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- PDB-4z32: Crystal Structure of the FERM-SH2 Domains of Jak2 -

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Basic information

Entry
Database: PDB / ID: 4z32
TitleCrystal Structure of the FERM-SH2 Domains of Jak2
ComponentsTyrosine-protein kinase JAK2
KeywordsTRANSFERASE / JAK-STAT / FERM Domain / SH2 Domain / Cytokine Receptor
Function / homology
Function and homology information


interleukin-35-mediated signaling pathway / nuclear receptor-mediated mineralocorticoid signaling pathway / histone H3Y41 kinase activity / activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / positive regulation of growth factor dependent skeletal muscle satellite cell proliferation / symbiont-induced defense-related programmed cell death / mammary gland epithelium development / regulation of postsynapse to nucleus signaling pathway / positive regulation of growth hormone receptor signaling pathway / granulocyte macrophage colony-stimulating factor receptor complex ...interleukin-35-mediated signaling pathway / nuclear receptor-mediated mineralocorticoid signaling pathway / histone H3Y41 kinase activity / activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / positive regulation of growth factor dependent skeletal muscle satellite cell proliferation / symbiont-induced defense-related programmed cell death / mammary gland epithelium development / regulation of postsynapse to nucleus signaling pathway / positive regulation of growth hormone receptor signaling pathway / granulocyte macrophage colony-stimulating factor receptor complex / granulocyte-macrophage colony-stimulating factor signaling pathway / Signaling by Erythropoietin / collagen-activated signaling pathway / interleukin-12 receptor binding / Erythropoietin activates STAT5 / interleukin-5-mediated signaling pathway / response to interleukin-12 / Erythropoietin activates Phospholipase C gamma (PLCG) / positive regulation of leukocyte proliferation / post-embryonic hemopoiesis / interleukin-12 receptor complex / activation of Janus kinase activity / tyrosine phosphorylation of STAT protein / interleukin-23 receptor complex / positive regulation of MHC class II biosynthetic process / positive regulation of platelet aggregation / Interleukin-23 signaling / type 1 angiotensin receptor binding / positive regulation of T-helper 17 type immune response / positive regulation of platelet activation / acetylcholine receptor binding / positive regulation of NK T cell proliferation / interleukin-12-mediated signaling pathway / cellular response to interleukin-3 / interleukin-3-mediated signaling pathway / Signaling by Leptin / regulation of nitric oxide biosynthetic process / positive regulation of signaling receptor activity / Interleukin-12 signaling / Interleukin-27 signaling / IL-6-type cytokine receptor ligand interactions / Interleukin-35 Signalling / positive regulation of epithelial cell apoptotic process / response to hydroperoxide / positive regulation of natural killer cell proliferation / positive regulation of cell-substrate adhesion / regulation of receptor signaling pathway via JAK-STAT / growth hormone receptor binding / axon regeneration / growth hormone receptor signaling pathway / peptide hormone receptor binding / negative regulation of cardiac muscle cell apoptotic process / intrinsic apoptotic signaling pathway in response to oxidative stress / extrinsic component of plasma membrane / IFNG signaling activates MAPKs / Interleukin-20 family signaling / interleukin-6-mediated signaling pathway / negative regulation of cell-cell adhesion / Interleukin-6 signaling / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / enzyme-linked receptor protein signaling pathway / Prolactin receptor signaling / MAPK3 (ERK1) activation / response to amine / positive regulation of interleukin-17 production / negative regulation of DNA binding / positive regulation of nitric-oxide synthase biosynthetic process / MAPK1 (ERK2) activation / cell surface receptor signaling pathway via JAK-STAT / mesoderm development / positive regulation of SMAD protein signal transduction / platelet-derived growth factor receptor signaling pathway / insulin receptor substrate binding / Interleukin-3, Interleukin-5 and GM-CSF signaling / growth hormone receptor signaling pathway via JAK-STAT / response to tumor necrosis factor / Interleukin receptor SHC signaling / phosphatidylinositol 3-kinase binding / Regulation of IFNG signaling / type II interferon-mediated signaling pathway / Erythropoietin activates RAS / Growth hormone receptor signaling / extrinsic apoptotic signaling pathway / positive regulation of T cell proliferation / Signaling by CSF3 (G-CSF) / positive regulation of tyrosine phosphorylation of STAT protein / extrinsic component of cytoplasmic side of plasma membrane / positive regulation of vascular associated smooth muscle cell proliferation / tumor necrosis factor-mediated signaling pathway / actin filament polymerization / SH2 domain binding / cellular response to dexamethasone stimulus / erythrocyte differentiation / post-translational protein modification / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / positive regulation of interleukin-1 beta production / caveola / endosome lumen / positive regulation of cell differentiation / positive regulation of apoptotic signaling pathway
Similarity search - Function
Tyrosine-protein kinase, non-receptor Jak2 / Janus kinase 2, pseudokinase domain / Janus kinase 2, catalytic domain / Tyrosine-protein kinase JAK2, SH2 domain / JAK2, FERM domain C-lobe / Tyrosine-protein kinase, non-receptor Jak/Tyk2 / JAK, FERM F2 lobe domain / FERM F1 lobe ubiquitin-like domain / JAK1-3/TYK2, pleckstrin homology-like domain / Jak1 pleckstrin homology-like domain ...Tyrosine-protein kinase, non-receptor Jak2 / Janus kinase 2, pseudokinase domain / Janus kinase 2, catalytic domain / Tyrosine-protein kinase JAK2, SH2 domain / JAK2, FERM domain C-lobe / Tyrosine-protein kinase, non-receptor Jak/Tyk2 / JAK, FERM F2 lobe domain / FERM F1 lobe ubiquitin-like domain / JAK1-3/TYK2, pleckstrin homology-like domain / Jak1 pleckstrin homology-like domain / FERM F2 acyl-CoA binding protein-like domain / FERM F1 ubiquitin-like domain / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily
Similarity search - Domain/homology
Tyrosine-protein kinase JAK2
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.04 Å
AuthorsMcNally, R. / Eck, M.J.
CitationJournal: Plos One / Year: 2016
Title: Crystal Structure of the FERM-SH2 Module of Human Jak2.
Authors: McNally, R. / Toms, A.V. / Eck, M.J.
History
DepositionMar 30, 2015Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jun 22, 2016Provider: repository / Type: Initial release
Revision 1.1Sep 27, 2023Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Tyrosine-protein kinase JAK2
B: Tyrosine-protein kinase JAK2
C: Tyrosine-protein kinase JAK2
D: Tyrosine-protein kinase JAK2
E: Tyrosine-protein kinase JAK2
F: Tyrosine-protein kinase JAK2
G: Tyrosine-protein kinase JAK2
H: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)461,4538
Polymers461,4538
Non-polymers00
Water21612
1
A: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)57,6821
Polymers57,6821
Non-polymers00
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
2
B: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)57,6821
Polymers57,6821
Non-polymers00
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
3
C: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)57,6821
Polymers57,6821
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
4
D: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)57,6821
Polymers57,6821
Non-polymers00
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
5
E: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)57,6821
Polymers57,6821
Non-polymers00
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
6
F: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)57,6821
Polymers57,6821
Non-polymers00
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
7
G: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)57,6821
Polymers57,6821
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
8
H: Tyrosine-protein kinase JAK2


Theoretical massNumber of molelcules
Total (without water)57,6821
Polymers57,6821
Non-polymers00
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
Unit cell
Length a, b, c (Å)118.193, 188.742, 118.585
Angle α, β, γ (deg.)90.00, 113.87, 90.00
Int Tables number4
Space group name H-MP1211

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Components

#1: Protein
Tyrosine-protein kinase JAK2 / Janus kinase 2 / JAK-2


Mass: 57681.648 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: JAK2 / Production host: Trichoplusia ni (cabbage looper)
References: UniProt: O60674, non-specific protein-tyrosine kinase
#2: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 12 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION

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Sample preparation

CrystalDensity Matthews: 2.62 Å3/Da / Density % sol: 57.94 %
Crystal growTemperature: 298 K / Method: vapor diffusion, hanging drop
Details: 0.2 M Na Citrate, 11-13% PEG 3350, 1.05% 1-butanol, 5 mM TCEP

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 19-ID / Wavelength: 0.9791 Å
DetectorType: ADSC QUANTUM 315 / Detector: CCD / Date: Mar 31, 2014
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9791 Å / Relative weight: 1
ReflectionResolution: 3.04→47.98 Å / Num. obs: 87780 / % possible obs: 96.4 % / Redundancy: 2.1 % / Rmerge(I) obs: 0.075 / Net I/σ(I): 9.5
Reflection shellResolution: 3.04→3.19 Å / Redundancy: 2.1 % / Rmerge(I) obs: 0.534 / Mean I/σ(I) obs: 2 / % possible all: 98.9

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Processing

Software
NameVersionClassification
PHENIX1.9_1692refinement
XDSJanuary 10, 2014data reduction
SCALA3.3.21data scaling
PHASER2.5.5phasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 4PO6

4po6


Resolution: 3.04→42.954 Å / SU ML: 0.47 / Cross valid method: FREE R-VALUE / σ(F): 1.35 / Phase error: 31.57 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2764 4303 4.91 %
Rwork0.2573 --
obs0.2582 87695 96.15 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Refinement stepCycle: LAST / Resolution: 3.04→42.954 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms27917 0 0 12 27929
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.01128602
X-RAY DIFFRACTIONf_angle_d1.60338611
X-RAY DIFFRACTIONf_dihedral_angle_d19.01410588
X-RAY DIFFRACTIONf_chiral_restr0.0924185
X-RAY DIFFRACTIONf_plane_restr0.0064854
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3.04-3.14860.36584590.36058483X-RAY DIFFRACTION99
3.1486-3.27470.3544550.32298521X-RAY DIFFRACTION99
3.2747-3.42360.33534630.30778478X-RAY DIFFRACTION98
3.4236-3.6040.33143750.29288521X-RAY DIFFRACTION98
3.604-3.82970.28044330.26348431X-RAY DIFFRACTION97
3.8297-4.12520.24464750.2528261X-RAY DIFFRACTION96
4.1252-4.53990.2624420.24038233X-RAY DIFFRACTION95
4.5399-5.19590.24354320.22658050X-RAY DIFFRACTION93
5.1959-6.54260.28713790.24978266X-RAY DIFFRACTION95
6.5426-42.95870.24483900.2278148X-RAY DIFFRACTION92
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.27040.27370.41492.0033-0.75544.2447-0.0551-0.28190.0207-0.17240.12420.18620.29110.1935-0.06910.10250.0125-0.0037-0.2205-0.0134-0.058.65957.903623.8522
20.7723-0.7695-1.21172.7471-1.56061.99170.10910.23520.0225-0.41640.00750.0663-0.04860.3095-0.11660.1-0.0397-0.0528-0.07190.0094-0.211212.422320.99563.1435
31.7369-1.5320.02380.7239-0.46912.3467-0.09380.0137-0.1803-0.04460.0288-0.44940.28790.28160.0650.16620.09890.0775-0.1559-0.0401-0.015422.2661-7.6857
46.01892.2837-1.5193.5084-2.07731.2970.0152-0.0929-0.24520.05220.03620.35330.1332-0.1658-0.05140.2729-0.09420.0346-0.2872-0.0959-0.0843-9.7633-13.577919.8497
53.6662-1.0360.67512.4007-0.47682.3337-0.0525-0.20340.1611-0.08050.11360.0324-0.09060.182-0.06110.1355-0.02710.0008-0.23040.0432-0.05656.987639.01824.7701
62.30851.2196-0.40673.15260.22910.82430.0573-0.1862-0.131-0.17-0.14410.3669-0.0838-0.39950.08680.0064-0.0359-0.156-0.09750.0659-0.0856-13.363525.522819.8665
72.6278-0.59090.56861.40222.71743.5298-0.0193-0.28230.3790.27040.1660.0395-0.2085-0.2649-0.14660.24130.06940.0412-0.2717-0.02390.005-5.476854.12934.5583
82.31980.9397-2.27161.0723-1.0884.54970.077-0.06290.1857-0.27280.0121-0.2412-0.24160.1754-0.08910.22380.03250.0917-0.29850.15680.12479.510960.9066.3419
94.3537-3.1023-0.1982.62810.3994-0.14040.08440.1852-0.03810.0159-0.1602-0.144-0.1080.250.0758-0.32790.1217-0.01050.2857-0.1092-0.081122.58367.5072-41.515
101.9148-2.4641.8154.9441-1.45292.68820.05580.5123-0.09620.24280.00190.09040.00880.0741-0.0577-0.3929-0.00740.080.282-0.1612-0.13451.38919.5018-45.7925
110.4199-0.9877-0.54670.08992.41570.5841-0.06330.1281-0.0266-0.15140.0273-0.01570.15540.01770.036-0.01130.1926-0.18430.0903-0.0809-0.073615.2661-9.9789-52.3888
12-0.1685-2.10082.27563.7135-2.26372.0474-0.0097-0.0673-0.1040.0933-0.04450.01240.08560.02660.0543-0.01710.1976-0.0533-0.089-0.0780.220.1538-11.6305-20.0393
131.82220.5436-1.01245.8968-0.7073.0287-0.020.32640.0433-0.2546-0.0418-0.09880.01860.13010.0618-0.10130.01360.09810.10390.052-0.22922.654539.0118-41.6071
142.2158-0.67230.30324.1636-2.54672.735-0.0118-0.0649-0.00680.0951-0.02470.14810.0930.22410.0364-0.1332-0.03050.14690.0601-0.0424-0.188417.674627.7582-20.531
15-0.86583.0450.18892.5508-1.01024.3520.0078-0.05580.2360.0427-0.0065-0.197-0.15850.0402-0.0013-0.0401-0.1010.0635-0.03230.08090.11530.36656.3818-30.8565
160.7969-1.5353.21872.0124-3.1682.6925-0.05920.04990.1868-0.0468-0.00570.1433-0.0301-0.0450.0649-0.05810.0681-0.05040.0720.18140.03762.931858.9012-48.5663
172.583-0.158-0.14321.1076-1.54415.852-0.03520.07040.00430.17270.1611-0.10860.29570.0129-0.1260.1930.0181-0.0542-0.2203-0.0044-0.1186-43.57147.8171-54.864
180.8121-0.5765-0.17832.9730.90583.22110.1169-0.3415-0.00310.23090.0466-0.07890.0257-0.4375-0.1635-0.03550.0527-0.06150.10680.0117-0.3344-47.74120.5423-33.9617
19-0.70263.09930.43540.8674-0.10912.2255-0.0361-0.0756-0.21420.0034-0.00130.32110.2317-0.26570.03740.3344-0.1770.0215-0.13060.0875-0.1028-56.8899-8.1397-47.8401
202.5449-2.7543-0.80923.61811.31070.66410.02950.0317-0.199-0.05570.0355-0.32830.07690.1786-0.0650.24970.1564-0.0429-0.21510.0221-0.082-24.7184-13.4286-50.905
213.96880.44840.83541.67880.5133.478-0.10150.00230.20420.03520.1545-0.0410.05230.1872-0.053-0.01060.014-0.0462-0.1252-0.0381-0.072-42.789239.049-55.3044
223.1721-1.4109-0.05891.93830.07580.426-0.06070.1622-0.02920.22260.0519-0.27890.05470.49920.0088-0.16880.037-0.14390.2181-0.1259-0.2276-22.157325.9292-50.6743
233.48051.5691.14690.1544-2.312.0522-0.04210.17380.3467-0.22140.1223-0.1442-0.12570.2401-0.0803-0.1443-0.1677-0.06220.06280.09010.0275-30.767154.7783-64.7394
242.5894-2.1441-1.71971.99670.68443.43970.0166-0.22780.13740.19250.05540.3299-0.2143-0.0296-0.0719-0.181-0.04150.0138-0.0858-0.17970.085-46.433860.6176-36.5497
254.66791.77191.15533.0966-1.10070.9963-0.0796-0.05310.0704-0.0824-0.00250.27170.1957-0.37790.0821-0.172-0.1685-0.07140.05510.0836-0.0167-57.60416.323310.4774
263.34142.3691.47814.34991.4443.3677-0.0501-0.30230.0043-0.1705-0.0723-0.268-0.0305-0.1540.1224-0.1736-0.04820.0653-0.12290.0648-0.0349-36.596918.500714.8621
270.37971.95650.01883.2916-2.31691.3153-0.0309-0.1321-0.13190.12020.0131-0.03530.16330.01060.01780.2199-0.2004-0.0923-0.17320.0775-0.0231-49.9561-11.10721.2081
28-1.67362.04722.01824.97772.4232.4750.00590.0897-0.0323-0.0265-0.00080.04230.0658-0.0458-0.00520.2131-0.1833-0.0797-0.10730.0511-0.0343-55.1065-12.5631-11.1388
293.2854-2.2091-2.06722.66122.0032-0.71070.0121-0.2367-0.0329-0.0005-0.19460.0449-0.0149-0.28340.1825-0.0651-0.1041-0.04750.2957-0.14-0.3617-58.266537.532411.0885
301.3413-0.21051.82913.6041.77264.2269-0.0026-0.0522-0.0174-0.12450.0076-0.25760.0536-0.4912-0.005-0.0557-0.01150.09490.10830.05-0.2585-53.109826.7741-10.2812
312.9513-3.6524-1.211901.43152.4738-0.01070.0250.0797-0.01740.00850.0936-0.0047-0.10180.0022-0.01050.1944-0.05710.1746-0.0802-0.0166-66.405655.01690.5454
321.06251.52652.80063.83672.32212.2706-0.0265-0.1140.11620.02-0.0176-0.1584-0.0769-0.03290.04410.0906-0.0507-0.0502-0.0516-0.17720.0675-38.983957.835918.217
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1{ A|37 - A|125 }A37 - 125
2X-RAY DIFFRACTION2{ A|130 - A|265 }A130 - 265
3X-RAY DIFFRACTION3{ A|266 - A|389 }A266 - 389
4X-RAY DIFFRACTION4{ A|390 - A|514 }A390 - 514
5X-RAY DIFFRACTION5{ B|37 - B|125 }B37 - 125
6X-RAY DIFFRACTION6{ B|130 - B|265 }B130 - 265
7X-RAY DIFFRACTION7{ B|266 - B|389 }B266 - 389
8X-RAY DIFFRACTION8{ B|390 - B|514 }B390 - 514
9X-RAY DIFFRACTION9{ C|37 - C|125 }C37 - 125
10X-RAY DIFFRACTION10{ C|130 - C|265 }C130 - 265
11X-RAY DIFFRACTION11{ C|266 - C|389 }C266 - 389
12X-RAY DIFFRACTION12{ C|390 - C|514 }C390 - 514
13X-RAY DIFFRACTION13{ D|37 - D|125 }D37 - 125
14X-RAY DIFFRACTION14{ D|130 - D|265 }D130 - 265
15X-RAY DIFFRACTION15{ D|266 - D|389 }D266 - 389
16X-RAY DIFFRACTION16{ D|390 - D|514 }D390 - 514
17X-RAY DIFFRACTION17{ E|37 - E|125 }E37 - 125
18X-RAY DIFFRACTION18{ E|130 - E|265 }E130 - 265
19X-RAY DIFFRACTION19{ E|266 - E|389 }E266 - 389
20X-RAY DIFFRACTION20{ E|390 - E|514 }E390 - 514
21X-RAY DIFFRACTION21{ F|37 - F|125 }F37 - 125
22X-RAY DIFFRACTION22{ F|130 - F|265 }F130 - 265
23X-RAY DIFFRACTION23{ F|266 - F|389 }F266 - 389
24X-RAY DIFFRACTION24{ F|390 - F|514 }F390 - 514
25X-RAY DIFFRACTION25{ G|37 - G|125 }G37 - 125
26X-RAY DIFFRACTION26{ G|130 - G|265 }G130 - 265
27X-RAY DIFFRACTION27{ G|266 - G|389 }G266 - 389
28X-RAY DIFFRACTION28{ G|390 - G|514 }G390 - 514
29X-RAY DIFFRACTION29{ H|37 - H|125 }H37 - 125
30X-RAY DIFFRACTION30{ H|130 - H|265 }H130 - 265
31X-RAY DIFFRACTION31{ H|266 - H|389 }H266 - 389
32X-RAY DIFFRACTION32{ H|390 - H|514 }H390 - 514

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