Entry Database : PDB / ID : 4xyc Structure visualization Downloads & linksTitle NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES ComponentsGlutamine synthetase 1 Details Keywords LIGASE/LIGASE INHIBITOR / LIGASE / ATP BINDING / LIGASE-LIGASE INHIBITOR COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
glutamine synthetase / glutamine biosynthetic process / glutamine synthetase activity / : / ATP binding / metal ion binding / cytoplasm Similarity search - Function Glutamine synthetase class-I, adenylation site / Glutamine synthetase class-I adenylation site. / Glutamine synthetase, N-terminal domain / Glutamine synthetase type I / Glutamine synthetase/guanido kinase, catalytic domain / Glutamine synthetase, N-terminal conserved site / Glutamine synthetase signature 1. / Glutamine synthetase, beta-Grasp domain / Creatine Kinase; Chain A, domain 2 / Glutamine synthetase, glycine-rich site ... Glutamine synthetase class-I, adenylation site / Glutamine synthetase class-I adenylation site. / Glutamine synthetase, N-terminal domain / Glutamine synthetase type I / Glutamine synthetase/guanido kinase, catalytic domain / Glutamine synthetase, N-terminal conserved site / Glutamine synthetase signature 1. / Glutamine synthetase, beta-Grasp domain / Creatine Kinase; Chain A, domain 2 / Glutamine synthetase, glycine-rich site / Glutamine synthetase putative ATP-binding region signature. / Glutamine synthetase, N-terminal domain / Glutamine synthetase, N-terminal domain superfamily / Glutamine synthetase, catalytic domain / Glutamine synthetase, catalytic domain / Glutamine synthetase, catalytic domain / Glutamine synthetase/guanido kinase, catalytic domain / Ubiquitin-like (UB roll) / Roll / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Mycobacterium tuberculosis (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.3 Å DetailsAuthors Couturier, C. / Silve, S. / Morales, R. / Ppessegue, B. / Llopart, S. / Nair, A. / Bauer, A. / Scheiper, B. / poeverlein, c. / Ganzhorn, A. ...Couturier, C. / Silve, S. / Morales, R. / Ppessegue, B. / Llopart, S. / Nair, A. / Bauer, A. / Scheiper, B. / poeverlein, c. / Ganzhorn, A. / Lagrange, S. / Bacque, E. CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2015Title : Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies.Authors : Couturier, C. / Silve, S. / Morales, R. / Pessegue, B. / Llopart, S. / Nair, A. / Bauer, A. / Scheiper, B. / Poverlein, C. / Ganzhorn, A. / Lagrange, S. / Bacque, E. History Deposition Feb 2, 2015 Deposition site : RCSB / Processing site : PDBERevision 1.0 Mar 25, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Apr 1, 2015 Group : Database referencesRevision 1.2 Jan 10, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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