TRANSPORT PROTEIN/INHIBITOR / human P2Y1 receptor / G protein coupled receptor / platelet activation / membrane protein / inhibitor complex / TRANSPORT PROTEIN-INHIBITOR complex / PSI-Biology / Structural Genomics / GPCR Network / GPCR
Function / homology
Function and homology information
G protein-coupled ATP receptor activity / relaxation of muscle / G protein-coupled ADP receptor activity / P2Y receptors / cellular response to purine-containing compound / G protein-coupled purinergic nucleotide receptor activity / positive regulation of inositol trisphosphate biosynthetic process / positive regulation of monoatomic ion transport / positive regulation of penile erection / negative regulation of norepinephrine secretion ...G protein-coupled ATP receptor activity / relaxation of muscle / G protein-coupled ADP receptor activity / P2Y receptors / cellular response to purine-containing compound / G protein-coupled purinergic nucleotide receptor activity / positive regulation of inositol trisphosphate biosynthetic process / positive regulation of monoatomic ion transport / positive regulation of penile erection / negative regulation of norepinephrine secretion / A1 adenosine receptor binding / glial cell migration / alkane catabolic process / regulation of presynaptic cytosolic calcium ion concentration / G protein-coupled adenosine receptor signaling pathway / positive regulation of hormone secretion / signal transduction involved in regulation of gene expression / response to growth factor / cellular response to ATP / eating behavior / regulation of synaptic vesicle exocytosis / monoatomic ion transport / presynaptic active zone membrane / response to mechanical stimulus / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / blood vessel diameter maintenance / establishment of localization in cell / protein localization to plasma membrane / platelet activation / ADP binding / cilium / ADP signalling through P2Y purinoceptor 1 / phospholipase C-activating G protein-coupled receptor signaling pathway / signaling receptor activity / regulation of cell shape / cell body / positive regulation of cytosolic calcium ion concentration / scaffold protein binding / G alpha (q) signalling events / basolateral plasma membrane / postsynaptic membrane / electron transfer activity / postsynaptic density / cell surface receptor signaling pathway / positive regulation of ERK1 and ERK2 cascade / iron ion binding / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / apical plasma membrane / protein heterodimerization activity / glutamatergic synapse / dendrite / cell surface / positive regulation of transcription by RNA polymerase II / ATP binding / plasma membrane Similarity search - Function
Mass: 47468.289 Da / Num. of mol.: 1 / Mutation: D320N Source method: isolated from a genetically manipulated source Details: Chimera protein of P2Y purinoceptor 1 (P2RY1_HUMA) with Rubredoxin (RUBR_CLOPA) inserted into ICL3 domain between residues 247LYS and 253PRO, and replaced residues 248ASN to 252SER. Source: (gene. exp.) Homo sapiens (human), (gene. exp.) Clostridium pasteurianum (bacteria) Gene: P2RY1 / Production host: Spodoptera (butterflies/moths) / References: UniProt: P47900, UniProt: P00268
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