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Yorodumi- PDB-6o5z: Crystal Structure of the human MLKL pseudokinase domain bound to ... -
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-Basic information
Entry | Database: PDB / ID: 6o5z | ||||||||||||
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Title | Crystal Structure of the human MLKL pseudokinase domain bound to compound 2 | ||||||||||||
Components | Mixed lineage kinase domain-like protein | ||||||||||||
Keywords | transferase/transferase inhibitor / Pseudokinase / Inhibitor / Necroptosis / TRANSFERASE / transferase-transferase inhibitor complex | ||||||||||||
Function / homology | Function and homology information execution phase of necroptosis / Microbial modulation of RIPK1-mediated regulated necrosis / necroptotic signaling pathway / TRP channels / RIPK1-mediated regulated necrosis / protein homotrimerization / necroptotic process / Regulation of necroptotic cell death / cell junction / defense response to virus ...execution phase of necroptosis / Microbial modulation of RIPK1-mediated regulated necrosis / necroptotic signaling pathway / TRP channels / RIPK1-mediated regulated necrosis / protein homotrimerization / necroptotic process / Regulation of necroptotic cell death / cell junction / defense response to virus / cell surface receptor signaling pathway / protein-containing complex binding / protein kinase binding / ATP binding / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||||||||
Biological species | Homo sapiens (human) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.285 Å | ||||||||||||
Authors | Cowan, A.D. / Murphy, J.M. / Pierotti, C.L. / Lessene, G.L. / Czabotar, P.E. | ||||||||||||
Funding support | Australia, 3items
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Citation | Journal: Acs Chem.Biol. / Year: 2020 Title: Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway. Authors: Pierotti, C.L. / Tanzer, M.C. / Jacobsen, A.V. / Hildebrand, J.M. / Garnier, J.M. / Sharma, P. / Lucet, I.S. / Cowan, A.D. / Kersten, W.J.A. / Luo, M.X. / Liang, L.Y. / Fitzgibbon, C. / ...Authors: Pierotti, C.L. / Tanzer, M.C. / Jacobsen, A.V. / Hildebrand, J.M. / Garnier, J.M. / Sharma, P. / Lucet, I.S. / Cowan, A.D. / Kersten, W.J.A. / Luo, M.X. / Liang, L.Y. / Fitzgibbon, C. / Garnish, S.E. / Hempel, A. / Nachbur, U. / Huang, D.C.S. / Czabotar, P.E. / Silke, J. / van Delft, M.F. / Murphy, J.M. / Lessene, G. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6o5z.cif.gz | 236.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6o5z.ent.gz | 190.3 KB | Display | PDB format |
PDBx/mmJSON format | 6o5z.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6o5z_validation.pdf.gz | 350.8 KB | Display | wwPDB validaton report |
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Full document | 6o5z_full_validation.pdf.gz | 353.5 KB | Display | |
Data in XML | 6o5z_validation.xml.gz | 2.2 KB | Display | |
Data in CIF | 6o5z_validation.cif.gz | 8.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/o5/6o5z ftp://data.pdbj.org/pub/pdb/validation_reports/o5/6o5z | HTTPS FTP |
-Related structure data
Related structure data | 4mwiS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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1 |
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2 |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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