Entry Database : PDB / ID : 4zw2 Structure visualization Downloads & linksTitle Crystal structure of the Mouse voltage gated calcium channel beta subunit isoform 1a in complex with Alpha Interaction Domain peptide. ComponentsVoltage-dependent L-type calcium channel subunit alpha-1S Voltage-dependent L-type calcium channel subunit beta-1,Voltage-dependent L-type calcium channel subunit beta-1 DetailsKeywords METAL TRANSPORT / dihydropyridine receptor / CaVbeta / excitation contraction coupling / Alpha Interacting DomainFunction / homology Function and homology informationFunction Domain/homology Component
skeletal muscle adaptation / Phase 2 - plateau phase / Phase 0 - rapid depolarisation / extraocular skeletal muscle development / Presynaptic depolarization and calcium channel opening / regulation of voltage-gated calcium channel activity / positive regulation of muscle contraction / high voltage-gated calcium channel activity / L-type voltage-gated calcium channel complex / muscle cell development ... skeletal muscle adaptation / Phase 2 - plateau phase / Phase 0 - rapid depolarisation / extraocular skeletal muscle development / Presynaptic depolarization and calcium channel opening / regulation of voltage-gated calcium channel activity / positive regulation of muscle contraction / high voltage-gated calcium channel activity / L-type voltage-gated calcium channel complex / muscle cell development / myoblast fusion / calcium ion import / endoplasmic reticulum organization / I band / regulation of monoatomic ion transmembrane transport / protein targeting to membrane / regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / voltage-gated calcium channel complex / neuromuscular junction development / dendritic spine head / cellular response to caffeine / voltage-gated calcium channel activity / skeletal muscle fiber development / striated muscle contraction / skeletal muscle tissue development / T-tubule / skeletal system development / sarcoplasmic reticulum / muscle contraction / calcium ion transmembrane transport / phosphoprotein binding / sarcolemma / cellular response to amyloid-beta / calcium ion transport / presynapse / postsynapse / chemical synaptic transmission / calmodulin binding / protein domain specific binding / glutamatergic synapse / protein kinase binding / identical protein binding / metal ion binding / plasma membrane / cytoplasm Similarity search - Function Voltage-dependent calcium channel, L-type, beta-1 subunit / Voltage-dependent calcium channel, L-type, alpha-1S subunit / Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain / Voltage-dependent calcium channel, L-type, beta subunit / Voltage gated calcium channel subunit beta domain 4Aa N terminal / Voltage-gated calcium channel subunit alpha, C-terminal / Voltage-gated calcium channel subunit alpha, C-term / Voltage-dependent calcium channel, L-type, alpha-1 subunit / Voltage-dependent calcium channel, alpha-1 subunit, IQ domain / Voltage gated calcium channel IQ domain ... Voltage-dependent calcium channel, L-type, beta-1 subunit / Voltage-dependent calcium channel, L-type, alpha-1S subunit / Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain / Voltage-dependent calcium channel, L-type, beta subunit / Voltage gated calcium channel subunit beta domain 4Aa N terminal / Voltage-gated calcium channel subunit alpha, C-terminal / Voltage-gated calcium channel subunit alpha, C-term / Voltage-dependent calcium channel, L-type, alpha-1 subunit / Voltage-dependent calcium channel, alpha-1 subunit, IQ domain / Voltage gated calcium channel IQ domain / Voltage gated calcium channel IQ domain / Voltage-dependent calcium channel, alpha-1 subunit / Voltage-dependent L-type calcium channel, IQ-associated domain / Voltage-dependent L-type calcium channel, IQ-associated / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / SH3 Domains / Voltage-dependent channel domain superfamily / SH3 type barrels. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Ion transport domain / Ion transport protein / P-loop containing nucleotide triphosphate hydrolases / Roll / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homology TRIETHYLENE GLYCOL / Voltage-dependent L-type calcium channel subunit alpha-1S / Voltage-dependent L-type calcium channel subunit beta-1 Similarity search - ComponentBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 1.86 Å DetailsAuthors Norris, N.C. / Oakley, A.J. CitationJournal : J. Biol. Chem. / Year : 2017Title : Structural and biophysical analyses of the skeletal dihydropyridine receptor beta subunit beta 1a reveal critical roles of domain interactions for stability.Authors : Norris, N.C. / Joseph, S. / Aditya, S. / Karunasekara, Y. / Board, P.G. / Dulhunty, A.F. / Oakley, A.J. / Casarotto, M.G. History Deposition May 19, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 1, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jul 27, 2016 Group : Data collectionRevision 1.2 Aug 2, 2017 Group : Database references / Derived calculationsCategory : citation / citation_author / pdbx_struct_oper_listItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _pdbx_struct_oper_list.symmetry_operation Revision 1.3 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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