登録情報 | データベース: PDB / ID: 4rh9 |
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タイトル | Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide |
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要素 | - Epidermal growth factor receptor substrate 15
- Tyrosine-protein phosphatase non-receptor type 3
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キーワード | HYDROLASE/PROTEIN BINDING / Alpha Beta / HYDROLASE-PROTEIN BINDING complex |
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機能・相同性 | 機能・相同性情報
regulation of membrane depolarization during action potential / negative regulation of membrane protein ectodomain proteolysis / Golgi to endosome transport / regulation of sodium ion transmembrane transporter activity / clathrin coat of coated pit / vesicle organization / postsynaptic neurotransmitter receptor internalization / clathrin coat assembly / endocytic recycling / aggresome ...regulation of membrane depolarization during action potential / negative regulation of membrane protein ectodomain proteolysis / Golgi to endosome transport / regulation of sodium ion transmembrane transporter activity / clathrin coat of coated pit / vesicle organization / postsynaptic neurotransmitter receptor internalization / clathrin coat assembly / endocytic recycling / aggresome / endosomal transport / positive regulation of receptor recycling / negative regulation of epidermal growth factor receptor signaling pathway / negative regulation of mitotic cell cycle / sodium channel regulator activity / polyubiquitin modification-dependent protein binding / clathrin-coated pit / cytoskeletal protein binding / phosphotyrosine residue binding / protein dephosphorylation / protein-tyrosine-phosphatase / basal plasma membrane / InlB-mediated entry of Listeria monocytogenes into host cell / protein tyrosine phosphatase activity / liver regeneration / EGFR downregulation / Negative regulation of MET activity / cytoplasmic side of plasma membrane / SH3 domain binding / endocytosis / Negative regulation of MAPK pathway / MAPK cascade / protein transport / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / regulation of cell population proliferation / early endosome membrane / ATPase binding / postsynapse / receptor-mediated endocytosis of virus by host cell / cytoskeleton / cadherin binding / symbiont entry into host cell / apical plasma membrane / intracellular membrane-bounded organelle / glutamatergic synapse / calcium ion binding / membrane / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Protein-tyrosine phosphatase, non-receptor type-3, -4 / PTPN3/4, FERM domain C-lobe / Cytoskeletal-regulatory complex EF hand / EH domain profile. / Eps15 homology domain / EH domain / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal ...Protein-tyrosine phosphatase, non-receptor type-3, -4 / PTPN3/4, FERM domain C-lobe / Cytoskeletal-regulatory complex EF hand / EH domain profile. / Eps15 homology domain / EH domain / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal / FERM N-terminal domain / FERM domain signature 1. / FERM conserved site / Ubiquitin-interacting motif. / FERM domain signature 2. / Ubiquitin interacting motif / Ubiquitin-interacting motif (UIM) domain profile. / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / Protein tyrosine phosphatase superfamily / FERM superfamily, second domain / Protein-Tyrosine Phosphatase; Chain A / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / PH-like domain superfamily / Ubiquitin-like domain superfamily / Alpha-Beta Complex / Alpha Beta類似検索 - ドメイン・相同性 Tyrosine-protein phosphatase non-receptor type 3 / Epidermal growth factor receptor substrate 15類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.598 Å |
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データ登録者 | Chen, K.-E. / Meng, T.C. / Wang, A.H.-J. |
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引用 | ジャーナル: Structure / 年: 2015 タイトル: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. 著者: Chen, K.E. / Li, M.Y. / Chou, C.C. / Ho, M.R. / Chen, G.C. / Meng, T.C. / Wang, A.H. |
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履歴 | 登録 | 2014年10月1日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2015年3月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年7月18日 | Group: Advisory / Data collection / Database references カテゴリ: citation / diffrn_source / pdbx_unobs_or_zero_occ_atoms Item: _citation.journal_id_ISSN / _citation.journal_volume ..._citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _diffrn_source.pdbx_synchrotron_beamline / _diffrn_source.type |
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改定 1.2 | 2023年11月8日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / struct_conn / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
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改定 1.3 | 2023年12月6日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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