- PDB-4pm0: PDE7A catalytic domain in complex with 2-(Cyclopentylamino)thieno... -
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ID or keywords:
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Basic information
Entry
Database: PDB / ID: 4pm0
Title
PDE7A catalytic domain in complex with 2-(Cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivative
Components
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Keywords
HYDROLASE / phosphodiesterase / PDE7
Function / homology
Function and homology information
3',5'-cyclic-AMP phosphodiesterase / cAMP catabolic process / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP-mediated signaling / G alpha (s) signalling events / perinuclear region of cytoplasm / nucleus / metal ion binding / cytosol Similarity search - Function
Resolution: 2.1→29.75 Å / Cor.coef. Fo:Fc: 0.962 / Cor.coef. Fo:Fc free: 0.938 / SU B: 4.041 / SU ML: 0.105 / Cross valid method: THROUGHOUT / ESU R: 0.167 / ESU R Free: 0.158 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.21763
1417
5.2 %
RANDOM
Rwork
0.1721
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obs
0.17443
25982
92.8 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: MASK