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- PDB-4tgf: SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DER... -

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Basic information

Entry
Database: PDB / ID: 4tgf
TitleSOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DERIVED FROM 1*H NMR DATA
ComponentsDES-VAL-1,VAL-2,TRANSFORMING GROWTH FACTOR, ALPHA
KeywordsGROWTH FACTOR
Function / homology
Function and homology information


hepatocyte proliferation / transmembrane receptor protein tyrosine kinase activator activity / Cargo concentration in the ER / COPII-mediated vesicle transport / epidermal growth factor receptor binding / Inhibition of Signaling by Overexpressed EGFR / EGFR interacts with phospholipase C-gamma / ERBB2-EGFR signaling pathway / Signaling by EGFR / positive regulation of cell division ...hepatocyte proliferation / transmembrane receptor protein tyrosine kinase activator activity / Cargo concentration in the ER / COPII-mediated vesicle transport / epidermal growth factor receptor binding / Inhibition of Signaling by Overexpressed EGFR / EGFR interacts with phospholipase C-gamma / ERBB2-EGFR signaling pathway / Signaling by EGFR / positive regulation of cell division / mammary gland alveolus development / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / GAB1 signalosome / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of mitotic nuclear division / positive regulation of epithelial cell proliferation / growth factor activity / EGFR downregulation / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / epidermal growth factor receptor signaling pathway / Constitutive Signaling by Aberrant PI3K in Cancer / Cargo recognition for clathrin-mediated endocytosis / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / cytoplasmic vesicle / angiogenesis / basolateral plasma membrane / Estrogen-dependent gene expression / cell surface receptor signaling pathway / Extra-nuclear estrogen signaling / positive regulation of MAPK cascade / intracellular signal transduction / receptor ligand activity / positive regulation of cell population proliferation / endoplasmic reticulum membrane / perinuclear region of cytoplasm / cell surface / extracellular space / extracellular region / plasma membrane
Similarity search - Function
Laminin / Laminin / EGF-like domain profile. / EGF-like domain signature 1. / EGF-like domain signature 2. / EGF-like domain / Ribbon / Mainly Beta
Similarity search - Domain/homology
Protransforming growth factor alpha
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsKline, T.P. / Brown, F.K. / Brown, S.C. / Jeffs, P.W. / Kopple, K.D. / Mueller, L.
Citation
Journal: Biochemistry / Year: 1990
Title: Solution structures of human transforming growth factor alpha derived from 1H NMR data.
Authors: Kline, T.P. / Brown, F.K. / Brown, S.C. / Jeffs, P.W. / Kopple, K.D. / Mueller, L.
#1: Journal: Biochemistry / Year: 1989
Title: 1H NMR Assignment and Secondary Structural Elements of Human Transforming Growth Factor Alpha
Authors: Brown, S.C. / Mueller, L. / Jeffs, P.W.
History
DepositionJun 13, 1990Processing site: BNL
Revision 1.0Oct 15, 1991Provider: repository / Type: Initial release
Revision 1.1Mar 25, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf
Item: _pdbx_database_status.process_site
Revision 1.4Nov 20, 2024Group: Data collection / Database references / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: DES-VAL-1,VAL-2,TRANSFORMING GROWTH FACTOR, ALPHA


Theoretical massNumber of molelcules
Total (without water)5,5601
Polymers5,5601
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)4 / -
Representative

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Components

#1: Protein/peptide DES-VAL-1,VAL-2,TRANSFORMING GROWTH FACTOR, ALPHA


Mass: 5560.246 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P01135
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Processing

NMR software
NameDeveloperClassification
DSPACEHARE RESEARCH, INC.refinement
X-PLORBRUNGERrefinement
NMR ensembleConformers submitted total number: 4

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