Entry Database : PDB / ID : 4qnh Structure visualization Downloads & linksTitle Calcium-calmodulin (T79D) complexed with the calmodulin binding domain from a small conductance potassium channel SK2-a ComponentsCalmodulin Small conductance calcium-activated potassium channel protein 2 DetailsKeywords ion transport/protein binding / ion channel / ion transport-protein binding complexFunction / homology Function and homology informationFunction Domain/homology Component
Cam-PDE 1 activation / eNOS activation / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / RHO GTPases activate IQGAPs / Glycogen breakdown (glycogenolysis) / : / CaMK IV-mediated phosphorylation of CREB / Calcineurin activates NFAT / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde ... Cam-PDE 1 activation / eNOS activation / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / RHO GTPases activate IQGAPs / Glycogen breakdown (glycogenolysis) / : / CaMK IV-mediated phosphorylation of CREB / Calcineurin activates NFAT / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / CLEC7A (Dectin-1) induces NFAT activation / VEGFR2 mediated vascular permeability / RHO GTPases activate PAKs / Activation of RAC1 downstream of NMDARs / Protein methylation / : / Stimuli-sensing channels / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / Calmodulin induced events / Ca2+ activated K+ channels / Smooth Muscle Contraction / FCERI mediated Ca+2 mobilization / small conductance calcium-activated potassium channel activity / Platelet degranulation / RAF activation / Synthesis of IP3 and IP4 in the cytosol / PKA activation / regulation of store-operated calcium channel activity / Ion transport by P-type ATPases / Phase 0 - rapid depolarisation / membrane repolarization during atrial cardiac muscle cell action potential / regulation of high voltage-gated calcium channel activity / Inactivation, recovery and regulation of the phototransduction cascade / Extra-nuclear estrogen signaling / calcium-activated potassium channel activity / : / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / : / establishment of protein localization to mitochondrial membrane / positive regulation of potassium ion transport / type 3 metabotropic glutamate receptor binding / Activation of Ca-permeable Kainate Receptor / inward rectifier potassium channel activity / alpha-actinin binding / Ca2+ pathway / regulation of potassium ion transmembrane transport / establishment of protein localization to membrane / RAF/MAP kinase cascade / regulation of synaptic vesicle endocytosis / negative regulation of high voltage-gated calcium channel activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / regulation of synaptic vesicle exocytosis / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / regulation of cardiac muscle cell action potential / Ion homeostasis / positive regulation of DNA binding / positive regulation of ryanodine-sensitive calcium-release channel activity / nitric-oxide synthase binding / negative regulation of ryanodine-sensitive calcium-release channel activity / protein phosphatase activator activity / regulation of neuronal synaptic plasticity / : / adenylate cyclase binding / catalytic complex / detection of calcium ion / regulation of cardiac muscle contraction / calcium channel regulator activity / regulation of ryanodine-sensitive calcium-release channel activity / smooth endoplasmic reticulum / Unblocking of NMDA receptors, glutamate binding and activation / calcium channel inhibitor activity / phosphatidylinositol 3-kinase binding / enzyme regulator activity / activation of adenylate cyclase activity / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / : / titin binding / regulation of calcium-mediated signaling / voltage-gated potassium channel complex / potassium ion transmembrane transport / calcium channel complex / T-tubule / response to amphetamine / adenylate cyclase activator activity / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / potassium ion transport / regulation of cytokinesis / positive regulation of nitric-oxide synthase activity / spindle microtubule / calcium-mediated signaling / response to calcium ion / modulation of chemical synaptic transmission / sarcolemma Similarity search - Function Calmodulin / Calmodulin-binding domain / Potassium channel, calcium-activated, SK / SK, calmodulin-binding domain superfamily / Calmodulin binding domain / Calcium-activated SK potassium channel / Calmodulin binding domain / Helix Hairpins - #70 / Potassium channel domain / Ion channel ... Calmodulin / Calmodulin-binding domain / Potassium channel, calcium-activated, SK / SK, calmodulin-binding domain superfamily / Calmodulin binding domain / Calcium-activated SK potassium channel / Calmodulin binding domain / Helix Hairpins - #70 / Potassium channel domain / Ion channel / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Helix Hairpins / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.02 Å DetailsAuthors Zhang, M. / Pascal, J.M. / Logothetis, D.E. / Zhang, J.F. CitationJournal : Nat.Chem.Biol. / Year : 2014Title : Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.Authors : Zhang, M. / Meng, X.Y. / Cui, M. / Pascal, J.M. / Logothetis, D.E. / Zhang, J.F. History Deposition Jun 17, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 6, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Sep 3, 2014 Group : Database referencesRevision 1.2 Feb 28, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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