登録情報 | データベース: PDB / ID: 4wno |
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タイトル | Structure of ULK1 bound to an inhibitor |
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要素 | Serine/threonine-protein kinase ULK1 |
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キーワード | TRANSFERASE/TRANSFERASE Inhibitor / kinase / autophagy / inhibitor / TRANSFERASE-TRANSFERASE Inhibitor complex |
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機能・相同性 | 機能・相同性情報
omegasome membrane / neuron projection regeneration / regulation of protein lipidation / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / positive regulation of autophagosome assembly / phagophore assembly site membrane / piecemeal microautophagy of the nucleus / RAB GEFs exchange GTP for GDP on RABs / regulation of tumor necrosis factor-mediated signaling pathway ...omegasome membrane / neuron projection regeneration / regulation of protein lipidation / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / positive regulation of autophagosome assembly / phagophore assembly site membrane / piecemeal microautophagy of the nucleus / RAB GEFs exchange GTP for GDP on RABs / regulation of tumor necrosis factor-mediated signaling pathway / axon extension / phagophore assembly site / TBC/RABGAPs / reticulophagy / Macroautophagy / Receptor Mediated Mitophagy / response to starvation / autophagosome membrane / autophagosome assembly / autophagosome / cellular response to nutrient levels / regulation of macroautophagy / negative regulation of protein-containing complex assembly / positive regulation of autophagy / macroautophagy / Regulation of TNFR1 signaling / peptidyl-threonine phosphorylation / recycling endosome / small GTPase binding / autophagy / protein localization / neuron projection development / GTPase binding / peptidyl-serine phosphorylation / mitochondrial outer membrane / protein autophosphorylation / non-specific serine/threonine protein kinase / negative regulation of cell population proliferation / axon / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / endoplasmic reticulum membrane / protein-containing complex binding / signal transduction / ATP binding / identical protein binding / cytoplasm / cytosol類似検索 - 分子機能 Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Serine/threonine-protein kinase Atg1-like, tMIT domain / Atg1-like, MIT domain 1 / Serine/threonine-protein kinase Atg1-like / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ...Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Serine/threonine-protein kinase Atg1-like, tMIT domain / Atg1-like, MIT domain 1 / Serine/threonine-protein kinase Atg1-like / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-3RF / Serine/threonine-protein kinase ULK1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.56 Å |
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データ登録者 | Lazarus, M.B. / Novotny, C.J. / Shokat, K.M. |
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引用 | ジャーナル: Acs Chem.Biol. / 年: 2015 タイトル: Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors. 著者: Lazarus, M.B. / Novotny, C.J. / Shokat, K.M. |
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履歴 | 登録 | 2014年10月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年1月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年1月28日 | Group: Database references |
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改定 1.2 | 2017年11月22日 | Group: Derived calculations / Other ...Derived calculations / Other / Refinement description / Source and taxonomy カテゴリ: entity_src_gen / pdbx_database_status ...entity_src_gen / pdbx_database_status / pdbx_struct_oper_list / software Item: _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible ..._entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation / _software.classification |
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改定 1.3 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / refine_hist Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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