- PDB-4xnw: The human P2Y1 receptor in complex with MRS2500 -
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基本情報
登録情報
データベース: PDB / ID: 4xnw
タイトル
The human P2Y1 receptor in complex with MRS2500
要素
P2Y purinoceptor 1,Rubredoxin,P2Y purinoceptor 1
キーワード
TRANSPORT PROTEIN / human P2Y1 receptor / G protein coupled receptor / platelet activation / membrane protein / PSI-Biology / Structural Genomics / GPCR Network / GPCR
機能・相同性
機能・相同性情報
G protein-coupled ATP receptor activity / relaxation of muscle / G protein-coupled ADP receptor activity / P2Y receptors / cellular response to purine-containing compound / G protein-coupled purinergic nucleotide receptor activity / positive regulation of inositol trisphosphate biosynthetic process / positive regulation of monoatomic ion transport / positive regulation of penile erection / negative regulation of norepinephrine secretion ...G protein-coupled ATP receptor activity / relaxation of muscle / G protein-coupled ADP receptor activity / P2Y receptors / cellular response to purine-containing compound / G protein-coupled purinergic nucleotide receptor activity / positive regulation of inositol trisphosphate biosynthetic process / positive regulation of monoatomic ion transport / positive regulation of penile erection / negative regulation of norepinephrine secretion / A1 adenosine receptor binding / glial cell migration / alkane catabolic process / regulation of presynaptic cytosolic calcium ion concentration / G protein-coupled adenosine receptor signaling pathway / positive regulation of hormone secretion / signal transduction involved in regulation of gene expression / response to growth factor / cellular response to ATP / eating behavior / regulation of synaptic vesicle exocytosis / monoatomic ion transport / presynaptic active zone membrane / response to mechanical stimulus / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / blood vessel diameter maintenance / establishment of localization in cell / protein localization to plasma membrane / platelet activation / ADP binding / cilium / ADP signalling through P2Y purinoceptor 1 / phospholipase C-activating G protein-coupled receptor signaling pathway / signaling receptor activity / regulation of cell shape / cell body / positive regulation of cytosolic calcium ion concentration / scaffold protein binding / G alpha (q) signalling events / basolateral plasma membrane / postsynaptic membrane / electron transfer activity / postsynaptic density / cell surface receptor signaling pathway / positive regulation of ERK1 and ERK2 cascade / iron ion binding / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / apical plasma membrane / protein heterodimerization activity / glutamatergic synapse / dendrite / cell surface / positive regulation of transcription by RNA polymerase II / ATP binding / plasma membrane 類似検索 - 分子機能
プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長
波長: 1 Å / 相対比: 1
反射
解像度: 2.7→50 Å / Num. obs: 20471 / % possible obs: 98.2 % / 冗長度: 4.9 % / Net I/σ(I): 18.9
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解析
ソフトウェア
名称
バージョン
分類
REFMAC
5.7.0029
精密化
HKL-2000
データ削減
SCALEPACK
データスケーリング
PHASER
位相決定
精密化
解像度: 2.7→29.31 Å / Cor.coef. Fo:Fc: 0.924 / Cor.coef. Fo:Fc free: 0.896 / SU B: 8.27 / SU ML: 0.184 / 交差検証法: THROUGHOUT / ESU R Free: 0.085 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.26714
1027
5.1 %
RANDOM
Rwork
0.21834
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obs
0.22094
19283
98.1 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK