Entry Database : PDB / ID : 4urx Structure visualization Downloads & linksTitle The crystal structure of H-Ras and SOS in complex with ligands ComponentsGTPASE HRAS HRAS SON OF SEVENLESS HOMOLOG 1 DetailsKeywords SIGNALING PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
midbrain morphogenesis / regulation of pro-B cell differentiation / vitellogenesis / pericardium morphogenesis / cardiac atrium morphogenesis / heart trabecula morphogenesis / regulation of T cell differentiation in thymus / GTPase complex / Signaling by FGFR3 in disease / positive regulation of small GTPase mediated signal transduction ... midbrain morphogenesis / regulation of pro-B cell differentiation / vitellogenesis / pericardium morphogenesis / cardiac atrium morphogenesis / heart trabecula morphogenesis / regulation of T cell differentiation in thymus / GTPase complex / Signaling by FGFR3 in disease / positive regulation of small GTPase mediated signal transduction / positive regulation of epidermal growth factor receptor signaling pathway / Activation of RAC1 / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / Interleukin-15 signaling / positive regulation of ruffle assembly / blood vessel morphogenesis / regulation of MAP kinase activity / positive regulation of miRNA metabolic process / NRAGE signals death through JNK / regulation of T cell proliferation / T-helper 1 type immune response / positive regulation of wound healing / Regulation of KIT signaling / negative regulation of GTPase activity / roof of mouth development / defense response to protozoan / eyelid development in camera-type eye / RAS GTPase cycle mutants / Activation of RAS in B cells / leukocyte migration / Signaling by FGFR3 fusions in cancer / RAS signaling downstream of NF1 loss-of-function variants / neurotrophin TRK receptor signaling pathway / positive regulation of actin cytoskeleton reorganization / B cell homeostasis / Fc-epsilon receptor signaling pathway / SOS-mediated signalling / RET signaling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / GRB2:SOS provides linkage to MAPK signaling for Integrins / hair follicle development / positive regulation of protein targeting to membrane / SHC1 events in ERBB4 signaling / Signaling by FGFR3 point mutants in cancer / Signalling to RAS / fibroblast growth factor receptor signaling pathway / SHC-related events triggered by IGF1R / Activated NTRK2 signals through FRS2 and FRS3 / adipose tissue development / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / Estrogen-stimulated signaling through PRKCZ / Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants / Signaling by PDGFRA extracellular domain mutants / Interleukin receptor SHC signaling / Signaling by FGFR4 in disease / Role of LAT2/NTAL/LAB on calcium mobilization / SHC-mediated cascade:FGFR3 / Signal attenuation / MET activates RAS signaling / positive regulation of phospholipase C activity / SHC-mediated cascade:FGFR2 / Signaling by FLT3 ITD and TKD mutants / Erythropoietin activates RAS / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR3 signaling / Tie2 Signaling / FRS-mediated FGFR2 signaling / G protein activity / FRS-mediated FGFR4 signaling / EPHB-mediated forward signaling / FRS-mediated FGFR1 signaling / Signaling by FGFR2 in disease / GRB2 events in EGFR signaling / Ras activation upon Ca2+ influx through NMDA receptor / RAC1 GTPase cycle / Signaling by FLT3 fusion proteins / SHC1 events in EGFR signaling / p38MAPK events / FLT3 Signaling / small monomeric GTPase / EGFR Transactivation by Gastrin / intrinsic apoptotic signaling pathway / Signaling by FGFR1 in disease / GRB2 events in ERBB2 signaling / GTPase activator activity / CD209 (DC-SIGN) signaling / Downstream signal transduction / SHC1 events in ERBB2 signaling / NCAM signaling for neurite out-growth / guanyl-nucleotide exchange factor activity / FCERI mediated Ca+2 mobilization / Insulin receptor signalling cascade / Constitutive Signaling by Overexpressed ERBB2 / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / VEGFR2 mediated cell proliferation / G alpha (12/13) signalling events / positive regulation of epithelial cell proliferation Similarity search - Function Son of sevenless (SoS) protein; Chain S, domain 1 / Son of sevenless (SoS) protein Chain: S domain 1 / Son of Sevenless (SoS) protein; Chain S, domain 2 / Ras guanine-nucleotide exchange factors catalytic domain / Ras guanine-nucleotide exchange factor, conserved site / Ras Guanine-nucleotide exchange factors domain signature. / RasGEF N-terminal motif / Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif / Ras guanine-nucleotide exchange factors N-terminal domain profile. / Ras-like guanine nucleotide exchange factor, N-terminal ... Son of sevenless (SoS) protein; Chain S, domain 1 / Son of sevenless (SoS) protein Chain: S domain 1 / Son of Sevenless (SoS) protein; Chain S, domain 2 / Ras guanine-nucleotide exchange factors catalytic domain / Ras guanine-nucleotide exchange factor, conserved site / Ras Guanine-nucleotide exchange factors domain signature. / RasGEF N-terminal motif / Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif / Ras guanine-nucleotide exchange factors N-terminal domain profile. / Ras-like guanine nucleotide exchange factor, N-terminal / Ras-like guanine nucleotide exchange factor / Ras guanine-nucleotide exchange factor, catalytic domain superfamily / RasGEF domain / Ras guanine nucleotide exchange factor domain superfamily / Ras guanine-nucleotide exchange factors catalytic domain profile. / Guanine nucleotide exchange factor for Ras-like small GTPases / Ras guanine-nucleotide exchange factors catalytic domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / RhoGEF domain / Dbl homology (DH) domain superfamily / Dbl homology (DH) domain profile. / Dbl homology (DH) domain / Small GTPase, Ras-type / small GTPase Ras family profile. / PH domain / PH domain profile. / Rho (Ras homology) subfamily of Ras-like small GTPases / Pleckstrin homology domain. / Pleckstrin homology domain / Small GTPase / Ras family / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 / Histone-fold / Small GTP-binding protein domain / PH-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / Up-down Bundle / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.49 Å DetailsAuthors Winter, J.J.G. / Anderson, M. / Blades, K. / Brassington, C. / Breeze, A.L. / Chresta, C. / Embrey, K. / Fairley, G. / Faulder, P. / Finlay, M.R.V. ...Winter, J.J.G. / Anderson, M. / Blades, K. / Brassington, C. / Breeze, A.L. / Chresta, C. / Embrey, K. / Fairley, G. / Faulder, P. / Finlay, M.R.V. / Kettle, J.G. / Nowak, T. / Overman, R. / Patel, S.J. / Perkins, P. / Spadola, L. / Tart, J. / Tucker, J. / Wrigley, G. CitationJournal : J.Med.Chem. / Year : 2015Title : Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.Authors: Winter, J. / Anderson, M. / Blades, K. / Chresta, C. / Embrey, K.J. / Fairley, G. / Faulder, P. / Finlay, M.R.V. / Kettle, J.G. / Nowak, T. / Overman, R. / Patel, S.J. / Perkins, P. / ... Authors : Winter, J. / Anderson, M. / Blades, K. / Chresta, C. / Embrey, K.J. / Fairley, G. / Faulder, P. / Finlay, M.R.V. / Kettle, J.G. / Nowak, T. / Overman, R. / Patel, S.J. / Perkins, P. / Spadola, L. / Tart, J. / Tucker, J.A. / Wrigley, G. History Deposition Jul 2, 2014 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 4, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Mar 25, 2015 Group : Database references
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