprotein receptor domain class A / Low-density lipoprotein (LDL) receptor class A repeat / LDL receptor-like superfamily / Six-bladed beta-propeller, TolB-like / Coagulation Factor Xa inhibitory site / Sialidase superfamily / Galactose-binding domain-like / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Jelly Rolls / Sandwich / Mainly Beta Similarity search - Domain/homology Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, isoform CRA_e / Low-density lipoprotein receptor-related protein 8 / Reelin Similarity search - ComponentBiological species Mus musculus (house mouse)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 3.2 Å DetailsAuthors Yasui, N. / Hirai, H. / Yamashita, K. / Takagi, J. / Nogi, T. Funding support Japan, 4items Details Hide detailsOrganization Grant number Country JSPS 22247010 Japan JSPS 20770084 Japan JSPS 05J09821 Japan MEXT 17082004 Japan
CitationJournal : To Be Published Title : Crystal structure of the ectodomain from a LDLR close homologue in complex with its physiological ligand.Authors : Hirai, H. / Yasui, N. / Yamashita, K. / Tabata, S. / Yamamoto, M. / Takagi, J. / Nogi, T. History Deposition Apr 20, 2016 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Apr 26, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Feb 26, 2020 Group : Data collection / Category : chem_comp / diffrn_sourceItem : _chem_comp.type / _diffrn_source.pdbx_synchrotron_siteRevision 1.2 Jul 29, 2020 Group : Data collection / Derived calculations / Structure summaryCategory : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_conn_type / struct_site / struct_site_gen Item : _chem_comp.name / _entity.pdbx_description ... _chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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