Entry Database : PDB / ID : 5h08 Structure visualization Downloads & linksTitle Human PTPRZ D1 domain complexed with NAZ2329 ComponentsReceptor-type tyrosine-protein phosphatase zeta Details Keywords HYDROLASE/HYDROLASE INHIBITOR / Protein Tyrosine Phosphatase / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
perineuronal net / regulation of oligodendrocyte progenitor proliferation / MDK and PTN in ALK signaling / transmembrane receptor protein tyrosine phosphatase activity / regulation of myelination / Other interleukin signaling / positive regulation of oligodendrocyte differentiation / oligodendrocyte differentiation / peptidyl-tyrosine dephosphorylation / hematopoietic progenitor cell differentiation ... perineuronal net / regulation of oligodendrocyte progenitor proliferation / MDK and PTN in ALK signaling / transmembrane receptor protein tyrosine phosphatase activity / regulation of myelination / Other interleukin signaling / positive regulation of oligodendrocyte differentiation / oligodendrocyte differentiation / peptidyl-tyrosine dephosphorylation / hematopoietic progenitor cell differentiation / protein dephosphorylation / protein-tyrosine-phosphatase / axonogenesis / protein tyrosine phosphatase activity / central nervous system development / integrin binding / negative regulation of neuron apoptotic process / learning or memory / synapse / extracellular region / plasma membrane Similarity search - Function Receptor-type tyrosine-protein phosphatase, carbonic anhydrase domain / Protein tyrosine phosphatase superfamily / Protein-Tyrosine Phosphatase; Chain A / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. ... Receptor-type tyrosine-protein phosphatase, carbonic anhydrase domain / Protein tyrosine phosphatase superfamily / Protein-Tyrosine Phosphatase; Chain A / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / Fibronectin type III domain / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin-like fold / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.53 Å DetailsAuthors Sugawara, H. Funding support Japan, 1items Details Hide detailsOrganization Grant number Country Japan Agency for Medical Research and development 15im0110409b0104 Japan
CitationJournal : Sci Rep / Year : 2017Title : Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells
Authors :
Fujikawa, A. / Sugawara, H. / Tanaka, T. / Matsumoto, M. / Kuboyama, K. / Suzuki, R. / Tanga, N. / Ogata, A. / Masumura, M. / Noda, M. Show more 1 items Show less#1: Journal : Scientific Reports / Year : 2016Title : Small-molecule inhibition of PTPRZ suppresses tumor growth in a rat model of glioblastoma.
Authors :
Fujikawa, A. / Nagahira, A. / Sugawara, H. / Ishii, K. / Imajo, S. / Matsumoto, M. / Kuboyama, K. / Suzuki, R. / Tanga, N. / Noda, M. / Uchiyama, S. / Tomoo, T. / Ogata, A. / Masumura, M. / Noda, M. History Deposition Oct 4, 2016 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jul 26, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Aug 16, 2017 Group : Database references / Category : citationItem : _citation.journal_abbrev / _citation.journal_volume ... _citation.journal_abbrev / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed Revision 1.2 Nov 8, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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